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公开(公告)号:US09745305B2
公开(公告)日:2017-08-29
申请号:US14769471
申请日:2014-03-12
发明人: Brian K. Albrecht , James Edmund Audia , Andrew Cook , Alexandre Côté , Les A. Dakin , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC分类号: C07D487/04
CPC分类号: C07D487/04
摘要: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
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公开(公告)号:US20210206776A1
公开(公告)日:2021-07-08
申请号:US17057225
申请日:2019-05-17
发明人: Alexandre Côté , Avinash Khanna , Ludivine Moine
IPC分类号: C07D491/056 , A61P35/00
摘要: Provided are novel compounds of Formula (I): Formula (I); and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with methyl modifying enzymes. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with methyl modifying enzymes.
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公开(公告)号:US20190322651A1
公开(公告)日:2019-10-24
申请号:US16387851
申请日:2019-04-18
IPC分类号: C07D405/14 , C07D405/12 , A61P35/00
摘要: Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with methyl modifying enzymes. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with methyl modifying enzymes.
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公开(公告)号:US09763922B2
公开(公告)日:2017-09-19
申请号:US14952821
申请日:2015-11-25
发明人: Marc Adler , Brian K. Albrecht , Sarah Bronner , Kevin X. Chen , Alexandre Côté , Terry Crawford , Patrick Cyr , Jackson Egen , Steven Kauder , Kwong Wah Lai , Jiangpeng Liao , Steven Magnuson , Jeremy Murray , Richard Pastor , F. Anthony Romero , Alexander M. Taylor , Vickie Hsiao-Wei Tsui , Fei Wang , Bing-Yan Zhu
IPC分类号: A61K31/437 , A61K31/4375 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/498 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5415 , A61K31/55 , C07D471/04 , C07D519/00 , A61K45/06
CPC分类号: A61K31/437 , A61K31/4375 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/498 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5415 , A61K31/55 , A61K45/06 , C07D471/04 , C07D519/00
摘要: The present invention relates to compounds of formula (I) or formula (II): and to salts thereof, wherein R1-R4 of formula (I) and R1-R3 of formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.
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公开(公告)号:US09522920B2
公开(公告)日:2016-12-20
申请号:US14313148
申请日:2014-06-24
发明人: Brian K. Albrecht , James Edmund Audia , Alexandre Côté , Victor S. Gehling , Jean-Christophe Harmange , Michael Charles Hewitt , Yves Leblanc , Christopher G. Nasveschuk , Alexander M. Taylor , Rishi G. Vaswani
IPC分类号: A61K31/55 , C07D498/04 , C07D498/14 , C07D498/20 , C07D498/22 , C07K14/47 , A61K31/424
CPC分类号: C07D498/04 , A61K31/424 , A61K31/55 , C07D498/14 , C07D498/20 , C07D498/22 , C07K14/4702
摘要: The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号:US11274095B2
公开(公告)日:2022-03-15
申请号:US16856454
申请日:2020-04-23
IPC分类号: C07D405/14 , C07D405/12 , A61P35/00
摘要: Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with methyl modifying enzymes. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with methyl modifying enzymes.
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公开(公告)号:US20200317651A1
公开(公告)日:2020-10-08
申请号:US16856454
申请日:2020-04-23
IPC分类号: C07D405/14 , A61P35/00 , C07D405/12
摘要: Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with methyl modifying enzymes. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with methyl modifying enzymes.
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公开(公告)号:US10526287B2
公开(公告)日:2020-01-07
申请号:US15567978
申请日:2016-04-22
发明人: Brian K. Albrecht , James Edmund Audia , Alexandre Côté , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Rishi G. Vaswani
IPC分类号: C07D211/22 , C07D211/26 , C07D309/20 , C07D215/44 , C07D317/28 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/10 , C07D405/04 , C07D239/30 , C07C215/44 , C07D417/06 , C07D263/32 , C07D205/12 , C07D207/32 , C07D211/36 , C07D213/64 , C07D305/06 , C07C255/58 , C07C211/09 , C07C211/36 , C07C211/40 , C07C215/14 , C07C217/08 , C07C229/10 , C07C229/38 , C07C229/46 , C07C233/41 , C07C237/06 , C07C255/24 , C07C215/42 , C07C255/30 , C07D211/58 , C07D211/76 , C07D213/38 , C07D213/69 , C07D213/73 , C07D295/195 , A61P35/00
摘要: Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with LSD1. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with LSD1.
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公开(公告)号:US20180290976A1
公开(公告)日:2018-10-11
申请号:US15567978
申请日:2016-04-22
发明人: Brian K. Albrecht , James Edmund Audia , Alexandre Côté , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Rishi G. Vaswani
IPC分类号: C07D211/26 , C07D211/58 , C07C211/40 , C07D213/38 , C07C229/10 , C07D213/73 , C07C255/58 , C07D211/76 , C07D401/06 , C07C215/42 , C07C233/41 , C07C217/08 , C07C237/06 , C07D295/195 , C07C229/38 , C07C255/30 , C07D213/69 , C07D305/06
CPC分类号: C07D211/26 , A61P35/00 , C07B2200/07 , C07C211/09 , C07C211/36 , C07C211/40 , C07C215/14 , C07C215/42 , C07C215/44 , C07C217/08 , C07C229/10 , C07C229/38 , C07C229/46 , C07C233/41 , C07C237/06 , C07C255/24 , C07C255/30 , C07C255/58 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2602/44 , C07D205/12 , C07D207/32 , C07D211/22 , C07D211/36 , C07D211/58 , C07D211/76 , C07D213/38 , C07D213/64 , C07D213/69 , C07D213/73 , C07D215/44 , C07D239/30 , C07D263/32 , C07D295/195 , C07D305/06 , C07D309/20 , C07D317/28 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/10 , C07D405/04 , C07D417/06
摘要: Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with LSD1. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with LSD1.
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公开(公告)号:US11459315B2
公开(公告)日:2022-10-04
申请号:US16762600
申请日:2018-11-08
发明人: Jehrod B. Brenneman , Alexandre Côté , Victor S. Gehling , Avinash Khanna , Julian R. Levell , Ludivine Moine
IPC分类号: C07D405/14 , C07D401/12 , C07D401/14 , C07D471/04
摘要: Provided are compounds of Formula (I): and pharmaceutically acceptable salts and compostions thereof, which are useful for treating a variety of conditions associated with methyl modifying enzymes.
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