公开(公告)号：US20230386232A1

公开(公告)日：2023-11-30

申请号：US18031729

申请日：2021-10-19

Applicant: BIOMERIEUX ,  BIOASTER

Inventor： Pierre MAHÉ ,  Meriem EL AZAMI ,  Elodie DEGOUT-CHARMETTE ,  Zohreh SEDAGHAT ,  Quentin JOSSO ,  Fabian ROL

IPC: G06V20/69 ,  G06V10/774

CPC classification number: G06V20/698 ,  G06V20/695 ,  G06V10/774

Abstract: A method for classifying at least one input image containing a target particle in a sample, involves implementing, via data-processing of a client, steps of: (b) extracting a vector of characteristics of the target particle, the characteristics being numerical coefficients each associated with one elementary image of a set of elementary images each representing a reference particle, such that a linear combination of the elementary images weighted by the coefficients approximates the representation of the target particle in the input image; (c) classifying the input image depending on the extracted vector of characteristics.

公开(公告)号：US20210322988A1

公开(公告)日：2021-10-21

申请号：US17271010

申请日：2019-09-23

Applicant: BIOMÉRIEUX ,  BIOASTER

Inventor： Christophe VEDRINE ,  Yacine BOUNAB

IPC: B01L3/00 ,  G01N33/58 ,  G01N33/543 ,  G01N33/50 ,  G01N21/64

Abstract: The invention provides for a microfluidic droplet-based assay process and apparatus, wherein the process comprises the step of creating several assay droplets (18) containing paramagnetic particles (22, 22′), detectable markers (24), and at least one biological cell (10), wherein the paramagnetic particles (22, 22′) and the detectable markers (24) are able to bind with a target analyte (16) released by the cell, wherein the process includes storing several assay droplets along a horizontal storage plane, includes the generation of a magnetic field through the stored assay droplets, and includes detecting a physical characteristic of the detectable markers contained in a given assay droplet by optical imaging of the detectable markers, characterized in that the generation of a magnetic field generates a magnetic field such that the paramagnetic particles are attracted towards a lateral and inferior portion of the given stored assay droplet in which they are contained.

公开(公告)号：US10982205B2

公开(公告)日：2021-04-20

申请号：US16078040

申请日：2017-02-22

Applicant: DA VOLTERRA ,  BIOASTER

Inventor： Jean De Gunzburg ,  Jean-Denis Docquier

IPC: C12N9/86 ,  A61K31/43 ,  A61K38/50 ,  A61K45/06 ,  A61K38/00

Abstract: The present invention relates to an isolated polypeptide having beta-lactamase activity and nucleic acid sequences encoding the polypeptide. The isolated polypeptide of the invention is a Verona integron-encoded metallo-β-lactamase (VIM-2) variant with improved properties such as improved protease stability, stability in intestinal medium, improved activity against one or more antibiotics, improved specific activity and/or improved production in a host cell.

公开(公告)号：US20190086866A1

公开(公告)日：2019-03-21

申请号：US16095537

申请日：2017-04-27

Applicant: BIOMERIEUX ,  BIOASTER

Inventor： Alice Douet ,  Quentin Josso

IPC: G03H1/08 ,  G01N15/14 ,  C12Q1/20 ,  G03H1/04

CPC classification number: G03H1/0866 ,  C12Q1/20 ,  G01N15/1468 ,  G01N21/453 ,  G01N2015/1006 ,  G01N2015/1454 ,  G03H1/041 ,  G03H1/0443 ,  G03H2001/0447 ,  G03H2001/0452

Abstract: A device for acquisition of particles present in a sample includes a spatially coherent light source, an optical system, and an image sensor placed in the focal plane of the optical system. The image sensor is configured to capture an intensity image. A computational unit of the device is configured to construct a series of electromagnetic propagation matrices obtained for a plurality of defocusing offsets relative to a plane of focus of the optics. The computational unit is also configured to determine a first average focused electromagnetic matrix for the particles from the series of electromagnetic matrices, identifying at least one of the particles in the first electromagnetic matrix and storing the coordinates of said particle, and determining a second electromagnetic matrix at a distance of focus on a particle identified from the components of the series of electromagnetic matrices having the stored coordinates.

