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公开(公告)号：US06399137B1
公开(公告)日：2002-06-04
申请号：US09625667
申请日：2000-07-26
IPC分类号： A23D9007
摘要： The present invention provides a stable foodstuffs which contain a cholesterol lowering amount of a sterol or stanol ester, crystal fat inhibitors and emulsifiers. The foodstuffs, including salad dressings are stable even when refrigerated.
摘要翻译： 本发明提供了含有降胆固醇量的甾醇或甾烷醇酯，结晶脂肪抑制剂和乳化剂的稳定的食品。 食品，包括沙拉酱，即使在冷藏时也是稳定的。
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公开(公告)号：US06123978A
公开(公告)日：2000-09-26
申请号：US143817
申请日：1998-08-31
摘要： The present invention provides a stable foodstuffs which contain a cholesterol lowering amount of a sterol or stanol ester, crystal fat inhibitors and emulsifiers. The foodstuffs, including salad dressings are stable even when refrigerated.
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公开(公告)号：US06054144A
公开(公告)日：2000-04-25
申请号：US185788
申请日：1998-11-04
IPC分类号： A61K9/14 , A61K9/16 , A61K31/575 , A61K9/20
CPC分类号： A61K31/575 , A61K9/145 , A61K9/146 , A61K9/1617 , A61K9/1629 , A61K9/1652
摘要： A method for preparing .beta.-sitosterol, oryzanol, esters of both of these compounds and related compounds are disclosed which provides the sterol in a readily consumable form. The method includes the spray drying of the .beta.-sitosterol in a mixed micelle formulation. The product is provided in a convenient form that can be provided to food or drinks or incorporated into solid and suspension dosage forms.
摘要翻译： 公开了制备β-谷甾醇，谷维素，这两种化合物的酯和相关化合物的方法，其提供了易于消耗的形式的甾醇。 该方法包括在混合胶束制剂中喷雾干燥β-谷甾醇。 产品以方便的形式提供，可以提供给食品或饮料或并入固体和悬浮剂形式。
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公开(公告)号：US06242001B1
公开(公告)日：2001-06-05
申请号：US09200623
申请日：1998-11-30
IPC分类号： A61K914
CPC分类号： A61K9/145 , A61K31/575 , Y10S514/951
摘要： A method for preparing sterol/stanol and sterol/stanol ester compositions with improved dispersibility is provided by co-melting the sterol/stanol and/or sterol/stanol ester with highly branched hydrocarbons and then grinding the resulting product. A method for preparing the compounds is also disclosed. The ground compound is suitable for formulating into orally administered products suitable for control of blood serum cholesterol.
摘要翻译： 通过将甾醇/甾烷醇和/或甾醇/甾烷醇酯与高度支化的烃共熔，然后研磨所得产物，提供了具有改进的分散性的固醇/甾烷醇和甾醇/甾烷醇酯组合物的制备方法。 还公开了一种制备该化合物的方法。 地面化合物适用于配制成适合于控制血清胆固醇的口服制剂。
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公开(公告)号：US6110502A
公开(公告)日：2000-08-29
申请号：US25952
申请日：1998-02-19
申请人： Brid Burruano , Richard D. Bruce , Michael R. Hoy
发明人： Brid Burruano , Richard D. Bruce , Michael R. Hoy
CPC分类号： A61K31/575 , A61K9/145 , A61K9/146 , A61K9/1617 , A61K9/1629 , A61K9/1652
摘要： A method for preparing .beta.-sitosterol is disclosed which provides the sterol in a readily consumable form. The method includes the spray drying of the .beta.-sitosterol in a mixed micelle formulation. The product is provided in a convenient form that can be provided to food or drinks or incorporated into solid and suspension dosage forms.
摘要翻译： 公开了一种制备β-谷甾醇的方法，其以易于消耗的形式提供固醇。 该方法包括在混合胶束制剂中喷雾干燥β-谷甾醇。 产品以方便的形式提供，可以提供给食品或饮料或并入固体和悬浮剂形式。
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公开(公告)号：US06387411B2
公开(公告)日：2002-05-14
申请号：US09826072
申请日：2001-04-04
IPC分类号： A61K914
CPC分类号： A61K9/145 , A61K31/575 , Y10S514/951
摘要： A method for preparing sterol/stanol and sterol/stanol ester compositions with improved dispersibility is provided by co-melting the sterol/stanol and/or sterol/stanol ester with highly branched hydrocarbons and then grinding the resulting product. A method for preparing the compounds is also disclosed. The ground compound is suitable for formulating into orally administered products suitable for control of blood serum cholesterol.
摘要翻译： 通过将甾醇/甾烷醇和/或甾醇/甾烷醇酯与高度支化的烃共熔，然后研磨所得产物，提供了具有改进的分散性的固醇/甾烷醇和甾醇/甾烷醇酯组合物的制备方法。 还公开了一种制备该化合物的方法。 地面化合物适用于配制成适合于控制血清胆固醇的口服制剂。
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7.发明授权
公开(公告)号：US5405617A
公开(公告)日：1995-04-11
申请号：US790613
申请日：1991-11-07
IPC分类号： A61K9/16
CPC分类号： A61K9/1617
摘要： A physicochemically stable pharmaceutical matrix composition is provided comprising: a pharmaceutical active and a water insoluble aliphatic or fatty acid ester, preferably stearyl stearate; a taste mask carrier for pharmaceutical actives comprising a taste masking effective amount of an aliphatic or fatty acid ester; and a method for preparing a pharmaceutical matrix without the use of organic and/or volatile solvents comprising the steps of: melting an aliphatic or fatty acid ester; admixing at least one pharmaceutical active with the molten aliphatic or fatty acid ester; and solidifying the admixture to produce a pharmaceutical matrix composition. The matrix is composed of an aliphatic, or fatty acid, ester that has a low melting point (50.degree.-100.degree. C.) and the melt exhibits: low viscosity, recongeals rapidly when cooled, does not exhibit polymorphism, and has good mold release properties.
摘要翻译： 提供了一种物理化学稳定的药物基质组合物，其包含：药物活性物质和水不溶性脂肪酸或脂肪酸酯，优选硬脂酸硬脂酯; 用于药物活性物质的掩味载体，其包含掩味有效量的脂族或脂肪酸酯; 以及不使用有机和/或挥发性溶剂制备药物基质的方法，包括以下步骤：使脂族或脂肪酸酯熔融; 将至少一种药物活性物质与熔融的脂族或脂肪酸酯混合; 并固化该混合物以产生药物基质组合物。 该基质由具有低熔点（50℃-100℃）的脂肪酸或脂肪酸酯组成，熔体表现出：粘度低，冷却时快速组合，不显示多晶型，并具有良好的模具 释放属性。
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公开(公告)号：US06376481B2
公开(公告)日：2002-04-23
申请号：US09145528
申请日：1998-09-02
IPC分类号： A61K3156
CPC分类号： A61K9/143 , A61K9/0056 , A61K9/2095 , A61K31/575 , Y10S514/951 , Y10S514/975
摘要： The present invention provides a sterol, stanol or their corresponding acid ester in a form suitable for the manufacture of an oral dosage form. A method for producing the oral dosage form is also provided.
摘要翻译： 本发明提供了一种适于制造口服剂型的甾醇，甾烷醇或其相应的酸酯。 还提供了口服剂型的制备方法。
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