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公开(公告)号:US20080213814A1
公开(公告)日:2008-09-04
申请号:US11966436
申请日:2007-12-28
申请人: DANIELE GERION , Randy Storer , Hiroyuki Takei
发明人: DANIELE GERION , Randy Storer , Hiroyuki Takei
CPC分类号: C12Q1/001 , G01N21/554 , G01N33/54373 , G01N33/581
摘要: The present invention provides a method of detecting changes in the refractive index at the surface of a localized surface plasmon resonance (LSPR) detection system. The method includes generating an insoluble product from an enzymatic substrate using an immobilized enzyme, wherein the insoluble product accumulates at a LSPR supporting surface. The method also includes detecting changes in the reflected or transmitted light of the surface arising from the presence of the insoluble product using LSPR.
摘要翻译: 本发明提供一种检测局部表面等离子共振(LSPR)检测系统表面的折射率变化的方法。 该方法包括使用固定化酶从酶底物产生不溶性产物,其中不溶性产物在LSPR支撑表面积聚。 该方法还包括使用LSPR检测由不溶性产物的存在引起的表面的反射或透射光的变化。