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公开(公告)号:US20130231373A1
公开(公告)日:2013-09-05
申请号:US13818779
申请日:2010-08-27
申请人: Clinton Alan Brooks , Christine Hiu-Tung Chen , Young Shin Cho , Lei Jiang , Gang Liu , Michael David Schultz
发明人: Clinton Alan Brooks , Christine Hiu-Tung Chen , Young Shin Cho , Lei Jiang , Gang Liu , Michael David Schultz
IPC分类号: C07D413/06 , C07D403/06 , C07D401/14
CPC分类号: C07D413/06 , A61K31/4015 , A61K31/4025 , A61K31/4155 , A61K31/416 , A61K31/4192 , A61K31/4245 , A61K31/4427 , A61K31/4439 , C07D207/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D407/14
摘要: The present teachings relate to compounds of Formula (I): and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R1, R2, R3, R4, R5, ring A, and Z are as defined herein. The present teachings also provide methods of preparing compounds of Formula (I) and methods of use compounds of Formula (I) in treating pathologic conditions or disorders mediated wholly or in part by deacetylases.
摘要翻译: 本发明涉及式(I)的化合物及其药学上可接受的盐,水合物,酯和前药,其中R 1,R 2,R 3,R 4,R 5,环A和Z如本文所定义。 本教导还提供制备式(I)化合物的方法和使用式(I)化合物治疗全部或部分由脱乙酰酶介导的病理状况或病症的方法。