公开(公告)号：US20190169174A1

公开(公告)日：2019-06-06

申请号：US16310005

申请日：2017-06-15

Applicant: DAEWOONG PHARMACEUTICAL CO., LTD. ,  GREEN CROSS CORPORATION

Inventor： Hee-kyoon YOON ,  Se-Hwan PARK ,  Ji-Sung YOON ,  Soongyu CHOI ,  Hee Jeong SEO ,  Eun-Jung PARK ,  Younggyu KONG ,  Kwang-Seop SONG ,  Min Ju KIM ,  So Ok PARK

IPC: C07D409/04 ,  C07D407/04 ,  B01D9/00

Abstract: The present invention relates to an improved method for producing a diphenylmethane derivative which is effective as a sodium-dependent glucose cotransporter (SGLT) inhibitor, the method being carried out by means of a convergent synthesis method in which each major group is separately synthesized and then coupled. As such, in comparison to a linear synthesis method disclosed in existing documents, the synthesis pathway is compact and yield can be increased, and risk factors inherent in the linear synthesis pathway can be reduced. Furthermore, the crystal form of the compound produced according to the method has superb physicochemical characteristics, and thus can be effectively utilized in fields such as pharmaceutical manufacturing.