公开(公告)号：US20220186264A1

公开(公告)日：2022-06-16

申请号：US17437566

申请日：2020-03-11

Applicant: DSM IP ASSETS B.V.

Inventor： Herman Jan PEL ,  Maaike APPELDOORN ,  Rolf POLDERMANS

IPC: C12P1/02 ,  C12N1/14 ,  C12N9/24

Abstract: The invention relates to a process for producing a fermentation broth by culturing a microorganism.

公开(公告)号：US20220380813A1

公开(公告)日：2022-12-01

申请号：US17774361

申请日：2020-11-09

Applicant: DSM IP ASSETS B.V.

Inventor： Ingrid Maria VUGT-VAN LUTZ ,  Hans Marinus Charles Johannes DE BRUIJN ,  Rolf POLDERMANS

IPC: C12P7/06 ,  C12N1/18 ,  C12N15/52

Abstract: The invention relates to a process for the production of ethanol, the process comprising fermenting of a carbon source composition with a recombinant yeast,
wherein the carbon source composition comprises at least glucose and arabinose; and wherein the recombinant yeast comprises arabinose isomerase activity, ribulokinase activity, ribulose phosphate epimerase activity, glycerol uptake activity and glycerol conversion capacity; and wherein the recombinant yeast further comprises a genetic modification leading to the reduction, downregulation, inhibition and/or elimination of the activity of a homologous protein with glycerol-efflux activity; and wherein each of the glucose and the arabinose is converted into ethanol. In addition, the invention relates to a recombinant yeast that can be used in such a process.

公开(公告)号：US20200181657A1

公开(公告)日：2020-06-11

申请号：US16063810

申请日：2016-12-22

Applicant: DSM IP ASSETS B.V.

Inventor： Alrik Pieter LOS ,  Zheng ZHAO ,  René VERWAAL ,  Jacobus Thomas PRONK ,  Rolf POLDERMANS

IPC: C12P7/46 ,  C12N9/02 ,  C12N9/04 ,  C12N15/81

Abstract: The present invention relates to a host cell which is capable of producing a dicarboxylic acid and which comprises at least one genetic modification in its genome resulting in the deficiency of at least one enzymatic step catalysing the oxidation of a cofactor. The invention also relates to a process for producing a dicarboxylic acid, which method comprises fermenting such a host cell in a suitable fermentation medium and producing the dicarboxylic acid.