公开(公告)号：US09901553B2

公开(公告)日：2018-02-27

申请号：US15154539

申请日：2016-05-13

Applicant: DUKE UNIVERSITY

Inventor： Bruce A. Sullenger ,  Sabah Oney ,  Tung Suet Ruby Lam ,  Kam Leong

IPC: C12N15/11 ,  A61K31/164 ,  A61K31/00 ,  C07K14/46 ,  G01N33/53 ,  G01N33/94 ,  A61K31/132 ,  A61K31/14 ,  C12N15/115 ,  A61K38/00

CPC classification number: A61K31/164 ,  A61K31/00 ,  A61K31/132 ,  A61K31/14 ,  A61K38/00 ,  C07K14/46 ,  C12N15/111 ,  C12N15/115 ,  C12N2310/16 ,  C12N2320/50 ,  G01N33/5308 ,  G01N33/94 ,  G01N2500/00 ,  G01N2500/20

Abstract: The present invention relates, in general, to agents that modulate the pharmacological activity of nucleic acid molecules and, in particular, to agents that bind therapeutic or diagnostic nucleic acid molecules in a sequence independent manner and modulate (e.g., inhibit or reverse) their activity. The invention also relates to compositions comprising such agents and to methods of using same.

公开(公告)号：US20160250165A1

公开(公告)日：2016-09-01

申请号：US15154539

申请日：2016-05-13

Applicant: DUKE UNIVERSITY

Inventor： Bruce A. Sullenger ,  Sabah Oney ,  Tung Suet Ruby Lam ,  Kam Leong

IPC: A61K31/164 ,  C12N15/115 ,  G01N33/53 ,  A61K31/14 ,  A61K31/132

CPC classification number: A61K31/164 ,  A61K31/00 ,  A61K31/132 ,  A61K31/14 ,  A61K38/00 ,  C07K14/46 ,  C12N15/111 ,  C12N15/115 ,  C12N2310/16 ,  C12N2320/50 ,  G01N33/5308 ,  G01N33/94 ,  G01N2500/00 ,  G01N2500/20

Abstract: The present invention relates, in general, to agents that modulate the pharmacological activity of nucleic acid molecules and, in particular, to agents that bind therapeutic or diagnostic nucleic acid molecules in a sequence independent manner and modulate (e.g., inhibit or reverse) their activity. The invention also relates to compositions comprising such agents and to methods of using same.

Abstract translation: 本发明一般涉及调节核酸分子的药理学活性的试剂，特别是涉及以不依赖序列的方式结合治疗或诊断核酸分子并调节（例如抑制或逆转）其活性的试剂 。 本发明还涉及包含这些试剂的组合物及其使用方法。