公开(公告)号：US20220259146A1

公开(公告)日：2022-08-18

申请号：US17732804

申请日：2022-04-29

申请人： Daewoong Pharmaceutical Co., Ltd.

发明人： Jeong-Taek Shin ,  Jeong-Hyun Son ,  Seung Chul Lee

IPC分类号： C07D207/36

摘要： The present invention relates to a method for preparing intermediates of 4-methoxypyrrole derivatives. The preparation method according to the present invention has advantages that the production cost can be lowered by using inexpensive starting materials, a high-temperature reaction is not required as a whole, inexpensive and non-explosive reagents are used instead of (trimethylsilyl)diazomethane, and further an intermediate of 4-methoxypyrrole derivatives can be prepared as a whole at a high yield.

公开(公告)号：US20200181080A1

公开(公告)日：2020-06-11

申请号：US16608924

申请日：2018-06-21

申请人： Daewoong Pharmaceutical Co., Ltd.

发明人： Jeong-Taek Shin ,  Jeong-Hyun Son ,  Seung Chul Lee

IPC分类号： C07D207/36

摘要： The present invention relates to a method for preparing intermediates of 4-methoxypyrrole derivatives. The preparation method according to the present invention has advantages that the production cost can be lowered by using inexpensive starting materials, a high-temperature reaction is not required as a whole, inexpensive and non-explosive reagents are used instead of (trimethylsilyl)diazomethane, and further an intermediate of 4-methoxypyrrole derivatives can be prepared as a whole at a high yield.

公开(公告)号：US10100010B1

公开(公告)日：2018-10-16

申请号：US15520518

申请日：2016-04-27

申请人： Daewoong Pharmaceutical Co., Ltd.

发明人： Chun Ho Lee ,  Seung Chul Lee ,  Yeon Im Lee ,  Deok Ki Eom ,  Mi Ryeong Han ,  Eun Ji Koh

IPC分类号： C07D207/48 ,  A61P31/04 ,  A61P1/16

摘要： The present invention provides a 4-methoxy pyrrole derivative or a pharmaceutically acceptable salt thereof, a preparation method thereof, and a pharmaceutical composition containing the same. The 4-methoxy pyrrole derivatives or pharmaceutically acceptable salts thereof according to the present invention have not only excellent proton pump inhibitory activity, gastric damage-inhibiting activity and defensive factor-enhancing effects, but also excellent eradication activity against H. pylori. Therefore, the 4-methoxy pyrrole derivatives or pharmaceutically acceptable salts thereof can be effectively used for the prevention and treatment of gastrointestinal damage due to gastrointestinal tract ulcer, gastritis, reflux esophagitis or H. pylori. Moreover, the 4-methoxy pyrrole derivatives or pharmaceutically acceptable salts thereof, have inhibitory activities against GPCR and thus can be effectively used for the prevention and treatment of 5-HT receptor-mediated or muscarinic acetylcholine receptor-mediated diseases.

公开(公告)号：US11345660B2

公开(公告)日：2022-05-31

申请号：US16608924

申请日：2018-06-21

申请人： Daewoong Pharmaceutical Co., Ltd.

发明人： Jeong-Taek Shin ,  Jeong-Hyun Son ,  Seung Chul Lee

IPC分类号： C07D207/36

摘要： The present invention relates to a method for preparing intermediates of 4-methoxypyrrole derivatives. The preparation method according to the present invention has advantages that the production cost can be lowered by using inexpensive starting materials, a high-temperature reaction is not required as a whole, inexpensive and non-explosive reagents are used instead of (trimethylsilyl)diazomethane, and further an intermediate of 4-methoxypyrrole derivatives can be prepared as a whole at a high yield.