公开(公告)号：US20190275066A1

公开(公告)日：2019-09-12

申请号：US16422079

申请日：2019-05-24

申请人： Curemark, LLC

发明人： Joan M. Fallon ,  Richard Feltenstein

IPC分类号： A61K31/7016 ,  A61K31/047 ,  A61K31/045 ,  A61K31/7012

摘要： A treatment for autism in which an effective amount of lactulose is administered in order to bind excess ammonia in the gastrointestinal tract, the bloodstream, and the nervous system in order to prevent or reverse ammonia poisoning caused by the administration of certain antibiotics. Lactulose molecules in the colon are fermented by certain bacteria. The fermentation process lowers the colonic pH, and ammonia, in the form of ammonium ions, is used by the bacteria for amino acid and protein synthesis. This lowers the serum ammonia levels and reduces neurotoxicity.

公开(公告)号：US09345721B2

公开(公告)日：2016-05-24

申请号：US14087930

申请日：2013-11-22

申请人： Curemark LLC

发明人： Joan M. Fallon ,  Richard Feltenstein

IPC分类号： A61K31/7016 ,  A61K35/37 ,  A61K31/045 ,  A61K31/7012

CPC分类号： A61K31/7016 ,  A61K31/045 ,  A61K31/047 ,  A61K31/7012

摘要： A treatment for autism in which an effective amount of lactulose is administered in order to bind excess ammonia in the gastrointestinal tract, the bloodstream, and the nervous system in order to prevent or reverse ammonia poisoning caused by the administration of certain antibiotics. Lactulose molecules in the colon are fermented by certain bacteria. The fermentation process lowers the colonic pH, and ammonia, in the form of ammonium ions, is used by the bacteria for amino acid and protein synthesis. This lowers the serum ammonia levels and reduces neurotoxicity.

摘要翻译： 一种治疗自闭症，其中施用有效量的乳果糖以便结合胃肠道，血液和神经系统中的过量氨，以防止或逆转由施用某些抗生素引起的氨中毒。 结肠中的乳果糖分子被某些细菌发酵。 发酵过程降低了结肠pH，细菌形成氨离子的氨被氨基酸和蛋白质合成使用。 这降低了血清氨水平，降低了神经毒性。

公开(公告)号：US20160213697A1

公开(公告)日：2016-07-28

申请号：US15089842

申请日：2016-04-04

申请人： Curemark LLC

发明人： Joan M. Fallon ,  Richard Feltenstein

IPC分类号： A61K31/7016 ,  A61K31/047

CPC分类号： A61K31/7016 ,  A61K31/045 ,  A61K31/047 ,  A61K31/7012

摘要： A treatment for autism in which an effective amount of lactulose is administered in order to bind excess ammonia in the gastrointestinal tract, the bloodstream, and the nervous system in order to prevent or reverse ammonia poisoning caused by the administration of certain antibiotics. Lactulose molecules in the colon are fermented by certain bacteria. The fermentation process lowers the colonic pH, and ammonia, in the form of ammonium ions, is used by the bacteria for amino acid and protein synthesis. This lowers the serum ammonia levels and reduces neurotoxicity.

摘要翻译： 一种治疗自闭症，其中施用有效量的乳果糖以便结合胃肠道，血液和神经系统中的过量氨，以防止或逆转由施用某些抗生素引起的氨中毒。 结肠中的乳果糖分子被某些细菌发酵。 发酵过程降低了结肠pH，细菌形成氨离子的氨被氨基酸和蛋白质合成使用。 这降低了血清氨水平，降低了神经毒性。

公开(公告)号：US11033563B2

公开(公告)日：2021-06-15

申请号：US16422079

申请日：2019-05-24

申请人： Curemark, LLC

发明人： Joan M. Fallon ,  Richard Feltenstein

IPC分类号： A61K31/7016 ,  A61K31/045 ,  A61K31/7012 ,  A61K31/047

摘要： A treatment for autism in which an effective amount of lactulose is administered in order to bind excess ammonia in the gastrointestinal tract, the bloodstream, and the nervous system in order to prevent or reverse ammonia poisoning caused by the administration of certain antibiotics. Lactulose molecules in the colon are fermented by certain bacteria. The fermentation process lowers the colonic pH, and ammonia, in the form of ammonium ions, is used by the bacteria for amino acid and protein synthesis. This lowers the serum ammonia levels and reduces neurotoxicity.

公开(公告)号：US10350229B2

公开(公告)日：2019-07-16

申请号：US15089842

申请日：2016-04-04

申请人： Curemark, LLC

发明人： Joan M. Fallon ,  Richard Feltenstein

IPC分类号： A61K31/045 ,  A61K31/047 ,  A61K31/7012 ,  A61K31/7016

摘要： A treatment for autism in which an effective amount of lactulose is administered in order to bind excess ammonia in the gastrointestinal tract, the bloodstream, and the nervous system in order to prevent or reverse ammonia poisoning caused by the administration of certain antibiotics. Lactulose molecules in the colon are fermented by certain bacteria. The fermentation process lowers the colonic pH, and ammonia, in the form of ammonium ions, is used by the bacteria for amino acid and protein synthesis. This lowers the serum ammonia levels and reduces neurotoxicity.

公开(公告)号：US20210252031A1

公开(公告)日：2021-08-19

申请号：US17306614

申请日：2021-05-03

申请人： Curemark, LLC

发明人： Joan M. Fallon ,  Richard Feltenstein

IPC分类号： A61K31/7016 ,  A61K31/045 ,  A61K31/7012 ,  A61K31/047

摘要： A treatment for autism in which an effective amount of lactulose is administered in order to bind excess ammonia in the gastrointestinal tract, the bloodstream, and the nervous system in order to prevent or reverse ammonia poisoning caused by the administration of certain antibiotics. Lactulose molecules in the colon are fermented by certain bacteria. The fermentation process lowers the colonic pH, and ammonia, in the form of ammonium ions, is used by the bacteria for amino acid and protein synthesis. This lowers the serum ammonia levels and reduces neurotoxicity.

公开(公告)号：US20140187512A1

公开(公告)日：2014-07-03

申请号：US14087930

申请日：2013-11-22

申请人： Curemark LLC

发明人： Joan M. Fallon ,  Richard Feltenstein

IPC分类号： A61K31/7016

CPC分类号： A61K31/7016 ,  A61K31/045 ,  A61K31/047 ,  A61K31/7012

摘要： A treatment for autism in which an effective amount of lactulose is administered in order to bind excess ammonia in the gastrointestinal tract, the bloodstream, and the nervous system in order to prevent or reverse ammonia poisoning caused by the administration of certain antibiotics. Lactulose molecules in the colon are fermented by certain bacteria. The fermentation process lowers the colonic pH, and ammonia, in the form of ammonium ions, is used by the bacteria for amino acid and protein synthesis. This lowers the serum ammonia levels and reduces neurotoxicity.

摘要翻译： 一种治疗自闭症，其中施用有效量的乳果糖以便结合胃肠道，血液和神经系统中的过量氨，以防止或逆转由施用某些抗生素引起的氨中毒。 结肠中的乳果糖分子被某些细菌发酵。 发酵过程降低了结肠pH，细菌形成氨离子的氨被氨基酸和蛋白质合成使用。 这降低了血清氨水平，降低了神经毒性。