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公开(公告)号：US20160346364A1
公开(公告)日：2016-12-01
申请号：US15101630
申请日：2014-12-11
Applicant: DSM IP ASSETS B.V.
Inventor： Maaike Johanna BRUINS , Luppo EDENS , Lenneke NAN
CPC classification number: A61K38/488 , A21D8/042 , A23L5/25 , A23L29/06 , A23V2002/00 , A61K9/0053 , A61K38/482 , C12C5/004 , C12N9/62 , C12Y304/21026 , C12Y304/23018 , C12Y304/23019 , A61K2300/00
Abstract: This invention relates to a medicament or a dietary supplement comprising the Aspergillus niger aspergilloglutamic peptidase that is capable of hydrolyzing plant food allergens, and more particularly, alpha-amylase/trypsin inhibitors, thereby treating diseases due to an innate immune response in humans, and/or allowing to delay the onset of said diseases. The present invention relates to the discovery that the Aspergillus niger aspergilloglutamic peptidase is capable of hydrolyzing alpha-amylase/trypsin inhibitors that are present in wheat and related cereals said inhibitors being strong inducers of innate immune response. Furthermore, the present invention relates to a method for hydrolyzing alpha-amylase/trypsin inhibitors comprising incubating a composition for food consumption comprising alpha-amylase/trypsin inhibitors with the Aspergillus niger aspergilloglutamic peptidase, wherein the inhibitors are hydrolyzed. It also relates to an enzyme composition comprising the Aspergillus niger aspergilloglutamic peptidase and an additional enzyme, and to foodstuff comprising the Aspergillus niger aspergilloglutamic peptidase.
Abstract translation: 本发明涉及一种药物或膳食补充剂，其包含能够水解植物食物过敏原的黑曲霉曲霉菌肽酶，更具体地，涉及α-淀粉酶/胰蛋白酶抑制剂，从而治疗由于人的先天免疫应答引起的疾病，和/ 或允许延迟所述疾病的发作。 本发明涉及黑曲霉曲霉菌肽酶能够水解存在于小麦和相关谷物中的α-淀粉酶/胰蛋白酶抑制剂的发现，所述抑制剂是先天免疫应答的强诱导剂。 此外，本发明涉及水解α-淀粉酶/胰蛋白酶抑制剂的方法，包括将包含α-淀粉酶/胰蛋白酶抑制剂的食物组合物与黑曲霉曲霉菌肽酶一起孵育，其中所述抑制剂被水解。 它还涉及包含黑曲霉曲霉菌肽酶和另外的酶的酶组合物，以及包含黑曲霉曲霉菌肽酶的食品。
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公开(公告)号：US20160102300A1
公开(公告)日：2016-04-14
申请号：US14893186
申请日：2014-06-02
Applicant: DSM IP ASSETS B.V.
Inventor： Aida HISENI , Igor GALAEV , Luppo EDENS
Abstract: The present invention relates to immobilized proline-specific endoprotease, wherein the proline-specific endoprotease is immobilized on a carrier comprising methacrylate which has been functionalized with amino dimethylene, and wherein the carrier has a particle size range of 100 to 400 μm. The invention also relates to a process for producing beer comprising the steps of preparing a mash, fermenting the beer, and stabilizing the beer, wherein the beer is incubated with the immobilized proline-specific endoprotease.
Abstract translation: 本发明涉及固定化的脯氨酸特异性内切蛋白酶，其中脯氨酸特异性内切蛋白酶固定在已经用氨基二亚甲基官能化的甲基丙烯酸酯的载体上，其中载体的粒度范围为100-400μm。 本发明还涉及一种生产啤酒的方法，包括制备糊状物，发酵啤酒和稳定啤酒的步骤，其中啤酒与固定化的脯氨酸特异性内切蛋白酶一起温育。
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公开(公告)号：US20180177205A1
公开(公告)日：2018-06-28
申请号：US15889952
申请日：2018-02-06
Applicant: DSM IP ASSETS B.V.
Inventor： Petrus Jacobus Theodorus DEKKER , Luppo EDENS , Maximiliaan Peter Marie SWAAF , Albertus Alard VAN DIJK
CPC classification number: A23C9/127 , A23C9/1206 , A23C19/0328 , C12N9/16 , C12N9/2402 , C12N9/2468 , C12N9/2471 , C12N9/62 , C12Y301/06001 , C12Y302/01023 , C12Y302/01108
Abstract: The present invention describes a intracellular produced lactase, which comprises less than 40 units arylsulfatase activity per NLU of lactase activity. The invention also provides a process comprising treating a substrate with an enzyme preparation, wherein the enzyme preparation is substantially free from arylsulfatase.
