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    FIBERS COMPRISING POLYESTERAMIDE COPOLYMERS FOR DRUG DELIVERY
    2.
    发明申请
    FIBERS COMPRISING POLYESTERAMIDE COPOLYMERS FOR DRUG DELIVERY 审中-公开

    公开(公告)号：US20200087819A1

    公开(公告)日：2020-03-19

    申请号：US16689569

    申请日：2019-11-20

    Applicant: DSM IP Assets B.V.

    Inventor： Mirian Hendrika Jacoba GILLISSEN-VAN DER VIGHT ,  Jens Christoph THIES ,  Gueorgui MIHOV

    IPC: D01F6/82 ,  C08G69/44 ,  A61K9/70 ,  C08L77/12 ,  A61K9/00 ,  A61K47/34

    Abstract: The present invention relates to fibers comprising a polyesteramide (PEA) having a chemical formula described by structural formula (iv), wherein −m+p varies from 0.9-0.1 and q varies from 0.1 to 0.9, −m+p+q=1 whereby m or p could be 0, −n is about 5 to about 300; (pref. 50-200), -Ri in independently selected from the group consisting of (C2-C20) alkykene or (C2-C20) alkenylene and combinations thereof; —R and R in a single backbone unit m or p, respectively, are independently selected from the group consisting of hydrogen, ()alkyl, ()alkenyl, (C-C)alkynyl, (C-Cio)aryl, —(CH2)SH, —(CH2)2S(CH), —CH2OH, —CH(OH)CH, —(CH2)NH3, —(CH2)NHC(—NH2—)NH2, —CH2COOH, —(CH2)COOH, —CH2—CO—NH2, —CH2CH2—CO—NH2, —CH2CH2COOH, CH—CH2—CH(CH), (CH)2—CH—CH2—, H2N—(CH2), Ph-CH2—, CH—C—CH2—, HO-p-Ph-CH2—, (CH)2—CH—, Ph-NH—, NH—(CH2)3—C—, NH—CH═N—CH═C—CH2—; —R5 is selected from the group consisting of (C2-C20)alkylene, (C2-C20)alkenylene, alkyloxy or oligoethyleneglycol, —R is selected from bicyclic-fragments of 1,4,3,6-dianhydrohexitols of structural formula (III); —R is selected from the group consisting of (C6-Cio)aryl, (GCeJalkyl, —R is —(CH2)4—; whereby a is at least 0.05 and b is at least 0.05 and a+b−.

    SYNTHETIC BIOPOLYMERS AND THEIR USE IN COMPOSITIONS FOR TISSUE REPAIR
    4.
    发明申请
    SYNTHETIC BIOPOLYMERS AND THEIR USE IN COMPOSITIONS FOR TISSUE REPAIR 有权

    公开(公告)号：US20250065011A1

    公开(公告)日：2025-02-27

    申请号：US18723269

    申请日：2022-12-21

    Applicant: DSM IP ASSETS B.V.

    Inventor： Diego LÓPEZ BARREIRO ,  Jens Christoph THIES ,  Timothy A RINGEISEN ,  Inge Jeannette MINTEN

    IPC: A61L27/22 ,  A61L27/46 ,  A61L27/56 ,  C07K14/78

    Abstract: Synthetic biopolymers are disclosed, which can be engineered in terms of both their amino acid sequences and post-synthesis treatments to which they are subjected, to achieve desired gelation characteristics, particularly upon being exposed to physiological temperature (e.g., 37° C.). These synthetic biopolymers are therefore useful for injectable or implantable compositions for tissue repair, such as for bone void filler compositions. Examples of synthetic biopolymers are synthetic elastin-like polypeptides (ELPs) having polypeptide sequences with functional oligopeptide blocks that may include one or more hydrophobic blocks, one or more aggregation-enhancing blocks, and one or more β-sheet formation-inducing blocks. Optionally, one or more biomineralizing blocks may be present, to promote bone repair, growth, and/or strengthening.

