公开(公告)号：US20220280462A1

公开(公告)日：2022-09-08

申请号：US17637996

申请日：2020-08-26

Applicant: DSM IP ASSETS B.V.

Inventor： Denis KARPUKHIN ,  Zhenbo MA ,  Conroy Clive SALMON

IPC: A61K31/192 ,  A61K31/51 ,  A61K31/675 ,  A61K31/714 ,  A61K9/20 ,  A61K9/48

Abstract: The present invention relates to a solid oral dosage form comprising naproxen and vitamin B1. Preferably, it is a solid oral dosage form for use in the treatment of pain such as low back pain. It is a fixed-dose combination (FDC) which increases patient compliance. The method of preparing such solid oral dosage form comprises the preparation of naloxone granules, the intragranular addition of vitamin B1 and optionally the extragranular addition of other B-vitamins such vitamin B6 and vitamin B12.

公开(公告)号：US20220378728A1

公开(公告)日：2022-12-01

申请号：US17637971

申请日：2020-08-26

Applicant: DSM IP ASSETS B.V.

Inventor： Denis KARPUKHIN ,  Zhenbo MA ,  Conroy Clive SALMON

IPC: A61K31/192 ,  A61K9/20 ,  A61K31/4415 ,  A61K31/51 ,  A61K31/714

Abstract: The present invention relates to a solid oral dosage form comprising naproxen and vitamin B6. Preferably, it is a solid oral dosage form for use in the treatment of pain such as low back pain. It is a fixed-dose combination (FDC) which increases patient compliance. The method of preparing such solid oral dosage form comprises the extragranular addition of vitamin B6 to an intragranular composition, wherein said intragranular composition comprises naproxen or a pharmaceutically acceptable salt thereof and at least one binder.

公开(公告)号：US20220280461A1

公开(公告)日：2022-09-08

申请号：US17637992

申请日：2020-08-26

Applicant: DSM IP ASSETS B.V.

Inventor： Denis KARPUKHIN ,  Zhenbo MA ,  Conroy Clive SALMON

IPC: A61K31/192 ,  A61K31/714 ,  A61K31/675 ,  A61K9/00 ,  A61K9/20 ,  A61K9/48

Abstract: The present invention relates to a solid oral dosage form comprising naproxen and vitamin B12. Preferably, it is a solid oral dosage form for use in the treatment of pain such as low back pain. It is a fixed-dose combination (FDC) which increases patient compliance. The method of preparing such solid oral dosage form comprises the extragranular addition of vitamin B12 to an intragranular composition, wherein said intragranular composition comprises naproxen or a pharmaceutically acceptable salt thereof and at least one binder.

公开(公告)号：US20210015753A1

公开(公告)日：2021-01-21

申请号：US16766893

申请日：2018-11-22

Applicant: DSM IP ASSETS B.V.

Inventor： Maria EBENRETH ,  Denis KARPUKHIN ,  Marcel MOONEN

IPC: A61K9/19 ,  A61K9/50 ,  A61K31/202 ,  A23L33/12

Abstract: The present invention relates to a freeze dried multiparticulate solid dosage form (1) that contains a plurality of microcapsules (2) having a core (2a) and a shell (2b) that are embedded in a freeze-dried, edible matrix (3). Microcapsules (2) contain an active ingredient which may be a pharmaceutical drug and/or a micronutrient. The solid dosage form may be a tablet, a wafer or even a crispy snack. A method for preparing such dosage forms is also disclosed.