公开(公告)号：US20240020949A1

公开(公告)日：2024-01-18

申请号：US18031928

申请日：2021-10-19

Applicant: BIOMERIEUX ,  BIOASTER

Inventor： Pierre MAHÉ ,  Meriem EL AZAMI ,  Elodie DEGOUT-CHARMETTE ,  Zohreh SEDAGHAT ,  Quentin JOSSO ,  Fabian ROL

IPC: G06V10/764 ,  G06T7/10 ,  G06V10/24 ,  G06V10/44 ,  G06V10/774

CPC classification number: G06V10/764 ,  G06T7/10 ,  G06V10/24 ,  G06V10/44 ,  G06V10/774 ,  G06T2207/20084 ,  G06T2207/20132

Abstract: A method for classifying at least one input image representing a target particle in a sample, involves implementing, by data processing of a client, steps of: (b) extracting the characteristic map of the target particle by a convolutional neural network pre-trained on a base of public images; (c) classifying the input image according to the extracted characteristic map.

公开(公告)号：US20230250479A1

公开(公告)日：2023-08-10

申请号：US18014885

申请日：2021-07-05

Applicant: BIOMÉRIEUX ,  BIOASTER

Inventor： Laurence VACHOT ,  François MALLET ,  Guillaume MONNERET ,  Virginie MOUCADEL ,  Alexandre PACHOT ,  Estelle PERONNET ,  Thomas RIMMELÉ ,  Julien TEXTORIS ,  Fabienne VENET

IPC: C12Q1/6883

CPC classification number: C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/158

Abstract: An in vitro or ex vivo method for determining the risk of incidence of a care-related infection includes a step of measuring the expression of CD177 in a biological sample from said patient.

公开(公告)号：US20230220477A1

公开(公告)日：2023-07-13

申请号：US18014878

申请日：2021-07-05

Applicant: BIOMÉRIEUX ,  BIOASTER

Inventor： Laurence VACHOT ,  François MALLET ,  Guillaume MONNERET ,  Virginie MOUCADEL ,  Alexandre PACHOT ,  Estelle PERONNET ,  Thomas RIMMELÉ ,  Julien TEXTORIS ,  Fabienne VENET

IPC: C12Q1/6883 ,  C12Q1/6813 ,  C12Q1/686

CPC classification number: C12Q1/6883 ,  C12Q1/6813 ,  C12Q1/686 ,  C12Q2600/118

Abstract: An in vitro or ex vivo method for determining the risk of incidence of a healthcare-associated infection includes a step of measuring the expression of TAP2 in a biological sample from said patient.

公开(公告)号：US20210254165A1

公开(公告)日：2021-08-19

申请号：US17256811

申请日：2019-06-28

Applicant: BIOMÉRIEUX ,  BIOASTER ,  HOSPICES CIVILS DE LYON

Inventor： Marine MOMMERT ,  Olivier TABONE ,  Julien TEXTORIS ,  François MALLET

IPC: C12Q1/6883

Abstract: A method for determining in vitro or ex vivo the immune status of an individual, preferably a patient, including a step of detecting and/or quantifying the expression of one or more HERV/MaLR sequences in a biological sample of the individual. Also relates to the tools for implementing the method and to the uses thereof.

公开(公告)号：US20250092472A1

公开(公告)日：2025-03-20

申请号：US18580232

申请日：2022-07-19

Applicant: BIOMERIEUX ,  BIOASTER ,  HOSPICES CIVILS DE LYON

Inventor： François MALLET

IPC: C12Q1/70

Abstract: A method for in vitro or ex vivo assessment of the risk of complications in a patient admitted to a healthcare facility includes measuring the viral load of at least one torque teno virus (TTV) in a biological sample of the patient, wherein the patient is not undergoing immunosuppressive treatment.

公开(公告)号：US20230386233A1

公开(公告)日：2023-11-30

申请号：US18032399

申请日：2021-10-19

Applicant: BIOMERIEUX ,  BIOASTER

Inventor： Pierre MAHÉ ,  Meriem EL AZAMI ,  Elodie DEGOUT-CHARMETTE ,  Zohreh SEDAGHAT ,  Quentin JOSSO ,  Fabian ROL

IPC: G06V20/69 ,  G06V10/82 ,  G06V10/77

CPC classification number: G06V20/698 ,  G06V10/82 ,  G06V10/7715

Abstract: A method for classifying a sequence of input images representing a target particle in a sample over time, includes the following steps performed by the data processing of a client, namely: (b) concatenation of the input images in the sequence as a three-dimensional stack; (c) direct classification of the three-dimensional stack using a convolutional neural network, CNN