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4.发明申请公开(公告)号：US20160302446A1
公开(公告)日：2016-10-20
申请号：US15102037
申请日：2014-12-11
Applicant: DSM IP ASSETS B.V. , NOVOZYMES A/S
Inventor： Maaike Johanna BRUINS , Luppo EDENS , Nan LENEKE
IPC: A23K20/189 , A23K20/20 , A61K38/48 , A23K50/30 , A23K50/75 , A23K20/174 , A23K10/14
CPC classification number: A23K20/189 , A23K10/14 , A23K20/174 , A23K20/30 , A23K50/30 , A23K50/75 , A61K38/488 , C12Y304/23019
Abstract: This invention relates to the use of the Aspergillus niger aspergilloglutamic peptidase in a feed composition containing cereals, pulses, oilseeds, and/or tubers to improve animal performance, reduce nitrogen excretion and/or reduce intestinal inflammation. Furthermore, the present invention relates to a feed composition or a feed additive comprising the Aspergillus niger aspergilloglutamic peptidase. The present invention relates to the discovery that the Aspergillus niger aspergilloglutamic peptidase is capable of efficiently hydrolyzing alpha-amylase/trypsin inhibitors that are present in wheat, barley and related cereal species, as well as hydrolyzing trypsin inhibitors that are present in pulses, oilseeds, and tubers. Furthermore, the present invention relates to a method of improving animal performance comprising improving feed conversion ratio, and/or improving daily weight gain, and/or reducing intestinal inflammation, and/or reducing nitrogen excretion in an animal fed a feed stuff containing alpha-amylase and/or trypsin inhibitors, comprising orally administering a sufficient amount of the Aspergillus niger aspergilloglutamic peptidase. It also relates to the pretreatment of feedstuff with the Aspergillus niger aspergilloglutamic peptidase.
Abstract translation: 本发明涉及黑曲霉曲霉菌肽酶在含有谷物，豆类，油籽和/或块茎的饲料组合物中的用途，以改善动物性能，减少氮排泄和/或减少肠道炎症。 此外，本发明涉及包含黑曲霉曲霉菌肽酶的饲料组合物或饲料添加剂。 本发明涉及黑曲霉曲霉肠肽酶能够有效水解存在于小麦，大麦和相关谷类物种中的α-淀粉酶/胰蛋白酶抑制剂以及水解存在于脉冲，油籽中的胰蛋白酶抑制剂的发现， 和块茎。 此外，本发明涉及一种改善动物性能的方法，包括改善饲料转化率，和/或改善每日体重增加，和/或减少肠道炎症，和/或减少饲喂含α-淀粉样蛋白饲料的动物的氮排泄， 淀粉酶和/或胰蛋白酶抑制剂，包括口服施用足量的黑曲霉曲霉菌肽酶。 它还涉及用黑曲霉曲霉菌肽酶预处理饲料。
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公开(公告)号：US20160175457A1
公开(公告)日：2016-06-23
申请号：US14906600
申请日：2014-09-12
Applicant: DSM IP ASSETS B.V.
Inventor： Luppo EDENS , Peter Jan Leonard Mario QUAEDFLIEG , James P. PARAKKA , Petrus Johannes HERMSEN , Dennis HEEMSKERK , Michiel AKEROYD
IPC: A61K47/48 , A61K31/728 , A61K9/00
CPC classification number: A61K38/08 , A61K9/0051 , A61K31/728 , A61K47/65 , G02B1/043
Abstract: The present invention relates to a composition, such as a coating composition, comprising a peptide linked to a lubricant, wherein the peptide is cleavable by one or more proteinases present in tear fluid. The invention further relates to an ocular device comprising said composition, such as a preformed contact lens.
Abstract translation: 本发明涉及包含与润滑剂连接的肽的组合物，例如涂料组合物，其中所述肽可通过存在于泪液中的一种或多种蛋白酶切割。 本发明还涉及一种包括所述组合物的眼部装置，例如预成型的隐形眼镜。
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Patent Agency Ranking
公开(公告)号：US20150208682A1
公开(公告)日：2015-07-30
申请号：US14683262
申请日：2015-04-10
Applicant: DSM IP ASSETS B.V.
Inventor： Petrus Jacobus Theodorus DEKKER , Luppo EDENS , Maximiliaan Peter Marie SWAAF , Albertus Alard VAN DIJK
IPC: A23C9/127 , A23C19/032 , C12N9/24
CPC classification number: A23C9/127 , A23C9/1206 , A23C19/0328 , C12N9/16 , C12N9/2402 , C12N9/2468 , C12N9/2471 , C12N9/62 , C12Y301/06001 , C12Y302/01023 , C12Y302/01108
Abstract: The present invention describes a intracellular produced lactase, which comprises less than 40 units arylsulfatase activity per NLU of lactase activity. The invention also provides a process comprising treating a substrate with an enzyme preparation, wherein the enzyme preparation is substantially free from arylsulfatase.
