公开(公告)号：US20160168110A1

公开(公告)日：2016-06-16

申请号：US14902661

申请日：2014-07-03

Applicant: DSM IP ASSETS B.V.

Inventor： Jonthan Alan MEDLOCK ,  Ulla LETINOIS ,  Thomas NETSCHER ,  Wemer BONRATH

IPC: C07D311/22

CPC classification number: C07D311/22 ,  C07B2200/09

Abstract: The present invention relates to a synthesis of chromanones or chromanes in a stereospecific matter in view of the 2-position in the chromanone or chromane ring. It has been found that this synthesis is particularly possible in the presence of a chiral compound of a specific type and of at least one Bransted acid or in the presence a specific chiral compound having a Bransted acid functional group in the molecule.

Abstract translation: 本发明涉及在苯并二氢吡喃酮或苯并二氢吡喃环中2-位的立体特异性物质中的色满酮或色烷的合成。 已经发现，该合成在特定类型的手性化合物和至少一种布氏酸的存在下或在分子中存在具有布朗斯台酸官能团的特定手性化合物的情况下是特别有可能的。