公开(公告)号：US10988749B2

公开(公告)日：2021-04-27

申请号：US16078037

申请日：2017-02-22

Applicant: DA VOLTERRA ,  BIOASTER

Inventor： Jean De Gunzburg ,  Jean-Denis Docquier

IPC: C12N9/86 ,  A61K9/00 ,  A61K31/407 ,  A61K31/496 ,  A61K31/546 ,  A61K38/50

Abstract: The present invention relates to an isolated polypeptide having beta-lactamase activity and nucleic acid sequences encoding the polypeptide. The isolated polypeptide of the invention is a VIM-2 variant with improved properties such as improved protease stability.

公开(公告)号：US10982205B2

公开(公告)日：2021-04-20

申请号：US16078040

申请日：2017-02-22

Applicant: DA VOLTERRA ,  BIOASTER

Inventor： Jean De Gunzburg ,  Jean-Denis Docquier

IPC: C12N9/86 ,  A61K31/43 ,  A61K38/50 ,  A61K45/06 ,  A61K38/00

Abstract: The present invention relates to an isolated polypeptide having beta-lactamase activity and nucleic acid sequences encoding the polypeptide. The isolated polypeptide of the invention is a Verona integron-encoded metallo-β-lactamase (VIM-2) variant with improved properties such as improved protease stability, stability in intestinal medium, improved activity against one or more antibiotics, improved specific activity and/or improved production in a host cell.

公开(公告)号：US20200318094A1

公开(公告)日：2020-10-08

申请号：US16757968

申请日：2018-10-24

Applicant: Da Volterra ,  Bioaster

Inventor： Jean De Gunzburg ,  Jean-Denis Docquier

IPC: C12N9/86 ,  A61K38/50 ,  A61K31/407 ,  A61K31/496 ,  A61K31/546

Abstract: The present invention relates to an isolated polypeptide having beta-lactamase activity and nucleic acid sequences encoding the polypeptide. The isolated polypeptide of the invention is a VIM-2 variant with improved properties such as improved protease stability, stability in intestinal medium, improved activity against one or more antibiotics, improved specific activity and/or improved production in a host cell.

公开(公告)号：US20220356459A1

公开(公告)日：2022-11-10

申请号：US17745205

申请日：2022-05-16

Applicant: Da Volterra ,  Bioaster

Inventor： Jean De Gunzburg ,  Jean-Denis Docquier

IPC: C12N9/86 ,  A61K31/407 ,  A61K31/496 ,  A61K31/546 ,  A61K38/50

Abstract: The present invention relates to an isolated polypeptide having beta-lactamase activity and nucleic acid sequences encoding the polypeptide. The isolated polypeptide of the invention is a VIM-2 variant with improved properties such as improved protease stability, stability in intestinal medium, improved activity against one or more antibiotics, improved specific activity and/or improved production in a host cell.

公开(公告)号：US11365403B2

公开(公告)日：2022-06-21

申请号：US16757968

申请日：2018-10-24

Applicant: Da Volterra ,  Bioaster

Inventor： Jean De Gunzburg ,  Jean-Denis Docquier

IPC: C12N9/84 ,  C12N1/21 ,  A61K38/50 ,  C12N9/86 ,  A61K31/407 ,  A61K31/496 ,  A61K31/546 ,  A61K38/00

Abstract: The present invention relates to an isolated polypeptide having beta-lactamase activity and nucleic acid sequences encoding the polypeptide. The isolated polypeptide of the invention is a VIM-2 variant with improved properties such as improved protease stability, stability in intestinal medium, improved activity against one or more antibiotics, improved specific activity and/or improved production in a host cell.