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公开(公告)号：US20240218062A1
公开(公告)日：2024-07-04
申请号：US18089812
申请日：2022-12-28
Inventor： CHENG-CHOU YU , SHU-PING YEH , CHAO-YANG HUANG , SZU-LIANG LAI , SHIH-LIANG HSIAO , MEI-LING HOU , TZUNG-JIE YANG , WEI-TING SUN , LIANG-YU HSIA , ANDREW YUEH , CHIUNG-TONG CHEN , REN-HUANG WU , PEI-SHAN WU , HAN-SHU HU , TZU-CHIN WU , JIA-NI TIAN
CPC classification number: C07K16/28 , A61P35/00 , C12N15/63 , C07K2317/24 , C07K2317/31
Abstract: A humanized anti-neurotensin receptor 1 (NTSR1) antibody or an antigen-binding fragment thereof. Also, a method for treating, prophylactic treating and/or preventing diseases and/or disorders caused by or related to NTSR1 activity and/or signaling, and a method or kit for detecting NTSR1 in a sample.
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公开(公告)号：US20240209095A1
公开(公告)日：2024-06-27
申请号：US18522809
申请日：2023-11-29
Applicant: DEVELOPMENT CENTER FOR BIOTECHNOLOGY
Inventor： SHU-PING YEH , CHENG-CHOU YU , YU-HSUN LO , JIN-YU WANG , MEI-CHI CHAN , CHAO-YANG HUANG , SZU-LIANG LAI
CPC classification number: C07K16/2827 , A61K45/06 , A61K47/6849 , A61P35/00 , A61K2039/505 , C07K2317/24 , C07K2317/565
Abstract: The present disclosure relates to an anti-PD-L1 antibody or an antigen-binding fragment thereof, comprising: a heavy chain variable region sequence comprising the three CDRs with the sequences of SEQ ID NOs: 2 to 4, or 6 to 8; and a light chain variable region sequence comprising the three CDRs with the sequences of SEQ ID NOs: 10 to 12, or 14 to 16. The present disclosure also relates to a pharmaceutical composition and a method for detecting expression of PD-L1 in a sample.
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公开(公告)号：US20210386866A1
公开(公告)日：2021-12-16
申请号：US17339747
申请日：2021-06-04
Applicant: DEVELOPMENT CENTER FOR BIOTECHNOLOGY
Inventor： SHIH-HSIEN CHUANG , WEI-TING SUN , YING-SHUAN LAILEE , CHUN-LIANG LAI , WUN-HUEI LIN , WIN-YIN WEI , SHIH-CHONG TSAI , CHENG-CHOU YU , CHAO-YANG HUANG
IPC: A61K47/68 , A61K38/07 , A61K31/407 , A61K31/198 , A61K31/4745 , A61K47/54 , A61P35/00
Abstract: The present disclosure provides an immunoconjugate includes an antibody comprising an antigen-binding fragment that specifically binds to an epitope in mesothelin, N-glycan binding domain and an N-glycan; a linker linking to the N-glycan; and a payload A and a payload B conjugated to the linker, respectively; wherein the payload A and the payload B are the same or different. A pharmaceutical composition comprises the immunoconjugate and a method for treating cancer are also provided in the disclosure.
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公开(公告)号：US20170233480A1
公开(公告)日：2017-08-17
申请号：US15393534
申请日：2016-12-29
Applicant: DEVELOPMENT CENTER FOR BIOTECHNOLOGY
Inventor： JIANN-SHIUN LAI , LI-SHUANG AI , YAN-DA LAI , YEN-YU WU , YI-SAN TSAI , YI-JIUE TSAI , JUO-YU HUANG , CHENG-CHOU YU , CHUAN-LUNG HSU , CHIEN-TSUN KUAN , SZU-LIANG LAI , LI-YA WANG
IPC: C07K16/28 , G01N33/74 , C07K16/30 , A61K31/4439 , A61K51/10
CPC classification number: C07K16/2863 , A61K31/4439 , A61K47/6803 , A61K47/6849 , A61K51/1027 , A61K51/1096 , A61K2039/505 , A61K2039/507 , C07K14/71 , C07K16/005 , C07K16/2818 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/74 , G01N2333/71
Abstract: The present invention relates to an antibody or antigen-binding fragment thereof that bind human vascular endothelial growth factor receptor 2 (VEGFR-2). The present invention also relates to a method for inhibiting VEGFR-2-mediated signaling in a subject in need, a method for treating diseases and/or disorders caused by or related to VEGFR-2 activity and/or signaling in a subject afflicted with the diseases and disorders, a method for treating tumor in a subject afflicted with the tumor, a method for inhibiting cell proliferation of endothelial cells in a subject in need, and a method for detecting human vascular endothelial growth factor receptor in a sample.
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