    Method of making an osteoconductive polymer article and an osteoconductive polymer article thus made
    6.
    发明申请
    Method of making an osteoconductive polymer article and an osteoconductive polymer article thus made 审中-公开

    公开(公告)号：US20200316259A1

    公开(公告)日：2020-10-08

    申请号：US16753351

    申请日：2018-10-05

    Applicant: DSM IP Assets B.V. ,  ACADEMISCH ZIEKENHUIS MAASTRICHT

    Inventor： Jens Christoph THIES ,  Ruud Jozef Regina Wilhelmus PETERS ,  Pieter J. EMANS ,  Jacob KOENEN

    IPC: A61L27/46 ,  A61L27/44 ,  A61L27/56 ,  A61L27/54

    Abstract: The disclosure relates to methods of making an osteoconductive polymer article for use as an orthopedic implant comprises steps of forming an article from a biocompatible, non-biodegradable polymer, the article comprising a non-flat surface with roughness Ra of at least 5 μm; providing a dispersion of bioactive ceramic particles of particle size at most 10 μm in a first solvent comprising a solvent for the polymer; coating at least the non-flat surface with the dispersion in at least one step; and rinsing the coated article with a second solvent being a non-solvent for the polymer to substantially remove the first solvent. Further disclosed is an osteoconductive polymer article for use as an orthopedic implant, which article is made from a biocompatible, non-biodegradable polymer and comprises a non-flat surface with roughness Ra of at least 5 μm, wherein bioactive ceramic particles of particle size at most 10 μm are partly embedded in the polymer at the surface of the article. The methods exhibit benefits in ease of modifying a surface layer with bioactive particles, applying mild conditions and not requiring use of further additives or post-treatments, or without significantly affecting bulk polymer properties, and result in an orthopedic implant article having particles adhering to the surface while still being accessible for interaction with surrounding tissue or fluid.

    FIBERS COMPRISING POLYESTERAMIDE COPOLYMERS FOR DRUG DELIVER
    10.
    发明申请
    FIBERS COMPRISING POLYESTERAMIDE COPOLYMERS FOR DRUG DELIVER 有权

    公开(公告)号：US20220002912A1

    公开(公告)日：2022-01-06

    申请号：US17381320

    申请日：2021-07-21

    Applicant: DSM IP Assets B.V.

    Inventor： Mirian Hendrika Jacoba GILLISEN-VAN DER VIGHT ,  Jens Christoph THIES ,  Gueorgui MIHOV

    IPC: D01F6/82 ,  A61K9/00 ,  C08G69/44 ,  A61K47/34 ,  A61K9/70 ,  C08L77/12

    Abstract: The present invention relates to fibers comprising a polyesteramide (PEA) having a chemical formula described by structural formula (IV), wherein m+p varies from 0.9-0.1 and q varies from 0.1 to 0.9; m+p+q=1 whereby m or p could be 0; n is about 5 to about 300; (pref. 50-200); R1 is independently selected from the group consisting of (C2-C20) alkylene, (C2-C20) alkenylene, —(R9—CO—O—R10—O—CO—R9)—, —CHR11—O—CO—R12—COOCR11—, and combinations thereof; R3 and R4 in a single backbone unit m or p, respectively, are independently selected from the group consisting of hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C6-C10)aryl, (C1-C6)alkyl, —(CH2)SH, —(CH2)2S(CH3), —CH2OH, —CH(OH)CH3, —(CH2)4NH3+, —(CH2)3NHC(═NH2+)NH2, —CH2COOH, —(CH2)COOH, —CH2—CO—NH2, —CH2CH2—CO—NH2, —CH2H2COOH, CH3—CH2—CH(CH3)—, (CH3)2—CH—CH2—, H2N—(CH2)4—, Ph-CH2—, CH═C—CH2—, HO-p-Ph-CH2—, (CH3)2—CH—, Ph-NH—, NH—(CH2)3—C—, NH—CH═N—CH═C—CH2—; R5 is selected from the group consisting of (C2-C20)alkylene, (C2-C20)alkenylene, alkyloxy or oligoethyleneglycol; R6 is selected from bicyclic-fragments of 1,4:3,6-dianhydrohexitols of structural formula (III); R7 is selected from the group consisting of (C6-C10)aryl(C1-C6)alkyl; R8 is —(CH2)4-; R9 or R10 are independently selected from C2-C12 alkylene or C2-C12 alkenylene; and R11 or R12 are independently selected from H, methyl, C2-C12 alkylene or C2-C12 alkenylene whereby a is at least 0.05 and b is at least 0.05 and a+b=1.

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