Abstract translation: 本发明描述了细胞内产生的乳糖酶，其包含每NLU乳糖酶活性少于40个芳基硫酸酯酶活性。 本发明还提供了一种方法，其包括用酶制剂处理底物，其中所述酶制剂基本上不含芳基硫酸酯酶。
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公开(公告)号：US20150299057A1
公开(公告)日：2015-10-22
申请号：US14443820
申请日：2013-11-21
Applicant: DSM IP ASSETS B.V.
Inventor： Jurgen SCHEERDER , Gerardus Cornelis OVERBEEK , Luppo EDENS
Abstract: The present invention relates to a seed treatment composition comprising a waterborne resin and a water dispersible plant protein. The invention is further directed to the production of these compositions and to the uses of these compositions.
Abstract translation: 本发明涉及包含水性树脂和水分散性植物蛋白质的种子处理组合物。 本发明进一步涉及这些组合物的生产和这些组合物的用途。
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8.发明申请公开(公告)号：US20140206036A1
公开(公告)日：2014-07-24
申请号：US14021652
申请日：2013-09-09
Applicant: DSM IP ASSETS B.V.
Inventor： Luppo EDENS , Robertus Antonius Mijndert VAN DER HOEVEN , Andre Leonardus DE ROOS , Melissa HARVEY
IPC: C12P21/06
CPC classification number: C12P21/06 , A23J3/346 , A61K38/482
Abstract: The present invention relates to a process for the proteolytic hydrolysis of a peptide or a polypeptide, said peptide or polypeptide comprising 4 to 40, preferably 5 to 35, amino acid residues and said peptide or polypeptide is not hydrolysable by subtilisin whereby said peptide or polypeptide is hydrolysed by a proline specific endo protease at a pH of 6.5 or lower, preferably 5.5 or lower and more preferably 5.0 or lower to hydrolyse said peptide or polypeptide.
Abstract translation: 本发明涉及肽或多肽的蛋白水解水解方法，所述肽或多肽包含4至40个，优选5至35个氨基酸残基，并且所述肽或多肽不能被枯草杆菌蛋白酶水解，因此所述肽或多肽 由pH6.5或更低，优选5.5或更低，更优选5.0或更低的脯氨酸特异性内切蛋白酶水解，以水解所述肽或多肽。
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公开(公告)号：US20230225346A1
公开(公告)日：2023-07-20
申请号：US18149923
申请日：2023-01-04
Applicant: DSM IP ASSETS B.V.
Inventor： Petrus Jacobus Theodorus DEKKER , Luppo EDENS , Maximiliaan Peter Marie DE SWAAF , Albertus Alard VAN DIJK
CPC classification number: A23C9/127 , C12N9/16 , C12N9/2471 , C12Y301/06001 , A23C9/1206 , C12N9/62 , C12Y302/01023 , C12N9/2468 , A23C19/0328 , C12N9/2402 , C12Y302/01108
Abstract: The present invention describes a intracellular produced lactase, which comprises less than 40 units arylsulfatase activity per NLU of lactase activity. The invention also provides a process comprising treating a substrate with an enzyme preparation, wherein the enzyme preparation is substantially free from arylsulfatase.
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10.发明申请METHODS OF TREATMENT USING WATER-SOLUBLE TRYPTOPHAN-CONTAINING PEPTIDES OBTAINED BY THE HYDROLYSIS OF HENS EGGS LYSOZYME 有权使用水溶液获得的水溶性TRYPTOPHAN包含肽治疗方法公开(公告)号：US20160082070A1
公开(公告)日：2016-03-24
申请号：US14955287
申请日：2015-12-01
Applicant: DSM IP ASSETS B.V.
Inventor： Andre Leonardus DE ROOS , Luppo EDENS , Rudolf Franciscus VAN BECKHOVEN , Alexander Lucia Leonardus DUCHATEAU , Joris KLOEK
Abstract: The present invention relates to a process to produce a composition comprising water-soluble peptides and having a Trp/LNAA ratio of more than 0.15, which comprises hydrolyzing lysozyme, preferably hen eggs lysozyme, to prepare a hydrolysate having a DH of between 5 and 45.
Abstract translation: 本发明涉及一种制备包含水溶性肽并且Trp / LNAA比大于0.15的组合物的方法，其包括水解溶菌酶，优选鸡蛋溶菌酶，以制备DH为5至45的水解产物 。
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