公开(公告)号：US10947316B2

公开(公告)日：2021-03-16

申请号：US16010251

申请日：2018-06-15

Applicant: Development Center for Biotechnology

Inventor： Chao-Pin Lee ,  Shih-Hsien Chuang ,  Chuan-Lung Hsu ,  Yi-Jen Chen ,  Yu-Chin Nieh ,  Win-Yin Wei ,  Chia-Cheng Wu

IPC: A61P35/00 ,  A61K47/68 ,  A61K49/00 ,  G01N33/574 ,  A61K47/64 ,  A61K47/65 ,  A61K31/337 ,  A61K31/5365 ,  C07K16/30 ,  A61K39/395 ,  C07K16/28

Abstract: An immunoconjugate includes an anti-Globo H antibody, or a binding fragment thereof, and a therapeutic agent or a label, having the formula: Ab−(L−D)m, wherein Ab is the anti-Globo H antibody or the binding fragment thereof, L is a linker or a direct bond, D is the therapeutic agent or the label, and m is an integer from 1 to 8. The antibody may be a monoclonal antibody, which may be a humanized antibody. A method for treating a cancer includes administering to a subject in need of such treatment a pharmaceutically effective amount of an immunoconjugate containing an antibody against Globo H, or a binding fragment thereof, and a therapeutic agent covalently conjugated with the antibody.

公开(公告)号：US20190106507A1

公开(公告)日：2019-04-11

申请号：US16010251

申请日：2018-06-15

Applicant: Development Center for Biotechnology

Inventor： Chao-Pin Lee ,  Shih-Hsien Chuang ,  Chuan-Lung Hsu ,  Yi-Jen Chen ,  Yu-Chin Nieh ,  Win-Yin Wei ,  Chia-Cheng Wu

IPC: C07K16/30 ,  A61P35/00 ,  A61K47/65 ,  A61K47/64 ,  A61K47/68

Abstract: An immunoconjugate includes an anti-Globo H antibody, or a binding fragment thereof, and a therapeutic agent or a label, having the formula: Ab−(L−D)m, wherein Ab is the anti-Globo H antibody or the binding fragment thereof, L is a linker or a direct bond, D is the therapeutic agent or the label, and m is an integer from 1 to 8. The antibody may be a monoclonal antibody, which may be a humanized antibody. A method for treating a cancer includes administering to a subject in need of such treatment a pharmaceutically effective amount of an immunoconjugate containing an antibody against Globo H, or a binding fragment thereof, and a therapeutic agent covalently conjugated with the antibody.

公开(公告)号：US11998613B2

公开(公告)日：2024-06-04

申请号：US17339747

申请日：2021-06-04

Applicant: DEVELOPMENT CENTER FOR BIOTECHNOLOGY

Inventor： Shih-Hsien Chuang ,  Wei-Ting Sun ,  Ying-Shuan Lailee ,  Chun-Liang Lai ,  Wun-Huei Lin ,  Win-Yin Wei ,  Shih-Chong Tsai ,  Cheng-Chou Yu ,  Chao-Yang Huang

IPC: A61K47/68 ,  A61K47/54 ,  A61P35/00

CPC classification number: A61K47/6851 ,  A61K47/545 ,  A61K47/6803 ,  A61K47/6817 ,  A61K47/6889 ,  A61P35/00

Abstract: The present disclosure provides an immunoconjugate includes an antibody comprising an antigen-binding fragment that specifically binds to an epitope in mesothelin, N-glycan binding domain and an N-glycan; a linker linking to the N-glycan; and a payload A and a payload B conjugated to the linker, respectively; wherein the payload A and the payload B are the same or different. A pharmaceutical composition comprises the immunoconjugate and a method for treating cancer are also provided in the disclosure.

公开(公告)号：US11085062B2

公开(公告)日：2021-08-10

申请号：US16470807

申请日：2017-12-29

Applicant: DEVELOPMENT CENTER FOR BIOTECHNOLOGY

Inventor： Shih-Chong Tsai ,  Chun-Chung Lee ,  Meng-Sheng Lee ,  Ching-Yao Chen ,  Shih-Hsien Chuang ,  Yi-Jen Chen ,  Win-Yin Wei

IPC: C12P21/00 ,  A61K47/68 ,  C07K16/32

Abstract: A process for modifying glycoproteins is provided. The invention also provides a process for producing glycoprotein-payload conjugates, as well as the conjugates produced thereby.