公开(公告)号：US09514272B2

公开(公告)日：2016-12-06

申请号：US13649966

申请日：2012-10-11

Applicant: Complete Genomics, Inc.

Inventor： Bahram Ghaffarzadeh Kermani ,  Radoje Drmanac ,  Oleg Alferov

IPC: G01N33/50 ,  G06F19/22

CPC classification number: G06F19/22

Abstract: Various short reads can be grouped and identified as coming from a same long DNA fragment (e.g., by using wells with a relatively low-concentration of DNA). A histogram of the genomic coverage of a group of short reads can provide the edges of the corresponding long fragment (pulse). The knowledge of these pulses can provide an ability to determine the haploid genome and to identify structural variations.

Abstract translation: 可以将各种短读数分组并鉴定为来自相同的长DNA片段（例如，通过使用具有相对低浓度DNA的孔）。 一组短读取的基因组覆盖的直方图可以提供对应的长片段（脉冲）的边缘。 这些脉冲的知识可以提供确定单倍体基因组并鉴定结构变化的能力。

公开(公告)号：US20130096841A1

公开(公告)日：2013-04-18

申请号：US13649966

申请日：2012-10-11

Applicant: Complete Genomics, Inc.

Inventor： Bahram Ghaffarzadeh Kermani ,  Radoje Drmanac ,  Oleg Alferov

IPC: G06F17/18

CPC classification number: G06F19/22

Abstract: Various short reads can be grouped and identified as coming from a same long DNA fragment (e.g., by using wells with a relatively low-concentration of DNA). A histogram of the genomic coverage of a group of short reads can provide the edges of the corresponding long fragment (pulse). The knowledge of these pulses can provide an ability to determine the haploid genome and to identify structural variations.

Abstract translation: 可以将各种短读数分组并鉴定为来自相同的长DNA片段（例如，通过使用具有相对低浓度的DNA的孔）。 一组短读取的基因组覆盖的直方图可以提供对应的长片段（脉冲）的边缘。 这些脉冲的知识可以提供确定单倍体基因组并鉴定结构变化的能力。