公开(公告)号：US20250160692A1

公开(公告)日：2025-05-22

申请号：US18839913

申请日：2023-02-24

Applicant: DSM IP Assets B.V.

Inventor： Aylvin Jorge Angelo Athanasius DIAS ,  Inge Jeannette MINTEN ,  Meredith Elsa WISEMAN

IPC: A61B5/145 ,  A61B5/1486 ,  C08G69/44

Abstract: Polyesteramide (PEA) copolymers are disclosed, having structures that include repeating units that contain various monomer residues characterized herein and present in the repeating units at defined ranges of molar equivalents. These copolymers can possess a number of important advantages for providing longer performing glucose sensors and/or for simplifying their design. For example, in vivo modeling has confirmed that these polymers exhibit both decreased collagen deposition and increased neovascularization (angiogenesis). Additional testing has demonstrated favorable oxygen and glucose transport capabilities, as well as other relevant properties.

公开(公告)号：US20250065011A1

公开(公告)日：2025-02-27

申请号：US18723269

申请日：2022-12-21

Applicant: DSM IP ASSETS B.V.

Inventor： Diego LÓPEZ BARREIRO ,  Jens Christoph THIES ,  Timothy A RINGEISEN ,  Inge Jeannette MINTEN

IPC: A61L27/22 ,  A61L27/46 ,  A61L27/56 ,  C07K14/78

Abstract: Synthetic biopolymers are disclosed, which can be engineered in terms of both their amino acid sequences and post-synthesis treatments to which they are subjected, to achieve desired gelation characteristics, particularly upon being exposed to physiological temperature (e.g., 37° C.). These synthetic biopolymers are therefore useful for injectable or implantable compositions for tissue repair, such as for bone void filler compositions. Examples of synthetic biopolymers are synthetic elastin-like polypeptides (ELPs) having polypeptide sequences with functional oligopeptide blocks that may include one or more hydrophobic blocks, one or more aggregation-enhancing blocks, and one or more β-sheet formation-inducing blocks. Optionally, one or more biomineralizing blocks may be present, to promote bone repair, growth, and/or strengthening.