公开(公告)号：US20160228559A1

公开(公告)日：2016-08-11

申请号：US15023736

申请日：2014-09-15

Applicant: Dow Global Technologies LLC

Inventor： Jaime Curtis-Fisk ,  True Rogers ,  Susan Jordan ,  Matthias Knarr ,  Meinolf Brackenhagen ,  Roland Adden

IPC: A61K47/38 ,  A61K47/02 ,  A61K31/167 ,  A61K9/00

CPC classification number: A61K47/38 ,  A61K9/0043 ,  A61K9/08 ,  A61K31/167 ,  A61K47/02

Abstract: A composition designed for application to a mucosa comprises i) a tonicity-adjusting agent, ii) an aqueous liquid diluent, and iii) 0.1 to 6 weight percent of a cellulose ether having a viscosity of up to 8000 mPa·s, wherein the cellulose ether has anhydroglucose units joined by 1-4 linkages and has methyl groups, hydroxyalkyl groups, and optionally alkyl groups being different from methyl as substituents such that hydroxyl groups of anhydroglucose units are substituted with methyl groups such that s23/s26 is 0.29 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 3-positions of the anhydroglucose unit are substituted with a methyl group and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 6-positions of the anhydroglucose unit are substituted with a methyl group.

Abstract translation: 设计用于粘膜的组合物包括i）张力调节剂，ii）含水液体稀释剂，和iii）0.1至6重量％的粘度高达8000mPa·s的纤维素醚，其中纤维素 醚具有通过1-4键连接的脱水葡萄糖单元，并且具有甲基，羟基烷基和任选的不同于作为取代基的甲基的烷基，使得脱水葡萄糖单元的羟基被甲基取代，使得s23 / s26为0.29以下， 其中s23是脱水葡萄糖单元的摩尔分数，其中只有脱水葡萄糖单元的2-和3-位上的两个羟基被甲基取代，并且其中s26是脱水葡萄糖单元的摩尔分数，其中只有两个羟基在 脱水葡萄糖单元的2-位和6-位被甲基取代。

公开(公告)号：US20160114047A1

公开(公告)日：2016-04-28

申请号：US14890617

申请日：2014-07-16

Applicant: DOW GLOBAL TECHNOLOGIES LLC

Inventor： Jaime Curtis-Fisk ,  Susan L. Jordan ,  True L. Rogers ,  Matthias Knarr ,  Meinolf Brackhagen ,  Roland Adden

IPC: A61K47/38 ,  A61K47/02 ,  A61K31/167 ,  A61K9/00

CPC classification number: A61K47/38 ,  A61K9/0043 ,  A61K31/167 ,  A61K47/02

Abstract: A composition designed for application to a mucosa comprises a tonicity-adjusting agent, a methylcellulose, and a liquid diluent, wherein the methylcellulose has anhydroglucose units joined by 1-4 linkages wherein hydroxy groups of anhydroglucose units are substituted with methyl groups such that s23/s26 is 0.36 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 3-positions of the anhydroglucose unit are substituted with methyl groups and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 6-positions of the anhydroglucose unit are substituted with methyl groups.

Abstract translation: 设计用于粘膜的组合物包括张力调节剂，甲基纤维素和液体稀释剂，其中甲基纤维素具有通过1-4键连接的脱水葡萄糖单元，其中脱水葡萄糖单元的羟基被甲基取代，使得s23 / s26为0.36以下，其中s23是脱水葡萄糖单元的摩尔分数，其中脱水葡萄糖单元的2-和3-位中的两个羟基仅被甲基取代，并且其中s26是脱水葡萄糖单元的摩尔分数，其中仅 脱水葡萄糖单元的2-和6-位上的两个羟基被甲基取代。

公开(公告)号：US20200147224A1

公开(公告)日：2020-05-14

申请号：US16743162

申请日：2020-01-15

Applicant: ROHM AND HAAS COMPANY ,  DOW GLOBAL TECHNOLOGIES LLC

Inventor： Joshua Katz ,  Yujing Tan ,  Emmett M Partain, III ,  Demetrius Dielman ,  Susan Jordan ,  Jaime Curtis-Fisk ,  Ryan DePuit

IPC: A61K47/38 ,  A61K9/08 ,  C08L1/28 ,  C08B11/193 ,  C08B11/14 ,  A61K9/00

Abstract: An aqueous solution comprising a cationic polymer dissolved in water, wherein said cationic polymer comprises a hydrophobic quaternary ammonium group covalently attached to a hydroxyethyl cellulose polymer backbone. Also, a method of delivering a drug to a mucosal surface in a living body, said method comprising applying the aqueous solution to said mucosal surface.