公开(公告)号：US20240218062A1

公开(公告)日：2024-07-04

申请号：US18089812

申请日：2022-12-28

Applicant: DEVELOPMENT CENTER FOR BIOTECHNOLOGY ,  NATIONAL HEALTH RESEARCH INSTITUTES

Inventor： CHENG-CHOU YU ,  SHU-PING YEH ,  CHAO-YANG HUANG ,  SZU-LIANG LAI ,  SHIH-LIANG HSIAO ,  MEI-LING HOU ,  TZUNG-JIE YANG ,  WEI-TING SUN ,  LIANG-YU HSIA ,  ANDREW YUEH ,  CHIUNG-TONG CHEN ,  REN-HUANG WU ,  PEI-SHAN WU ,  HAN-SHU HU ,  TZU-CHIN WU ,  JIA-NI TIAN

IPC: C07K16/28 ,  A61P35/00 ,  C12N15/63

CPC classification number: C07K16/28 ,  A61P35/00 ,  C12N15/63 ,  C07K2317/24 ,  C07K2317/31

Abstract: A humanized anti-neurotensin receptor 1 (NTSR1) antibody or an antigen-binding fragment thereof. Also, a method for treating, prophylactic treating and/or preventing diseases and/or disorders caused by or related to NTSR1 activity and/or signaling, and a method or kit for detecting NTSR1 in a sample.

公开(公告)号：US20240209095A1

公开(公告)日：2024-06-27

申请号：US18522809

申请日：2023-11-29

Applicant: DEVELOPMENT CENTER FOR BIOTECHNOLOGY

Inventor： SHU-PING YEH ,  CHENG-CHOU YU ,  YU-HSUN LO ,  JIN-YU WANG ,  MEI-CHI CHAN ,  CHAO-YANG HUANG ,  SZU-LIANG LAI

IPC: C07K16/28 ,  A61K39/00 ,  A61K45/06 ,  A61K47/68 ,  A61P35/00

CPC classification number: C07K16/2827 ,  A61K45/06 ,  A61K47/6849 ,  A61P35/00 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/565

Abstract: The present disclosure relates to an anti-PD-L1 antibody or an antigen-binding fragment thereof, comprising: a heavy chain variable region sequence comprising the three CDRs with the sequences of SEQ ID NOs: 2 to 4, or 6 to 8; and a light chain variable region sequence comprising the three CDRs with the sequences of SEQ ID NOs: 10 to 12, or 14 to 16. The present disclosure also relates to a pharmaceutical composition and a method for detecting expression of PD-L1 in a sample.