公开(公告)号：US20240209132A1

公开(公告)日：2024-06-27

申请号：US18556213

申请日：2022-04-26

申请人： DSM IP ASSETS B.V.

发明人： Werner BONRATH ,  Rolf KUENZI ,  Thomas NETSCHER

IPC分类号： C08F232/06 ,  C08F2/06 ,  C08F4/32 ,  C08F4/44

CPC分类号： C08F232/06 ,  C08F2/06 ,  C08F4/32 ,  C08F4/44

摘要： The present invention relates to the formation of compound of the formula (I) by reacting 2,3,6-trimethylhydroquinone or a protected derivative thereof with the unsaturated alcohol of formula (IIIa) or (IIIb) in the presence of Gd(OTf)3 or Tm(OTf)3 or Al(OTf)3 or Y(OTf)3 or Fe(OTf)2 or camphorsulfonic acid or BiCl3 as acidic catalyst.

公开(公告)号：US20170305827A1

公开(公告)日：2017-10-26

申请号：US15518355

申请日：2015-10-15

申请人： DSM IP ASSETS B.V.

发明人： Werner BONRATH ,  Thomas NETSCHER ,  Jan SCHUETZ ,  Bettina WUESTENBERG

IPC分类号： C07C45/51 ,  C07C11/12 ,  C07C47/225 ,  C07C5/23 ,  C07C2601/16

CPC分类号： C07C45/512 ,  C07C5/23 ,  C07C11/12 ,  C07C29/42 ,  C07C47/225 ,  C07C2523/46 ,  C07C2527/14 ,  C07C2601/16 ,  C07C33/14

摘要： The present invention relates to an improved method for producing specific α, β-unsaturated aldehydes.

公开(公告)号：US20240059650A1

公开(公告)日：2024-02-22

申请号：US18256992

申请日：2021-12-13

申请人： DSM IP ASSETS B.V. ,  UNIVERSITÄT BASEL

发明人： Werner BONRATH ,  Thomas BUCHHOLZ ,  Thomas NETSCHER ,  Jan SCHUETZ ,  Christof SPARR

IPC分类号： C07C407/00

CPC分类号： C07C407/00 ,  C07C2601/16

摘要： The present invention relates to the photooxidation of 2,4,6-trimethyl-phenol to yield 4-hydroperoxy-2,4,6-trimethylcyclohexa-2,5-dien-1-one using methylene blue as photosensitizer in a solvent mixture of water and alcohols using light of the high wavelength range of the visible spectrum. This process allows 5 obtaining 4-hydroxy-2,4,6-trimethylcyclohexa-2,5-dien-1-one and 2,3,5-trimethyl-hydroquinone in high yields and selectivity from 2,4,6-trimethylphenol.

公开(公告)号：US20210130314A1

公开(公告)日：2021-05-06

申请号：US17041910

申请日：2019-03-29

申请人： DSM IP ASSETS B.V.

发明人： Laure CLASADONTE ,  André DUESTERLOH ,  Weerasinghe INDRASENA ,  Thomas NETSCHER ,  René STEMMLER

IPC分类号： C07D311/72

摘要： The present invention is directed towards the use of substituted chroman-6-ols with extended lipophilic side chains of formula (I) wherein one of the two substituents R1 and R2 is C12-21-alkyl and the other of the two substituents R1 and R2 is either hydrogen or C1-5-alkyl or (CH2)n—OH with n being an integer from 1 to 5, and wherein A is CH(R3), and wherein R3, R4 and R6 are independently from each other H or C1-4-alkyl, and wherein R5 is H or OH or C1-4-alkyl or C1-4-alkoxy; with the proviso that at least two of R4, R5 and R6 are not methyl, when R3 is H and one of the substituents R1 and R2 is methyl and the other of the two substituents R1 and R2 is C12-21-alkyl, as antioxidants, especially in feed such as pet food and feed ingredients such as fish meal, insect meal and poultry meal, as well as PUFA-containing oil such as marine oil, microbial oil, fungal oil, algal oil and PUFA-containing plant oil. The present invention is further directed towards feed ingredients and feed for insects, aquatic and terrestrial animals comprising such substituted chroman-6-ols with extended lipophilic side chains of formula (I).

公开(公告)号：US20160185702A1

公开(公告)日：2016-06-30

申请号：US14652362

申请日：2013-12-18

申请人： DSM IP ASSETS B.V.

发明人： Werner BONRATH ,  Thomas NETSCHER ,  Jonathan Alan MEDLOCK ,  René Tobias STEMMLER ,  Gerardus Karel Maria VERZIJL ,  Andreas Hendrikus Maria DE VRIES

IPC分类号： C07C45/67 ,  C07C45/62

CPC分类号： C07C45/67 ,  C07B2200/07 ,  C07C45/62 ,  C07C49/04 ,  C07C47/02

摘要： The present invention relates to a process of manufacturing compound having stereogenic centres from a mixture of E/Z isomers of unsaturated compounds having prochiral double bonds. The hydrogenation product has a specific desired configuration at the stereogenic centres. The process involves an asymmetric hydrogenation and an isomerization step. The process is very advantageous in that it forms the desired chiral product from a mixture of stereoisomers of the starting product in an efficient way.

