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公开(公告)号:US20100297112A1
公开(公告)日:2010-11-25
申请号:US12064633
申请日:2006-08-25
申请人: Colin Green , Lloyd Kelland , Gail Rowlinson-Bruza
发明人: Colin Green , Lloyd Kelland , Gail Rowlinson-Bruza
IPC分类号: A61K39/395 , A61P35/00 , A61K31/352
CPC分类号: A61K31/337 , A61K31/352 , A61K39/395 , A61K2300/00
摘要: The present invention relates to combinations of compounds such as compounds of the xanthenone acetic acid class such as 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and vascular endothelial growth factor binders, in particular the monoclonal antibody Avastin™ (bevacizumab). More particularly, the invention is concerned with the use of such combinations in the treatment of cancer and pharmaceutical formulations containing such combinations.
摘要翻译: 本发明涉及化合物如呫吨酮乙酸类化合物如5,6-二甲基呫吨酮-4-乙酸(DMXAA)和血管内皮生长因子结合剂,特别是单克隆抗体Avastin TM(贝伐珠单抗))的组合。 更具体地说,本发明涉及这样的组合在治疗癌症中的用途以及含有这种组合的药物制剂。