公开(公告)号：US20240374624A1

公开(公告)日：2024-11-14

申请号：US18685028

申请日：2022-08-23

Applicant: DSM IP ASSETS B.V.

Inventor： Remo CAMPICHE ,  Riccardo SFRISO

IPC: A61K31/702 ,  A61P17/10

Abstract: The present invention relates to compositions comprising at least one human milkoligosaccharide selected from the group consisting of 2′-fucosyllactose, difucosyllactose and/or lacto-N-tetraose as an anti-microbial agent against Cutibacterium acnes (C. acnes) as well as the use thereof in a regimen to prevent and/or treat acne comprising the steps of topically administering a composition comprising said human milk oligosaccharide(s) to the skin of a subject with acne/acne prone skin followed by topically administering a composition comprising one or more non-pathogenic live bacterial C. acnes strains.

公开(公告)号：US20230346686A1

公开(公告)日：2023-11-02

申请号：US18026681

申请日：2021-09-17

Applicant: DSM IP ASSETS B.V.

Inventor： Joshua CLAYPOOL ,  Dominik IMFELD ,  Riccardo SFRISO

IPC: A61K8/9789 ,  A61Q17/00

CPC classification number: A61K8/9789 ,  A61Q17/00

Abstract: The present invention relates to an Epilobium extract, preferably an Epilobium fleischeri extract for use as a prebiotic.

公开(公告)号：US20230368914A1

公开(公告)日：2023-11-16

申请号：US18022361

申请日：2021-08-24

Applicant: DSM IP ASSETS B.V.

Inventor： Kevin FREEMAN ,  Joshua CLAYPOOL ,  Ghislain SCHYNS ,  Riccardo SFRISO

IPC: G16H50/20 ,  G16H50/30 ,  G16H20/60 ,  A61B5/00

CPC classification number: G16H50/20 ,  G16H50/30 ,  G16H20/60 ,  A61B5/4866

Abstract: In some aspects, the disclosure is directed to methods and systems for identifying a set of predictor metabolites which are predictive of a state of an animal subject. For that purpose, a plurality of data sets of respective ones of a plurality of animal subjects may be obtained, wherein each of the plurality of data sets comprises measurement data comprising an indication of a concentration of each of a plurality of metabolites in a sample of a microbiome of a respective animal subject. A label may be provided at least in part characterizing the state of the animal subject. A feature selection process may be applied to the plurality of data sets to select and thereby identify a subset of the plurality of metabolites of which subset the concentrations are a statistically significant predictor of the state according to the label.

公开(公告)号：US20230338265A1

公开(公告)日：2023-10-26

申请号：US18025380

申请日：2021-09-10

Applicant: DSM IP Assets B.V.

Inventor： Joshua CLAYPOOL ,  Riccardo SFRISO

IPC: A61K8/73 ,  A61Q17/00

CPC classification number: A61K8/73 ,  A61Q17/005

Abstract: The invention relates to a new use of saccharide isomerate for enriching the abundance of Paracoccus marcusii within the skin microbiome of an individual.