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    Steroids esterified in position 17 and thioesterified in position 21, a process for preparing them and their use as medicaments
    4.
    发明授权
    Steroids esterified in position 17 and thioesterified in position 21, a process for preparing them and their use as medicaments 失效
    甾族酯在17位酯化并在21位硫酯化，其制备方法及其用作药物

    公开(公告)号：US4427671A

    公开(公告)日：1984-01-24

    申请号：US397715

    申请日：1982-07-13

    申请人： Dieran R. Torossian ,  Gilbert G. Aubard ,  Claude P. Roux ,  Agnes G. Grouhel

    发明人： Dieran R. Torossian ,  Gilbert G. Aubard ,  Claude P. Roux ,  Agnes G. Grouhel

    IPC分类号： A61K31/57 ,  A61P11/00 ,  A61P17/00 ,  A61P29/00 ,  A61P37/08 ,  C07J31/00 ,  A61K31/56 ,  C07J7/00

    CPC分类号： C07J31/006 ,  Y10S514/826

    摘要： Compounds of formula: ##STR1## wherein A and B each represent, independently of each other, a straight-chained or branched alkyl group having from 1 to 6 carbon atoms or a phenyl group optionally mono- or polysubstituted by alkyl radicals having from 1 to 6 carbon atoms, alkoxy groups having from 1 to 6 carbon atoms or halogen, T and U, independently of each other, represent hydrogen atoms or together form a double bond, V is a hydrogen atom or a methyl group at the .alpha.-position, W is a hydrogen atom or a halogen atom at the .alpha.-position, X is a hydroxy group at the .beta.-position and Y is a hydrogen atom or X and Y may together represent an oxygen atom, and Z.sub.1 is a hydrogen atom, a methyl group at the .alpha.- or .beta.-position, while Z.sub.2 is a hydrogen atom, or Z.sub.1 and Z.sub.2 together form a methylene group. These compounds have anti-inflammatory activity.

    摘要翻译： 其中A和B各自独立地表示具有1至6个碳原子的直链或支链烷基或任选被1至6个碳原子的烷基单取代或多取代的苯基， 6个碳原子，具有1至6个碳原子的烷氧基或卤素，T和U彼此独立地表示氢原子或一起形成双键，V是氢原子或α-位上的甲基， W是α位上的氢原子或卤素原子，X是β位上的羟基，Y是氢原子，X和Y可以一起代表氧原子，Z1是氢原子， 甲基在α或β-位，而Z 2是氢原子，或Z 1和Z 2一起形成亚甲基。 这些化合物具有抗炎活性。