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公开(公告)号：US20190194692A1
公开(公告)日：2019-06-27
申请号：US15541665
申请日：2016-01-06
Applicant: DSM IP ASSETS B.V. , RIJKSUNIVERSITEIT GRONINGEN
Inventor： Bernard MEIJRINK , René VERWAAL , Bianca Elisabeth Maria GIELESEN , Johannes Andries ROUBOS , Carsten POHL , Arnold Jacob Mattieu DRIESSEN , Roelof Ary Lans BOVENBERG , Yvonne Irene NYGÅRD
CPC classification number: C12N15/902 , C12N9/22 , C12N15/11 , C12N2310/20 , C12N2800/80
Abstract: The present invention relates to the field of molecular biology and cell biology. More specifically, the present invention relates to a CRISPR-CAS system for a filamentous fungal host cell.
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公开(公告)号：US20200172934A1
公开(公告)日：2020-06-04
申请号：US16780063
申请日：2020-02-03
Applicant: DSM IP ASSETS B.V.
Inventor： René VERWAAL , Bernard MEIJRINK , Nathalie WIESSENHAAN , Brenda VONK , Johannes Andries ROUBOS
Abstract: The present invention relates to the field of molecular biology and cell biology. More specifically, the present invention relates to a CRISPR-CAS system for a yeast host cell.
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公开(公告)号：US20230287436A1
公开(公告)日：2023-09-14
申请号：US18187937
申请日：2023-03-22
Applicant: DSM IP ASSETS B.V. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventor： Eric Mosher YOUNG , Amar GHODASARA , René VERWAAL , Johannes Andries ROUBOS , Bianca Elisabeth Maria GIELESEN , Brenda VONK , Alec A.K. NIELSEN , Christopher Ashby VOIGT
CPC classification number: C12N15/66 , C12N9/22 , C12N2310/20
Abstract: The present invention relates to the field of molecular biology and cell biology. More specifically, the present invention relates to a guide-RNA expression system for a eukaryotic host cell.
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公开(公告)号：US20200165637A1
公开(公告)日：2020-05-28
申请号：US16780389
申请日：2020-02-03
Applicant: DSM IP ASSETS B.V.
Inventor： Bernard MEIJRINK , René VERWAAL , Bianca Elisabeth Maria GIELESEN , Johannes Andries ROUBOS
Abstract: The present invention relates to the field of molecular biology and cell biology. More specifically, the present invention relates to a CRISPR-CAS system for a lipolytic yeast host cell.
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公开(公告)号：US20190185843A1
公开(公告)日：2019-06-20
申请号：US16319746
申请日：2016-12-15
Applicant: DSM IP ASSETS B.V.
CPC classification number: C12N15/102 , C12N15/111 , C12N15/902 , C12N2310/20 , C12Q2521/301
Abstract: The present invention is based on the advantageous use of single-stranded oligonucleotides in the in vivo (within a cell) assembly of double-stranded oligonucleotides into a single double-stranded nucleic acid construct.The present invention relates to the use of at least a first and a second single-stranded oligonucleotide in the assembly within a cell of at least two double-stranded nucleic acid molecules into a single double-stranded nucleic acid construct of pre-determined sequence, wherein the first and second single-stranded oligonucleotide are essentially complementary to each other.
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Patent Agency Ranking
公开(公告)号：US20220064607A1
公开(公告)日：2022-03-03
申请号：US17419079
申请日：2019-12-30
Applicant: DSM IP Assets B.V.
Inventor： Peter Louis HOUSTON , René Marcel DE JONG , Valmik Kanubhai VYAS , René VERWAAL , Jenna McMAHON , Anna SYMBOR-NAGRABSKA
Abstract: The present invention is related to production of retinyl acetate generated via enzymatic conversion of retinol, said process including the use of modified enzymes with improved activity.
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公开(公告)号：US20200181657A1
公开(公告)日：2020-06-11
申请号：US16063810
申请日：2016-12-22
Applicant: DSM IP ASSETS B.V.
Inventor： Alrik Pieter LOS , Zheng ZHAO , René VERWAAL , Jacobus Thomas PRONK , Rolf POLDERMANS
Abstract: The present invention relates to a host cell which is capable of producing a dicarboxylic acid and which comprises at least one genetic modification in its genome resulting in the deficiency of at least one enzymatic step catalysing the oxidation of a cofactor. The invention also relates to a process for producing a dicarboxylic acid, which method comprises fermenting such a host cell in a suitable fermentation medium and producing the dicarboxylic acid.
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公开(公告)号：US20200032252A1
公开(公告)日：2020-01-30
申请号：US16500717
申请日：2018-04-04
Applicant: DSM IP ASSETS B.V.
Abstract: The present invention relates to the field of molecular biology and cell biology. More specifically, the present invention relates to a self-guiding integration construct for a genome editing system.
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公开(公告)号：US20190055544A1
公开(公告)日：2019-02-21
申请号：US15741985
申请日：2016-07-06
Applicant: DSM IP ASSETS B.V.
Inventor： Paulus Petrus DE WAAL , Johannes Andries ROUBOS , Paul KLAASSEN , René VERWAAL
Abstract: The present invention relates relates to a CRISPR-CAS system for a host cell, in particular to a method to produce a circular vector comprising one or more guide-polynucleotide expression cassettes, wherein said one or more guide-polynucleotide expression cassettes comprise a polynucleotide encoding a guide-polynucleotide operably linked to one or more control sequences which direct the expression of said guide-polynucleotide in a host cell, wherein said guide-polynucleotide comprises a guide-sequence that essentially is the reverse complement of a target-polynucleotide in a host cell and wherein the guide-polynucleotide can direct binding of a Cas protein at a target-polynucleotide in a host cell to form a CRISPR-Cas complex, in vivo.
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公开(公告)号：US20180010151A1
公开(公告)日：2018-01-11
申请号：US15541431
申请日：2016-01-06
Applicant: DSM IP ASSETS B.V.
Inventor： René VERWAAL , Bernard MEIJRINK , Nathalie WIESSENHAAN , Brenda VONK , Johannes Andries ROUBOS
IPC: C12N15/90 , C12N15/113 , C12N9/22 , C12P23/00
CPC classification number: C12N15/905 , C12N9/22 , C12N15/102 , C12N15/113 , C12N15/81 , C12N15/902 , C12N2310/20 , C12P23/00
Abstract: The present invention relates to the field of molecular biology and cell biology. More specifically, the present invention relates to a CRISPR-CAS system for a yeast host cell.
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