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1.发明授权Modified Bordetella adenylate cyclase comprising or lacking CD11b/CD18 interaction domain and uses thereof 有权包含或缺少CD11b / CD18相互作用结构域的修饰的Bordetella腺苷酸环化酶及其用途公开(公告)号：US07906123B1
公开(公告)日：2011-03-15
申请号：US11713708
申请日：2007-03-05
申请人： Claude Leclerc , Mohammed El-Azami El-Idrissi , Daniel Ladant , Cécile Bauche , Peter Sebo , Jirina Loucka , Radim Osicka
发明人： Claude Leclerc , Mohammed El-Azami El-Idrissi , Daniel Ladant , Cécile Bauche , Peter Sebo , Jirina Loucka , Radim Osicka
CPC分类号： C12N9/88 , A61K39/00 , A61K2039/53 , C12Y406/01001
摘要： The invention relates to modified Bordetella adenylate cyclase toxins which are deficient for CD11b/CD18 binding and to their use in the preparation of pharmaceutical composition for the treatment of whooping cough and/or for the protection against Bordetella infection. The invention also relates to specific fragments of Bordetella adenylate cyclase comprising the CD11b/CD18 interaction domain and their use, especially for targeting a molecule of interest to CD11b expressing cells.
摘要翻译： 本发明涉及对于CD11b / CD18结合缺陷的修饰的博德氏菌属腺苷酸环化酶毒素，以及它们在制备用于治疗百日咳和/或防止博德氏菌感染的药物组合物中的用途。 本发明还涉及包含CD11b / CD18相互作用结构域的博德氏菌属腺苷酸环化酶的特异性片段及其用途，特别是用于将感兴趣的分子靶向CD11b表达细胞。
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2.发明申请Modified bordetella adenylate cyclase comprising or lacking CD11b/CD18 interaction domain and uses thereof 审中-公开包含或缺少CD11b / CD18相互作用结构域的修饰的腺苷酸环化酶及其用途公开(公告)号：US20060159697A1
公开(公告)日：2006-07-20
申请号：US11304590
申请日：2005-12-16
申请人： Claude Leclerc , Mohammed El-Idrissi , Daniel Ladant , Cecile Bauche , Peter Sebo , Jirina Loucka , Radim Osicka
发明人： Claude Leclerc , Mohammed El-Idrissi , Daniel Ladant , Cecile Bauche , Peter Sebo , Jirina Loucka , Radim Osicka
CPC分类号： C12N9/88 , A61K39/00 , A61K2039/53 , C12Y406/01001
摘要： The invention relates to modified Bordetella adenylate cyclase toxins which are deficient for CD11b/CD18 binding and to their use in the preparation of pharmaceutical composition for the treatment of whooping cough and/or for the protection against Bordetella infection. The invention also relates to specific fragments of Bordetella adenylate cyclase comprising the CD11b/CD18 interaction domain and their use, especially for targeting a molecule of interest to CD11b expressing cells.
摘要翻译： 本发明涉及对于CD11b / CD18结合缺陷的修饰的博德氏菌属腺苷酸环化酶毒素，以及它们在制备用于治疗百日咳和/或防止博德氏菌感染的药物组合物中的用途。 本发明还涉及包含CD11b / CD18相互作用结构域的博德氏菌属腺苷酸环化酶的特异性片段及其用途，特别是用于将感兴趣的分子靶向CD11b表达细胞。
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3.发明申请Recombinant adenylate cyclase of BORDETELLA SP. for diagnostic and immunomonitoring uses, method of diagnosing or immunomonitoring using said recombinant adenylate cyclase, and kit for diagnosing or immunomonitoring comprising said recombinant adenylate cyclase 审中-公开BORDETELLA SP的重组腺苷酸环化酶。 用于诊断和免疫监测用途，使用所述重组腺苷酸环化酶进行诊断或免疫监测的方法，以及用于诊断或免疫监测的试剂盒，其包含所述重组腺苷酸环化酶公开(公告)号：US20090317854A1
公开(公告)日：2009-12-24
申请号：US12289896
申请日：2008-11-06
申请人： Claude Leclerc , Laleh Majlessi , Geraldine Louf , Peter Sebo , Marcela Simsova , Martin Vordermeier , Robert Wilkinson , Elisabeth Scholvinck , Jirina Loucka
发明人： Claude Leclerc , Laleh Majlessi , Geraldine Louf , Peter Sebo , Marcela Simsova , Martin Vordermeier , Robert Wilkinson , Elisabeth Scholvinck , Jirina Loucka
IPC分类号： C12Q1/02
CPC分类号： G01N33/505
摘要： Diagnostic testing and immunomonitoring that uses genetically detoxified Bordetella pertussis CyaA as a delivery system are effective in tracking any immune responses, such as those generated by infectious and non-infectious diseases, or vaccinations, for example. T cells previously stimulated by a given antigen can be restimulated in vitro by the same antigen fused or chemically coupled to CyaA or a fragment thereof. The invention includes diagnostic tests and immunomonitoring for tuberculosis by providing a delivery system, which can deliver the M. tuberculosis immunodominant proteins ESAT-6 and CFP-10, to human cells and non-human animal cells, such as cattle. In addition, fusion proteins between CyaA and cancer antigens are also provided as diagnostic tests and immunomonitoring systems for cancers, such as melanoma.
