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公开(公告)号：US5705489A
公开(公告)日：1998-01-06
申请号：US690449
申请日：1996-08-05
IPC分类号： C07H7/033 , A61K20060101 , A61K31/70 , A61K31/7012 , A61K47/48 , A61P7/02 , A61P43/00 , C07H20060101 , C07H3/06 , C07H7/04 , C07H11/00 , C07H13/00 , C07H15/04 , C07H15/08 , C07H15/18 , C07H15/22 , C07H15/26 , C07K9/00 , C08B37/00 , C08B37/10 , C07H15/00
摘要： The invention relates to a tuneable bisconjugate comprising two saccharides and a spacer, each saccharide being the same or different and comprising two to six monosaccharide units, at least one unit being uronic acid, characterized in that at least one of the saccharides per se has anti-thrombotic activity, and that the spacer connects at least one saccharide to the other through its non-reducing end, the chain length of the spacer being 20-120 atoms.
摘要翻译： 本发明涉及包含两种糖类和间隔物的可调式双缀合物，每种糖相同或不同，并且包含两至六个单糖单元，至少一个单元是糖醛酸，其特征在于，至少一种糖本身具有抗 并且间隔物通过其非还原性末端将至少一个糖连接到另一个，间隔物的链长为20-120个原子。
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公开(公告)号：US5872110A
公开(公告)日：1999-02-16
申请号：US876107
申请日：1997-04-30
IPC分类号： C07H15/04 , A61K31/70 , A61K31/702 , A61K31/7032 , A61K31/715 , A61P7/00 , A61P31/04 , A61P35/00 , C07D407/14 , C07H20060101 , C07H3/06 , C07H5/04 , C07H5/10 , C07H15/08 , C08B37/00 , A61K31/725 , C08B37/10
CPC分类号： C07H3/06 , Y10S514/822
摘要： The invention relates to carbohydrate derivatives having the formula I, ##STR1## wherein R.sup.1 is H or CH.sub.2 OSO.sub.3.sup.-, R.sup.2 and R.sup.3 are independently H, (1-6C)alkyl or SO.sub.3.sup.- ; R.sup.4 is OSO.sub.3.sup.- or NHSO.sub.3.sup.- ; n is 0 or 1; p is 1 or 2; or a pharmaceutically acceptable salt thereof The compounds of the invention have antithrombotic activity and may be used for inhibiting smooth muscle cell proliferation.
摘要翻译： 本发明涉及具有式I的碳水化合物衍生物，其中R 1是H或CH 2 OSO 3 - ，R 2和R 3独立地是H，（1-6C）烷基或SO 3 - ; R4是OSO3-或NHSO3-; n为0或1; p为1或2; 或其药学上可接受的盐本发明的化合物具有抗血栓形成活性，可用于抑制平滑肌细胞增殖。
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