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1.发明申请METHODS OF TREATMENT USING WATER-SOLUBLE TRYPTOPHAN-CONTAINING PEPTIDES OBTAINED BY THE HYDROLYSIS OF HENS EGGS LYSOZYME 有权使用水溶液获得的水溶性TRYPTOPHAN包含肽治疗方法公开(公告)号：US20160082070A1
公开(公告)日：2016-03-24
申请号：US14955287
申请日：2015-12-01
Applicant: DSM IP ASSETS B.V.
Inventor： Andre Leonardus DE ROOS , Luppo EDENS , Rudolf Franciscus VAN BECKHOVEN , Alexander Lucia Leonardus DUCHATEAU , Joris KLOEK
Abstract: The present invention relates to a process to produce a composition comprising water-soluble peptides and having a Trp/LNAA ratio of more than 0.15, which comprises hydrolyzing lysozyme, preferably hen eggs lysozyme, to prepare a hydrolysate having a DH of between 5 and 45.
Abstract translation: 本发明涉及一种制备包含水溶性肽并且Trp / LNAA比大于0.15的组合物的方法，其包括水解溶菌酶，优选鸡蛋溶菌酶，以制备DH为5至45的水解产物 。
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2.发明申请公开(公告)号：US20140206036A1
公开(公告)日：2014-07-24
申请号：US14021652
申请日：2013-09-09
Applicant: DSM IP ASSETS B.V.
Inventor： Luppo EDENS , Robertus Antonius Mijndert VAN DER HOEVEN , Andre Leonardus DE ROOS , Melissa HARVEY
IPC: C12P21/06
CPC classification number: C12P21/06 , A23J3/346 , A61K38/482
Abstract: The present invention relates to a process for the proteolytic hydrolysis of a peptide or a polypeptide, said peptide or polypeptide comprising 4 to 40, preferably 5 to 35, amino acid residues and said peptide or polypeptide is not hydrolysable by subtilisin whereby said peptide or polypeptide is hydrolysed by a proline specific endo protease at a pH of 6.5 or lower, preferably 5.5 or lower and more preferably 5.0 or lower to hydrolyse said peptide or polypeptide.
Abstract translation: 本发明涉及肽或多肽的蛋白水解水解方法，所述肽或多肽包含4至40个，优选5至35个氨基酸残基，并且所述肽或多肽不能被枯草杆菌蛋白酶水解，因此所述肽或多肽 由pH6.5或更低，优选5.5或更低，更优选5.0或更低的脯氨酸特异性内切蛋白酶水解，以水解所述肽或多肽。
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