公开(公告)号：US20240368666A1

公开(公告)日：2024-11-07

申请号：US18291626

申请日：2022-07-26

Applicant: DSM IP Assets B.V.

Inventor： Willi GOTTSTEIN ,  Paul KLAASSEN ,  Paulus Petrus DE WAAL

IPC: C12Q1/06 ,  A23C9/123

Abstract: A method of determining a quantitative composition ratio of a microbial strain mixture for use in a fermentation process. The method includes repeatedly performing method cycles, each method cycle comprising the steps of: selecting a set of plurality of microbial strain mixtures having different quantitative composition ratios; concurrently performing fermentation processes for each selected microbial strain mixture; determining, for each of the fermentation processes, at least one performance indicator of the microbial strain mixture; and providing the at least one performance indicator for each of the fermentation processes to a statistical model which is configured to optimize a predefined objective function, wherein the statistical model is configured to determine, based on said determined performance indicators, a subsequent set of plurality of microbial strain mixtures with different quantitative composition ratios for selection in a next cycle.