专利检索 ap:("DEVELOPMENT CENTER FOR BIOTECHNOLOGY") AND inv:"Ying-Shuan Lailee" 第 1 页

1.

发明授权
Antibody-drug conjugates containing an anti-mesothelin antibody and uses thereof 有权

公开(公告)号：US11998613B2

公开(公告)日：2024-06-04

申请号：US17339747

申请日：2021-06-04

申请人： DEVELOPMENT CENTER FOR BIOTECHNOLOGY

发明人： Shih-Hsien Chuang , Wei-Ting Sun , Ying-Shuan Lailee , Chun-Liang Lai , Wun-Huei Lin , Win-Yin Wei , Shih-Chong Tsai , Cheng-Chou Yu , Chao-Yang Huang

IPC分类号： A61K47/68 , A61K47/54 , A61P35/00

CPC分类号： A61K47/6851 , A61K47/545 , A61K47/6803 , A61K47/6817 , A61K47/6889 , A61P35/00

摘要： The present disclosure provides an immunoconjugate includes an antibody comprising an antigen-binding fragment that specifically binds to an epitope in mesothelin, N-glycan binding domain and an N-glycan; a linker linking to the N-glycan; and a payload A and a payload B conjugated to the linker, respectively; wherein the payload A and the payload B are the same or different. A pharmaceutical composition comprises the immunoconjugate and a method for treating cancer are also provided in the disclosure.