公开(公告)号：US20160333058A1

公开(公告)日：2016-11-17

申请号：US15112911

申请日：2015-01-29

Applicant: Jessica Leigh MC GRATH ,  Bastien CHEVREUX ,  Peter Scott YORGEY ,  DSM IP ASSETS B.V.

Inventor： Jessica Leigh MC GRATH ,  Bastien CHEVREUX ,  Peter Scott YORGEY

IPC: C07K14/39 ,  C12N15/81 ,  C12P23/00

Abstract: The present invention relates to the use of novel promoters for heterologous gene expression, preferably for expression of genes in organisms of the genus Yarrowia, to the genetically modified organisms of the genus Yarrowia, and to a process for producing biosynthetic products by cultivating the genetically modified organisms.

Abstract translation: 本发明涉及用于异源基因表达的新型启动子，优选用于在耶氏酵母属的生物体中表达基因到耶氏酵母属的转基因生物的用途，以及通过培养经遗传修饰的生物合成产物的方法 生物体。

公开(公告)号：US20180171310A1

公开(公告)日：2018-06-21

申请号：US15579751

申请日：2016-06-06

Applicant: DSM IP Assets B.V.

Inventor： James G. METZ ,  Jun WANG ,  Bastien CHEVREUX ,  Ross E. ZIRKLE ,  Anne-Cecile BAYNE ,  James Casey LIPPMEIER

IPC: C12N9/10 ,  C12P7/64 ,  C12N15/82 ,  A23L33/115 ,  A23K20/158

Abstract: This disclosure concerns a novel modular docosahexaenoic acid (DHA) synthase and recombinant host organisms genetically modified with such synthase and one or more accessory proteins that allow for and/or improve the production of PUFAs in the host organism. The disclosure also concerns methods of making and using such organisms as well as products obtained from such organisms.

公开(公告)号：US20150315550A1

公开(公告)日：2015-11-05

申请号：US14650297

申请日：2013-08-27

Applicant: DSM IP ASSETS B.V.

Inventor： Christopher FARRELL ,  Maria MAYORGA ,  Bastien CHEVREUX

IPC: C12N9/02 ,  C12P23/00

CPC classification number: C12N9/0073 ,  C12P23/00 ,  C12Y114/13129

Abstract: The present invention relates to novel hydroxylases, nucleic acid sequences coding therefore, expression constructs and vectors comprising these sequences, microorganisms transformed therewith, processes for the microbiological hydroxylation of isoprenoids, for example processes for converting beta-carotene into beta-cryptoxanthin and zeaxanthin, or canthaxanthin into astaxanthin.

Abstract translation: 本发明涉及新的羟化酶，因此编码的核酸序列，表达构建体和包含这些序列的载体，转化的微生物，类异戊二烯的微生物羟基化的方法，例如将β-胡萝卜素转化成β-隐黄质和玉米黄质的方法，或 角黄素进入虾青素。