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公开(公告)号：US20220017502A1
公开(公告)日：2022-01-20
申请号：US17311526
申请日：2019-12-06
发明人： Anna Gardberg , Victor S. Gehling , Avinash Khanna , Julian R. Levell , Jonathan E. Wilson , Kennedy Taveras
IPC分类号： C07D413/12 , C07D413/14 , A61P35/00
摘要： Provided are compounds of Formula (I): and pharmaceutically acceptable salts and compositions thereof, which are useful for treating a variety of conditions associated with TREX1.
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公开(公告)号：US20210206776A1
公开(公告)日：2021-07-08
申请号：US17057225
申请日：2019-05-17
发明人： Alexandre Côté , Avinash Khanna , Ludivine Moine
IPC分类号： C07D491/056 , A61P35/00
摘要： Provided are novel compounds of Formula (I): Formula (I); and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with methyl modifying enzymes. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with methyl modifying enzymes.
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公开(公告)号：US20240262814A1
公开(公告)日：2024-08-08
申请号：US18289467
申请日：2022-05-04
IPC分类号： C07D413/12 , A61K31/513
CPC分类号： C07D413/12 , A61K31/513
摘要： Provided are compounds of Formula (I): and pharmaceutically acceptable salts and compositions thereof, which are useful for treating a variety of conditions associated with TREX1.
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公开(公告)号：US20220313701A1
公开(公告)日：2022-10-06
申请号：US17607940
申请日：2020-05-01
IPC分类号： A61K31/5377 , A61P35/00
摘要： Provided are compounds of Formula (I): and pharmaceutically acceptable salts and compostions thereof, which are useful for treating a variety of conditions associated with TREX1.
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公开(公告)号：US20190322651A1
公开(公告)日：2019-10-24
申请号：US16387851
申请日：2019-04-18
IPC分类号： C07D405/14 , C07D405/12 , A61P35/00
摘要： Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with methyl modifying enzymes. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with methyl modifying enzymes.
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公开(公告)号：US20220289728A1
公开(公告)日：2022-09-15
申请号：US17628946
申请日：2020-07-22
发明人： Avinash Khanna , Jonathan E. Wilson
IPC分类号： C07D413/12 , C07D413/14 , C07D417/14
摘要： Provided are compounds of Formula (I): and pharmaceutically acceptable salts and compositions thereof, which are useful for treating a variety of conditions associated with TREX1.
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公开(公告)号：US11274095B2
公开(公告)日：2022-03-15
申请号：US16856454
申请日：2020-04-23
IPC分类号： C07D405/14 , C07D405/12 , A61P35/00
摘要： Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with methyl modifying enzymes. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with methyl modifying enzymes.
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公开(公告)号：US11013718B2
公开(公告)日：2021-05-25
申请号：US16671559
申请日：2019-11-01
IPC分类号： C07D205/12 , A61K31/397 , A61P31/22 , A61P31/18 , A61P35/02 , A61K31/438 , C07D221/20 , A61P35/00
摘要： Provided are novel compounds of Formula (I or Ia′): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with LSD1. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I or Ia′), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with LSD1.
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公开(公告)号：US20200317651A1
公开(公告)日：2020-10-08
申请号：US16856454
申请日：2020-04-23
IPC分类号： C07D405/14 , A61P35/00 , C07D405/12
摘要： Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with methyl modifying enzymes. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with methyl modifying enzymes.
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公开(公告)号：US20240246946A1
公开(公告)日：2024-07-25
申请号：US18288455
申请日：2022-04-25
发明人： Julian R. Levell , Aaron Coffin , Mary-Margaret Zablocki , Jonathan E. Wilson , Avinash Khanna , David J. Guerin , William T. McElroy , Jennifer L. Rocnik
IPC分类号： C07D413/14 , A61K31/513
CPC分类号： C07D413/14 , A61K31/513
摘要： Provided are compounds of Formula (I): and pharmaceutically acceptable salts and compositions thereof, which are useful for treating a variety of conditions associated with TREX1.
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