公开(公告)号：US20190048331A1

公开(公告)日：2019-02-14

申请号：US16078037

申请日：2017-02-22

Applicant: DA VOLTERRA ,  BIOASTER

Inventor： Jean DE GUNZBURG ,  Jean-Denis DOCQUIER

IPC: C12N9/86 ,  A61K9/00 ,  A61K38/50 ,  A61K31/496 ,  A61K31/546 ,  A61K31/407

Abstract: The present invention relates to an isolated polypeptide having beta-lactamase activity and nucleic acid sequences encoding the polypeptide. The isolated polypeptide of the invention is a VIM-2 variant with improved properties such as improved protease stability.

公开(公告)号：US20190062719A1

公开(公告)日：2019-02-28

申请号：US16078040

申请日：2017-02-22

Applicant: DA VOLTERRA ,  BIOASTER

Inventor： Jean DE GUNZBURG ,  Jean-Denis DOCQUIER

IPC: C12N9/86 ,  A61K45/06 ,  A61K38/50

Abstract: The present invention relates to an isolated polypeptide having beta-lactamase activity and nucleic acid sequences encoding the polypeptide. The isolated polypeptide of the invention is a VIM-2 variant with improved properties such as improved protease stability, stability in intestinal medium, improved activity against one or more antibiotics, improved specific activity and/or improved production in a host cell.