公开(公告)号：US20190144838A1

公开(公告)日：2019-05-16

申请号：US16300212

申请日：2017-05-11

Applicant: DSM IP Assets B.V.

Inventor： Anne-Cecile V. BAYNE ,  Ross E. ZIRKLE

IPC: C12N9/10 ,  C12N15/82

Abstract: The subject disclosure features, in one aspect, a method for producing lipids enriched for EPA, comprising modifying a microalga to increase expression of PFA1, and/or PFA3, and culturing the modified microalga under conditions which allow the expression of PFA1, and/or PFA3, wherein lipids enriched for EPA are produced. Also featured is a recombinant microalga in which PFA1, and/or PFA3, is overexpressed. Such recombinant microalgae have been demonstrated herein to produce very favorable fatty acid lipid profiles (e.g., increased levels of EPA, increased ratio of EPA:DHA, decreased levels of DPA n-6, etc.).