公开(公告)号：US20210180103A1

公开(公告)日：2021-06-17

申请号：US16065274

申请日：2016-12-20

Applicant: DSM IP ASSETS B.V.

Inventor： Hans-Peter HOHMANN ,  Regina LEBER ,  Martin LEHMANN ,  Corinna ODAR ,  Barbara PETSCHACHER ,  Harald PICHLER ,  Birgit PLOIER

IPC: C12P33/16 ,  C12N9/02 ,  C12N9/10 ,  C12N1/16

Abstract: The present invention is related to production of a sterol mix in a modified yeast cell, wherein the amount of zymosterol present in said mix is dramatically reduced or abolished via modification of sterol acyltransferase activity within said yeast. The modified yeast cell can be used for production of vitamin D3 or derivatives and/or metabolites thereof.