摘要翻译： 使用遗传性解毒的百日咳博来氏菌CyaA作为分娩系统的诊断测试和免疫监测有助于跟踪任何免疫应答，例如由感染性和非感染性疾病产生的免疫应答，或接种疫苗。 先前由给定抗原刺激的T细胞可以通过与CyaA或其片段融合或化学偶联的相同抗原体外再刺激。 本发明通过提供可将结核分枝杆菌免疫显性蛋白质ESAT-6和CFP-10递送给人类细胞和非人动物细胞如牛的递送系统，包括对结核病的诊断测试和免疫监测。 此外，还提供CyaA和癌抗原之间的融合蛋白作为癌症如黑色素瘤的诊断试验和免疫监测系统。
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4.发明申请Recombinant adenylate cyclase of Bordetella sp. for diagnostic and immunomonitoring uses, method of diagnosing or immunomonitoring using said recombinant adenylate cyclase, and kit for diagnosing or immunomonitoring comprising said recombinant adenylate cyclase 审中-公开博德特氏菌重组腺苷酸环化酶 用于诊断和免疫监测用途，使用所述重组腺苷酸环化酶进行诊断或免疫监测的方法，以及用于诊断或免疫监测的试剂盒，其包含所述重组腺苷酸环化酶公开(公告)号：US20060019323A1
公开(公告)日：2006-01-26
申请号：US10994191
申请日：2004-11-22
申请人： Claude Leclerc , Laleh Majlessi , Geraldine Schlecht-Louf , Peter Sebo , Marcela Simsova , Martin Vordermeier , Robert Wilkinson , Elisabeth Scholvinck , Jirina Loucka
发明人： Claude Leclerc , Laleh Majlessi , Geraldine Schlecht-Louf , Peter Sebo , Marcela Simsova , Martin Vordermeier , Robert Wilkinson , Elisabeth Scholvinck , Jirina Loucka
IPC分类号： G01N33/554 , G01N33/569
CPC分类号： G01N33/5695 , C12Q1/527 , G01N33/505 , G01N33/6893 , G01N2333/235 , G01N2333/988
摘要： Diagnostic testing and immunomonitoring that uses genetically detoxified Bordetella pertussis CyaA as a delivery system are effective in tracking any immune responses, such as those generated by infectious and non-infectious diseases, or vaccinations, for example. T cells previously stimulated by a given antigen can be restimulated in vitro by the same antigen fused or chemically coupled to CyaA or a fragment thereof. The invention includes diagnostic tests and immunomonitoring for tuberculosis by providing a delivery system, which can deliver the M. tuberculosis immunodominant proteins ESAT-6 and CFP-10, to human cells and non-human animal cells, such as cattle. In addition, fusion proteins between CyaA and cancer antigens are also provided as diagnostic tests and immunomonitoring systems for cancers, such as melanoma.
摘要翻译： 使用遗传性解毒的百日咳博来氏菌CyaA作为分娩系统的诊断测试和免疫监测有助于跟踪任何免疫应答，例如由感染性和非感染性疾病产生的免疫应答，或接种疫苗。 先前由给定抗原刺激的T细胞可以通过与CyaA或其片段融合或化学偶联的相同抗原体外再刺激。 本发明通过提供可将结核分枝杆菌免疫显性蛋白质ESAT-6和CFP-10递送给人类细胞和非人动物细胞如牛的递送系统，包括对结核病的诊断测试和免疫监测。 此外，还提供CyaA和癌抗原之间的融合蛋白作为癌症如黑色素瘤的诊断试验和免疫监测系统。
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公开(公告)号：US20060286613A1
公开(公告)日：2006-12-21
申请号：US11434892
申请日：2006-05-17
申请人： Claude Leclerc , Laleh Majlessi , Geraldine Louf , Peter Sebo , Marcela Simsova , Martin Vordermeier , Robert Wilkinson , Elisabeth Scholvinck , Jirina Loucka
发明人： Claude Leclerc , Laleh Majlessi , Geraldine Louf , Peter Sebo , Marcela Simsova , Martin Vordermeier , Robert Wilkinson , Elisabeth Scholvinck , Jirina Loucka
IPC分类号： G01N33/554 , G01N33/569
CPC分类号： G01N33/505
摘要： Diagnostic testing and immunomonitoring that uses genetically detoxified Bordetella pertussis CyaA as a delivery system are effective in tracking any immune responses, such as those generated by infectious and non-infectious diseases, or vaccinations, for example. T cells previously stimulated by a given antigen can be restimulated in vitro by the same antigen fused or chemically coupled to CyaA or a fragment thereof. The invention includes diagnostic tests and immunomonitoring for tuberculosis by providing a delivery system, which can deliver the M. tuberculosis immunodominant proteins ESAT-6 and CFP-10, to human cells and non-human animal cells, such as cattle. In addition, fusion proteins between CyaA and cancer antigens are also provided as diagnostic tests and immunomonitoring systems for cancers, such as melanoma.
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