公开(公告)号：US09873727B2

公开(公告)日：2018-01-23

申请号：US14444431

申请日：2014-07-28

Applicant: DUKE UNIVERSITY

Inventor： Bruce A. Sullenger ,  Shahid Nimjee ,  Sabah Oney ,  Nanette Que-Gewirth

IPC: C12N15/115 ,  C07K14/705 ,  C07H21/00 ,  C07H21/04 ,  A61K31/7088 ,  A61K31/711 ,  C12N15/113

CPC classification number: C07K14/70557 ,  A61K31/7088 ,  A61K31/711 ,  C07H21/00 ,  C07H21/04 ,  C12N15/113 ,  C12N15/115 ,  C12N2310/113 ,  C12N2310/16 ,  C12N2310/322 ,  C12N2310/3533

Abstract: The present invention relates, in general, to receptors and to platelet aggregation and, in particular, to a method of inhibiting platelet aggregation using an aptamer that binds to and inhibits the activity of a receptor, such as glycoprotein IIb/IIIa (gpIIb/IIIa), and to aptamers suitable for use in such a method. The invention also relates to antidotes to antiplatelet agents and to methods of using such antidotes to reverse aptamer-induced platelet inhibition. The invention further relates to von Willebrand Factor (VWF) inhibitors, and antidotes therefore, and to methods of using same.

公开(公告)号：US20160289297A1

公开(公告)日：2016-10-06

申请号：US14444431

申请日：2014-07-28

Applicant: DUKE UNIVERSITY

Inventor： Bruce A. Sullenger ,  Shahid Nimjee ,  Sabah Oney ,  Nanette Que-Gewirth

IPC: C07K14/705

CPC classification number: C07K14/70557 ,  A61K31/7088 ,  A61K31/711 ,  C07H21/00 ,  C07H21/04 ,  C12N15/113 ,  C12N15/115 ,  C12N2310/113 ,  C12N2310/16 ,  C12N2310/322 ,  C12N2310/3533

Abstract: The present invention relates, in general, to receptors and to platelet aggregation and, in particular, to a method of inhibiting platelet aggregation using an aptamer that binds to and inhibits the activity of a receptor, such as glycoprotein IIb/IIIa (gpIIb/IIIa), and to aptamers suitable for use in such a method. The invention also relates to antidotes to antiplatelet agents and to methods of using such antidotes to reverse aptamer-induced platelet inhibition. The invention further relates to von Willebrand Factor (VWF) inhibitors, and antidotes therefore, and to methods of using same.

Abstract translation: 本发明一般涉及受体和血小板聚集，特别涉及使用结合并抑制受体（例如糖蛋白IIb / IIIa（gpIIb / IIIa））的活性的适体抑制血小板聚集的方法 ）以及适用于这种方法的适体。 本发明还涉及抗血小板剂的解毒剂以及使用这种解毒剂来逆转适体诱导的血小板抑制的方法。 本发明还涉及血管性血友病因子（VWF）抑制剂和解毒剂，以及其使用方法。