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公开(公告)号：US10183009B2
公开(公告)日：2019-01-22
申请号：US15592013
申请日：2017-05-10
发明人： Brian K. Albrecht , Steven F. Bellon , Daniel J. Burdick , Alexandre Cote , Terry Crawford , Les A. Dakin , Vickie Hsiao-Wei Tsui , Michael Charles Hewitt , Yves LeBlanc , Steven R. Magnuson , Christopher G. Nasveschuk , F. Anthony Romero , Yong Tang , Alexander M. Taylor , Shumei Wang
IPC分类号： A61K31/40 , C07D471/04
摘要： The present invention relates to compounds of formula (I): and to salts thereof, wherein R1, R2, and Q have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of bromodomains. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various bromodomain-mediated disorders.
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公开(公告)号：US20170342067A1
公开(公告)日：2017-11-30
申请号：US15592017
申请日：2017-05-10
发明人： Brian K. Albrecht , Steven F. Bellon , Daniel J. Burdick , Alexandre Cote , Terry Crawford , Les A. Dakin , Vickie Hsiao-Wei Tsui , Michael Charles Hewitt , Yves LeBlanc , Steven R. Magnuson , Christopher G. Nasveschuk , Anthony F. Romero , Yong Tang , Alexander M. Taylor , Shumei Wang
IPC分类号： C07D471/04 , A61K45/06 , A61K31/4985 , A61K31/496 , A61K31/4545 , C07D519/00 , A61K31/437
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4545 , A61K31/496 , A61K31/4985 , A61K45/06 , C07D519/00
摘要： The present invention relates to compounds of formula (I): and to salts thereof, wherein R1, R2, and Q have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of bromodomains. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various bromodomain-mediated disorders.
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公开(公告)号：US20170340605A1
公开(公告)日：2017-11-30
申请号：US15592013
申请日：2017-05-10
发明人： Brian K. Albrecht , Steven F. Bellon , Daniel J. Burdick , Alexandre Cote , Terry Crawford , Les A. Dakin , Vickie Hsiao-Wei Tsui , Michael Charles Hewitt , Yves LeBlanc , Steven R. Magnuson , Christopher G. Nasveschuk , Anthony F. Romero , Yong Tang , Alexander M. Taylor , Shumei Wang
IPC分类号： A61K31/40 , C07D471/04
CPC分类号： A61K31/40 , C07D471/04
摘要： The present invention relates to compounds of formula (I): and to salts thereof, wherein R1, R2, and Q have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of bromodomains. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various bromodomain-mediated disorders.
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![BENZO [C] ISOXAZOLOAZEPINE BROMODOMAIN INHIBITORS AND USES THEREOF](/abs-image/US/2017/03/23/US20170079984A1/abs.jpg.150x150.jpg)
公开(公告)号：US20170079984A1
公开(公告)日：2017-03-23
申请号：US15277854
申请日：2016-09-27
IPC分类号： A61K31/55
CPC分类号： A61K31/55 , C07D498/04
摘要： The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US20190233375A1
公开(公告)日：2019-08-01
申请号：US16342741
申请日：2017-10-18
IPC分类号： C07D211/28 , C07D401/06 , C07D401/14
CPC分类号： C07D211/28 , C07D211/26 , C07D401/06 , C07D401/14
摘要： Provided herein are synthetic methods for the preparation of EZH2 inhibitors.
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公开(公告)号：US20170312292A1
公开(公告)日：2017-11-02
申请号：US15482581
申请日：2017-04-07
发明人： Anthony F. Romero , Steven R. Magnuson , Richard Pastor , Vickie Hsiao-Wei Tsui , Jeremy Murray , Terry Crawford , Daniel J. Burdick , Brian K. Albrecht , Alexandre Cote , Alexander M. Taylor , Christopher G. Nasveschuck , Yves LeBlanc , Michael Charles Hewitt , Kwong Wah Lai , Kevin Chen
IPC分类号： A61K31/55 , C07D403/04 , C07D243/24 , A61K31/5513 , C07D243/12 , C07D223/16 , C07D403/14 , C07D267/14
CPC分类号： A61K31/55 , A61K31/337 , A61K31/5513 , A61K45/06 , C07D223/16 , C07D243/12 , C07D243/24 , C07D267/14 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/14 , C07D405/04 , C07D405/12 , C07D413/04 , C07D413/10 , C07D471/04 , C07D495/04 , A61K2300/00
摘要： The present invention relates to compounds of formula (I): and to salts thereof, wherein A has any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.
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![BENZO [C] ISOXAZOLOAZEPINE BROMODOMAIN INHIBITORS AND USES THEREOF](/abs-image/US/2015/05/28/US20150148337A1/abs.jpg.150x150.jpg)
7.发明申请BENZO [C] ISOXAZOLOAZEPINE BROMODOMAIN INHIBITORS AND USES THEREOF 有权BENZO [C] ISOXAZOLOAZEPINE BROMODOMAIN抑制剂及其用途公开(公告)号：US20150148337A1
公开(公告)日：2015-05-28
申请号：US14405209
申请日：2013-06-06
IPC分类号： C07D498/04
CPC分类号： A61K31/55 , C07D498/04
摘要： The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作含溴结构域蛋白质的抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用所述组合物治疗各种疾病的方法。
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公开(公告)号：US10258603B2
公开(公告)日：2019-04-16
申请号：US15592012
申请日：2017-05-10
发明人： Brian K. Albrecht , Steven F. Bellon , Daniel J. Burdick , Alexandre Cote , Terry Crawford , Les A. Dakin , Vickie Hsiao-Wei Tsui , Michael Charles Hewitt , Yves LeBlanc , Steven R. Magnuson , Christopher G. Nasveschuk , F. Anthony Romero , Yong Tang , Alexander M. Taylor , Shumei Wang
IPC分类号： A61K31/40 , C07D471/04 , C07D519/00
摘要： The present invention relates to compounds of formula (I): and to salts thereof, wherein R1, R2, Rc, and Rd have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of bromodomains. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various bromodomain-mediated disorders.
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公开(公告)号：US10150767B2
公开(公告)日：2018-12-11
申请号：US15592017
申请日：2017-05-10
发明人： Brian K. Albrecht , Steven F. Bellon , Daniel J. Burdick , Alexandre Cote , Terry Crawford , Les A. Dakin , Vickie Hsiao-Wei Tsui , Michael Charles Hewitt , Yves LeBlanc , Steven R. Magnuson , Christopher G. Nasveschuk , Anthony F. Romero , Yong Tang , Alexander M. Taylor , Shumei Wang
IPC分类号： C07D471/04 , A61K31/437 , C07D519/00 , A61K31/4985 , A61K31/496 , A61K31/4545 , A61K45/06
摘要： The present invention relates to compounds of formula (I): and to salts thereof, wherein R1, R2, and Q have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of bromodomains. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various bromodomain-mediated disorders.
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![Benzo [C] isoxazoloazepine bromodomain inhibitors and uses thereof](/abs-image/US/2016/11/15/US09493483B2/abs.jpg.150x150.jpg)
10.发明授权公开(公告)号：US09493483B2
公开(公告)日：2016-11-15
申请号：US14405209
申请日：2013-06-06
IPC分类号： A61K31/55 , C07D498/04
CPC分类号： A61K31/55 , C07D498/04
摘要： The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
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