中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

6 records (took 0.018 seconds)

    BIODEGRADABLE POLYESTERAMIDE COPOLYMERS FOR DRUG DELIVERY
    1.
    发明申请
    BIODEGRADABLE POLYESTERAMIDE COPOLYMERS FOR DRUG DELIVERY 有权
    用于药物递送的生物可降解的聚酰胺酰胺共聚物

    公开(公告)号：US20170051110A1

    公开(公告)日：2017-02-23

    申请号：US15252350

    申请日：2016-08-31

    Applicant: DSM IP ASSETS B.V.

    Inventor： Guy DRAAISMA ,  George MIHOV

    IPC: C08G69/44 ,  C08L77/12 ,  A61K31/165 ,  C09D177/12 ,  A61K47/34 ,  A61K9/70

    CPC classification number: C08G69/44 ,  A61K9/0048 ,  A61K9/7007 ,  A61K31/165 ,  A61K47/34 ,  C08L77/12 ,  C08L2203/16 ,  C09D177/12

    Abstract: The present invention relates to a poly (ester amide) (PEA) having a chemical formula described by structural formula (IV), wherein m+p varies from 0.9-0.1 and q varies from 0.1 to 0.9 m+p+q=1 whereby m or p could be 0 n is about 5 to about 300; (pref. 50-200) R1 is independently selected from the group consisting of (C2-C20) alkylene, (C2-C20) alkenylene, —(R9—CO—O—R10—O—CO—R9)—, —CHR11—O—CO—R12—COOCR11— and combinations thereof; R3 and R4 in a single backbone unit m or p, respectively, are independently selected from the group consisting of hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C6-C10)aryl, (C1-C6)alkyl, —(CH2)SH, —(CH2)2S(CH3), —CH2OH, —CH(OH)CH3, —(CH2)4NH3+, —(CH2)3NHC(═NH2+)NH2, —CH2COOH, —(CH2)COOH, —CH2—CO—NH2, —CH2CH2—CO—NH2, —CH2CH2COOH, CH3—CH2—CH(CH3)—, (CH3)2—CH—CH2—, H2N—(CH2)4—, Ph-CH2—, CH═C—CH2—, HO-p-Ph-CH2—, (CH3)2—CH—, Ph-NH—, NH—(CH2)3—C—, NH—CH═N—CH═C—CH2—. R5 is selected from the group consisting of (C2-C20)alkylene, (C2-C20)alkenylene, alkyloxy or oligoethyleneglycol R6 is selected from bicyclic-fragments of 1,4:3,6-dianhydrohexitols of structural formula (III); R7 is selected from the group consisting of (C6-C10)aryl (C1-C6)alkyl R8 is —(CH2)4-; R9 or R10 are independently selected from C2-C12 alkylene or C2-C12 alkenylene. R11 or R12 are independently selected from H, methyl, C2-C12 alkylene or C2-C12 alkenylene whereby a is at least 0.05 and b is at least 0.05 and a+b=1.

    BIODEGRADABLE POLYESTERAMIDE COPOLYMERS FOR DRUG DELIVERY
    6.
    发明申请
    BIODEGRADABLE POLYESTERAMIDE COPOLYMERS FOR DRUG DELIVERY 有权

    公开(公告)号：US20160367681A1

    公开(公告)日：2016-12-22

    申请号：US15252321

    申请日：2016-08-31

    Applicant: DSM IP ASSETS B.V.

    Inventor： Guy DRAAISMA ,  George MIHOV

    IPC: A61K47/34 ,  A61K31/165

    CPC classification number: C08G69/44 ,  A61K31/165 ,  A61K47/34 ,  A61K47/6921 ,  C08J5/18 ,  C08J2377/12 ,  C08L77/12 ,  Y10T428/2982

    Abstract: The present invention relates to a poly (ester amide) (PEA) having a chemical formula described by structural formula (IV), wherein m+p varies from 0.9-0.1 and q varies from 0.1 to 0.9 m+p+q=1 whereby m or p could be 0 n is about 5 to about 300; (pref. 50-200) R1 is independently selected from the group consisting of (C2-C20 alkylene, (C2-C20) alkenylene, —(R9—CO—O—R10—O—CO—R9)—, -CHR11-O-CO-R12—COOCR11— and combinations thereof; R3 and R4 in a single backbone unit m or p, respectively, are independently selected from the group consisting of hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C6-C10)aryl, (C1-C6)alkyl, —(CH2)SH, —(CH2)S(CH 3), —CH2OH, —CH(OH)CH3, —(CH2)4NH3+, —(CH2)3NHC(═NH2+)NH2, —CH2COOH, —(CH2)COOH, —CH2—CO—NH2, —CH2CH2—CO—NH2, —CH2CH2COOH, CH3—CH2—CH(CH3)—, (CH3)2—CH—CH2—, H2N—(CH2)4—, Ph-CH2—, CH═C—CH2—, HO-p-Ph-CH2—, (CH3)2—CH—, Ph-NH—, NH—(CH2)3—C—, NH—CH═N—CH═C—CH2—. R5 is selected from the group consisting of (C2-C20)alkylene, (C2-C20)alkenylene, alkyloxy or oligoethyleneglycol R6 is selected from bicyclic-fragments of 1,4:3,6-dianhydrohexitols of structural formula (III); R7 is selected from the group consisting of (C6-C10)aryl (C1-C6)alkyl R8 is —(CH2)4—; R9 or R10 are independently selected from C2-C12 alkylene or C2-C12 alkenylene. R11 or R12 are independently selected from H, methyl, C2-C12 alkylene or C2-C12 alkenylene whereby a is at least 0.05 and b is at least 0.05 and a+b=1.

Patent Agency Ranking