公开(公告)号：US20180092897A1

公开(公告)日：2018-04-05

申请号：US15830727

申请日：2017-12-04

Applicant: CLEARSIDE BIOMEDICAL, INC.

Inventor： Vladimir Zarnitsyn ,  Samirkumar Patel ,  Daniel White ,  Glenn Noronha ,  Brian Burke

IPC: A61K31/4439 ,  C07K16/22 ,  A61K47/26 ,  A61K9/00 ,  A61K9/10 ,  A61K9/16 ,  A61M37/00 ,  A61K47/38 ,  A61K47/12 ,  A61K45/06 ,  A61K31/573 ,  A61K39/00

CPC classification number: A61K31/4439 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/10 ,  A61K9/16 ,  A61K31/573 ,  A61K45/06 ,  A61K47/12 ,  A61K47/26 ,  A61K47/38 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2300/00 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0061 ,  C07K16/22

Abstract: Methods and devices are provided for targeted non-surgical administration of a drug formulation to the suprachoroidal space (SCS) of the eye of a human subject for the treatment of a posterior ocular disorder or a choroidal malady. In one embodiment, the method comprises inserting a hollow microneedle into the eye at an insertion site and infusing a drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. In one embodiment, the fluid drug formulation comprises drug nanoparticles or microparticles.

公开(公告)号：US09931330B2

公开(公告)日：2018-04-03

申请号：US15673073

申请日：2017-08-09

Applicant: CLEARSIDE BIOMEDICAL, INC.

Inventor： Vladimir Zarnitsyn ,  Samirkumar Patel ,  Daniel White ,  Glenn Noronha ,  Brian Burke

IPC: A61K31/4439 ,  A61K47/26 ,  A61K45/06 ,  A61K9/00 ,  A61K47/38 ,  A61K9/16 ,  A61K31/573 ,  A61K47/12 ,  A61K9/10 ,  A61K39/00 ,  A61M37/00 ,  C07K16/22

CPC classification number: A61K31/4439 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/10 ,  A61K9/16 ,  A61K31/573 ,  A61K45/06 ,  A61K47/12 ,  A61K47/26 ,  A61K47/38 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2300/00 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0061 ,  C07K16/22

Abstract: Methods and devices are provided for targeted non-surgical administration of a drug formulation to the suprachoroidal space (SCS) of the eye of a human subject for the treatment of a posterior ocular disorder or a choroidal malady. In one embodiment, the method comprises inserting a hollow microneedle into the eye at an insertion site and infusing a drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. In one embodiment, the fluid drug formulation comprises drug nanoparticles or microparticles.

公开(公告)号：US09636332B2

公开(公告)日：2017-05-02

申请号：US15001610

申请日：2016-01-20

Applicant: Clearside Biomedical, Inc.

Inventor： Vladimir Zarnitsyn ,  Samirkumar Patel ,  Daniel White ,  Glenn Noronha ,  Brian Burke

IPC: A61K31/4439 ,  A61K47/12 ,  A61K47/26 ,  A61K9/16 ,  A61K45/06 ,  A61K31/573 ,  A61K9/10 ,  A61K9/00 ,  A61K47/38 ,  A61K39/00 ,  A61M37/00 ,  C07K16/22

CPC classification number: A61K31/4439 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/10 ,  A61K9/16 ,  A61K31/573 ,  A61K45/06 ,  A61K47/12 ,  A61K47/26 ,  A61K47/38 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2300/00 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0061 ,  C07K16/22

Abstract: Methods and devices are provided for targeted non-surgical administration of a drug formulation to the suprachoroidal space (SCS) of the eye of a human subject for the treatment of a posterior ocular disorder or a choroidal malady. In one embodiment, the method comprises inserting a hollow microneedle into the eye at an insertion site and infusing a drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. In one embodiment, the fluid drug formulation comprises drug nanoparticles or microparticles.

公开(公告)号：US20150258120A1

公开(公告)日：2015-09-17

申请号：US14441151

申请日：2013-11-08

Applicant: CLEARSIDE BIOMEDICAL, INC.