摘要翻译： 本发明涉及由具有前手性双键的不饱和化合物的E / Z异构体的混合物制造具有立体中心化合物的方法。 氢化产物在立体中心处具有特定的所需构型。 该方法包括不对称氢化和异构化步骤。 该方法非常有利，因为它以有效的方式从起始产物的立体异构体的混合物形成所需的手性产物。

公开(公告)号：US20160168111A1

公开(公告)日：2016-06-16

申请号：US14902662

申请日：2014-07-03

申请人： DSM IP ASSETS B.V.

发明人： Ulla LETINOIS ,  Thomas NETSCHER

IPC分类号： C07D311/22

CPC分类号： C07D311/22 ,  C07B2200/09

摘要： The present invention relates to a synthesis of chromanones or chromanes in a stereospecific matter in view of the 2-position in the chromanone or chromane ring. It has been found that this synthesis is particularly possible in the presence of a chiral compound of formula of a specific type and of at least one phenol or thiophenol.

摘要翻译： 本发明涉及在苯并二氢吡喃酮或苯并二氢吡喃环中2-位的立体特异性物质中的色满酮或色烷的合成。 已经发现，在特定类型的式的手性化合物和至少一种苯酚或苯硫酚的存在下，该合成是特别有可能的。

公开(公告)号：US20210037855A1

公开(公告)日：2021-02-11

申请号：US17041757

申请日：2019-03-29

申请人： DSM IP ASSETS B.V.

发明人： Laure CLASADONTE ,  André DUESTERLOH ,  Weerasinghe INDRASENA ,  Thomas NETSCHER ,  René Tobias STEMMLER

IPC分类号： A23K20/121 ,  C07D493/08 ,  A23K10/22 ,  A23K20/158 ,  A23K20/174 ,  A23K20/111 ,  A23K50/30 ,  A23K50/40 ,  A23K50/75

摘要： The present invention is directed towards the use of at least one compound of formula (I) wherein R1, R2 and R3 are independently from each other H or linear C1-6-alkyl or branched C3-8-alkyl, as antioxidant, especially in feed such as pet food and feed ingredients such as fish meal, insect meal and poultry meal, as well as PUFA-containing oils such as marine oil, microbial oil, fungal oil, algal oil and PUFA-containing plant oil. The present invention is further directed towards feed ingredients and feed for insects, aquatic and terrestrial animals comprising such twin chromanols of formula (I).

公开(公告)号：US20180155311A1

公开(公告)日：2018-06-07

申请号：US15575994

申请日：2016-05-23

申请人： DSM IP ASSETS B.V.

发明人： Dominik BURGER ,  Thomas NETSCHER ,  Gerhard SCHIEFER

IPC分类号： C07D311/72 ,  B01D15/40 ,  B01D15/38 ,  A23K20/10 ,  A23L33/10

CPC分类号： C07D311/72 ,  A23K20/10 ,  A23L33/10 ,  A23V2002/00 ,  B01D15/3833 ,  B01D15/40 ,  C07B57/00 ,  Y02P20/544

摘要： The present invention relates to the field of separating chiral isomers from each other. Particularly, it relates to the field of separating of chiral isomers of chromane or chromene compounds, particularly tocopherols, 3,4-dehydro-tocopherols and tocotrienols, as well as the protected forms thereof. It has been found that the use of supercritical carbon dioxide as mobile phase combined with the very specific chiral phase as stationary phase leads to a very efficient separation of the individual chiral isomers. As the method is very efficient and fast combined with advantageous in view of ecology it is of big industrial interest.

公开(公告)号：US20170349563A1

公开(公告)日：2017-12-07

申请号：US15535477

申请日：2015-12-09

申请人： DSM IP ASSETS B.V.

发明人： Ulla LETINOIS ,  Thomas NETSCHER

IPC分类号： C07D311/04 ,  C07C37/14 ,  C07C1/32 ,  C07C37/00 ,  C07F7/08 ,  C07C45/00

CPC分类号： C07D311/04 ,  C07C1/321 ,  C07C37/00 ,  C07C37/14 ,  C07C45/00 ,  C07F7/0805 ,  C07C39/19

摘要： The present invention relates to a method of preparing chromanes from 2,5-dimethylfuran and substituted alkynes comprising an long chain unsaturated alkyl group as substituent in the alpha position of a substituted phenol followed by oxidation, reduction and acid ring closure. It is particularly advantageous to use 2,5-dimethylfuran as this offers an ecological beneficial synthesis of β-tocopherol.

公开(公告)号：US20170313654A1

公开(公告)日：2017-11-02

申请号：US15518097

申请日：2015-10-15

申请人： DSM IP ASSETS B.V.

发明人： Werner BONRATH ,  Jan SCHUETZ ,  Thomas NETSCHER ,  Bettina WUESTENBERG

IPC分类号： C07C403/14 ,  C07C47/225 ,  C07C45/51 ,  C07C47/21 ,  C07C13/20 ,  C07C2601/16

CPC分类号： C07C403/14 ,  C07C13/20 ,  C07C45/512 ,  C07C47/21 ,  C07C47/225 ,  C07C403/08 ,  C07C2523/00 ,  C07C2601/16

摘要： The present invention relates to a new method to produce 7,8-dihydro-C15-aldehyde.