COMPOSITION FOR APPLICATION TO A MUCOSA COMPRISING A METHYLCELLULOSE
    2.
    发明申请
    COMPOSITION FOR APPLICATION TO A MUCOSA COMPRISING A METHYLCELLULOSE 审中-公开
    用于包含甲基纤维素的粘蛋白的组合物

    公开(公告)号:US20160114047A1

    公开(公告)日:2016-04-28

    申请号:US14890617

    申请日:2014-07-16

    CPC classification number: A61K47/38 A61K9/0043 A61K31/167 A61K47/02

    Abstract: A composition designed for application to a mucosa comprises a tonicity-adjusting agent, a methylcellulose, and a liquid diluent, wherein the methylcellulose has anhydroglucose units joined by 1-4 linkages wherein hydroxy groups of anhydroglucose units are substituted with methyl groups such that s23/s26 is 0.36 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 3-positions of the anhydroglucose unit are substituted with methyl groups and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 6-positions of the anhydroglucose unit are substituted with methyl groups.

    Abstract translation: 设计用于粘膜的组合物包括张力调节剂,甲基纤维素和液体稀释剂,其中甲基纤维素具有通过1-4键连接的脱水葡萄糖单元,其中脱水葡萄糖单元的羟基被甲基取代,使得s23 / s26为0.36以下,其中s23是脱水葡萄糖单元的摩尔分数,其中脱水葡萄糖单元的2-和3-位中的两个羟基仅被甲基取代,并且其中s26是脱水葡萄糖单元的摩尔分数,其中仅 脱水葡萄糖单元的2-和6-位上的两个羟基被甲基取代。

    INDUCING CASPASE ACTIVITY
    6.
    发明申请

    公开(公告)号:US20220054534A1

    公开(公告)日:2022-02-24

    申请号:US17435545

    申请日:2020-02-26

    Abstract: Embodiments are directed towards methods of inducing caspase activity. The methods include contacting a cell with a treatment compound represented by the following Formula (I): where R1 is selected from hydrogen or an alkyl group having from 1 to about 16 carbon atoms; R2 is selected from a hydroxyl group, a tosylate group, an alkoxy group of the formula OR3 where R3 is selected from an alkyl group having from 1 to about 16 carbon atoms, or an ester group of the formula OCOR4, where R4 is an alkyl group having from 1 to about 16 carbon atoms, and n is from 4 to 46,000, with the proviso that when R1 is hydrogen and R2 is a hydroxy group the treatment compound has a number average molecular weight from 10,100 to 2,000,0000 g/mol.

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