公开(公告)号：US20210052509A1

公开(公告)日：2021-02-25

申请号：US17088700

申请日：2020-11-04

Applicant: DSM IP ASSETS B.V.

Inventor： George MIHOV ,  Guy DRAAISMA ,  Silvana Rensina Antonnietta DI SILVESTRE ,  Tristan HANDELS

IPC: A61K9/70 ,  A61K47/34 ,  A61K31/5575 ,  A61K9/00 ,  C08G69/36 ,  C08G69/44 ,  C08L77/12 ,  A61F9/00 ,  A61F9/007

Abstract: The present invention relates to a drug delivery system comprising a core and a shell in which the core comprises a hydrolytically degradable polymer X which polymer backbone comprises pendant ester and acid functionalities and in which the shell comprises a hydrolytic degradable polymer Y. The hydrolytic degradable polymers X and Y are different polymers. Polymer X further comprises amino-acids in the polymer backbone and degrades via zero order degradation kinetics for a period of at least 3 months. Polymer Y degrades via auto-acceleration degradation kinetics.

公开(公告)号：US20200038337A1

公开(公告)日：2020-02-06

申请号：US16549127

申请日：2019-08-23

Applicant: DSM IP Assets, B.V.

Inventor： George MIHOV ,  Guy DRAAISMA ,  Silvana Rensina Antonnietta DI SILVESTRE ,  Tristan HANDELS

IPC: A61K9/70 ,  A61K47/34 ,  A61K31/5575 ,  A61F9/00 ,  A61F9/007 ,  A61K9/00 ,  C08G69/36 ,  C08G69/44 ,  C08L77/12

Abstract: The present invention relates to a drug delivery system comprising a core and a shell in which the core comprises a hydrolytically degradable polymer X which polymer backbone comprises pendant ester and acid functionalities and in which the shell comprises a hydrolytic degradable polymer Y. The hydrolytic degradable polymers X and Y are different polymers. Polymer X further comprises amino-acids in the polymer backbone and degrades via zero order degradation kinetics for a period of at least 3 months. Polymer Y degrades via auto-acceleration degradation kinetics.

公开(公告)号：US20170367992A1

公开(公告)日：2017-12-28

申请号：US15534499

申请日：2015-12-18

Applicant: DSM IP ASSETS B.V.

Inventor： George MIHOV ,  Guy DRAAISMA ,  Silvana Rensina Antonnietta DI SILVESTRE ,  Tristan HANDELS

IPC: A61K9/70 ,  A61K47/34 ,  A61F9/007 ,  A61F9/00 ,  A61K31/5575 ,  A61F9/008

CPC classification number: A61K9/70 ,  A61F9/0008 ,  A61F9/0017 ,  A61F9/00781 ,  A61F2009/00872 ,  A61F2009/00891 ,  A61K9/0051 ,  A61K31/5575 ,  A61K47/34 ,  C08G69/36 ,  C08G69/44 ,  C08L77/12

Abstract: The present invention relates to a drug delivery system comprising a core and a shell in which the core comprises a hydrolytically degradable polymer X which polymer backbone comprises pendant ester and acid functionalities and in which the shell comprises a hydrolytic degradable polymer Y. The hydrolytic degradable polymers X and Y are different polymers. Polymer X further comprises amino-acids in the polymer backbone and degrades via zero order degradation kinetics for a period of at least 3 months. Polymer Y degrades via auto-acceleration degradation kinetics.