Inventor： Vladimir Zarnitsyn ,  Samirkumar Patel ,  Daniel White ,  Glenn Noronha ,  Brian Burke

IPC: A61K31/573 ,  A61K9/00 ,  A61M37/00 ,  A61K9/16

CPC classification number: A61K31/4439 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/10 ,  A61K9/16 ,  A61K31/573 ,  A61K45/06 ,  A61K47/12 ,  A61K47/26 ,  A61K47/38 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2300/00 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0061 ,  C07K16/22

Abstract: Methods and devices are provided for targeted non-surgical administration of a drug formulation to the suprachoroidal space (SCS) of the eye of a human subject for the treatment of a posterior ocular disorder or a choroidal malady. In one embodiment, the method comprises inserting a hollow microneedle into the eye at an insertion site and infusing a drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. In one embodiment, the fluid drug formulation comprises drug nanoparticles or microparticles.

Abstract translation: 提供了用于将药物制剂靶向非手术施用于人受试者眼睛的脉络膜上空间（SCS）以治疗后眼部疾病或脉络膜性疾病的方法和装置。 在一个实施例中，该方法包括在插入部位将中空微针插入眼睛，并将药物制剂通过插入的微针并进入眼睛的脉络膜上空间，其中输注的药物制剂在远离插入物的脉管外空间内流动 输液过程中的位置。 在一个实施方案中，流体药物制剂包含药物纳米颗粒或微粒。

公开(公告)号：US11596545B2

公开(公告)日：2023-03-07

申请号：US16178162

申请日：2018-11-01

Applicant: CLEARSIDE BIOMEDICAL, INC.

Inventor： Rafael Victor Andino ,  Thomas Edward Godfrey ,  Shelley Eckert Hancock ,  Samirkumar Patel ,  Keleigh Jo Mahn ,  Jesse Yoo ,  Vladimir Zarnitsyn

IPC: A61F9/00 ,  A61K9/00 ,  A61N1/04 ,  A61N1/30 ,  A61N1/32 ,  A61F9/007 ,  A61K9/10

Abstract: Devices, methods, and kits for ocular drug delivery are described herein. An apparatus can include a housing, an energy storage member, a barrel, and a hub. The housing contains the energy storage member. A proximal end portion of the barrel is coupled to a distal end portion of the housing. The barrel is configured to contain medicament and includes at least a portion of a piston and an elastomeric member. The piston is configured to move the elastomeric member within the barrel in response to a force produced by the energy storage member. The hub is coupled to a distal end portion of the barrel. An inner surface of the hub defines a nozzle through which the medicament flows when the elastomeric member moves within the barrel. The nozzle and the energy storage member are collectively configured to produce a fluid jet to access a target location within an eye.

公开(公告)号：US09572800B2

公开(公告)日：2017-02-21

申请号：US15086485

申请日：2016-03-31

Applicant: Clearside Biomedical, Inc.

Inventor： Vladimir Zarnitsyn ,  Samirkumar Patel ,  Daniel White ,  Glenn Noronha ,  Brian Burke ,  Jennifer Kissner

IPC: A61K9/00 ,  A61K9/10 ,  A61K9/16 ,  A61K31/573 ,  A61K31/4439 ,  A61K39/00 ,  A61K45/06 ,  A61K47/12 ,  A61K47/26 ,  A61K47/38 ,  A61M37/00 ,  C07K16/22

CPC classification number: A61K31/4439 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/10 ,  A61K9/16 ,  A61K31/573 ,  A61K45/06 ,  A61K47/12 ,  A61K47/26 ,  A61K47/38 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2300/00 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0061 ,  C07K16/22

Abstract: Methods and devices are provided for targeted non-surgical administration of a drug formulation to the suprachoroidal space (SCS) of the eye of a human subject for the treatment of a posterior ocular disorder or a choroidal malady. In one embodiment, the method comprises inserting a hollow microneedle into the eye at an insertion site and infusing a drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. In one embodiment, the fluid drug formulation comprises drug nanoparticles or microparticles.

Abstract translation: 提供了用于将药物制剂靶向非手术施用于人受试者眼睛的脉络膜上空间（SCS）以治疗后眼部疾病或脉络膜性疾病的方法和装置。 在一个实施例中，该方法包括在插入部位将中空微针插入眼睛，并将药物制剂通过插入的微针并进入眼睛的脉络膜上空间，其中输注的药物制剂在远离插入物的脉管外空间内流动 输液过程中的位置。 在一个实施方案中，流体药物制剂包含药物纳米颗粒或微粒。