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公开(公告)号：US20220064155A1
公开(公告)日：2022-03-03
申请号：US17269325
申请日：2019-08-27
发明人： Wol Young Kim , Yeon Im Lee , Youn Jung Yoon , Joon Seok Park , Deok Ki Eom , Keuk-Chan Bang , Jaehyun Jung
IPC分类号： C07D417/14 , C07D471/04 , C07D413/04
摘要： The present disclosure relates to a novel heterocyclic amine derivative represented by the following Chemical Formula 1 and a pharmaceutical composition comprising the same, and the compound according to the present disclosure can be usefully used for the prevention or treatment of autoimmune diseases or cancers. wherein, in Chemical Formula 1, R1, R2, X1, X2, L, Y, A and B are the same as defined in the specification.
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公开(公告)号：US10710961B2
公开(公告)日：2020-07-14
申请号：US16608910
申请日：2018-05-31
发明人： Jeong-Taek Shin , Jeong-Hyun Son , Deok Ki Eom , Chun Ho Lee
IPC分类号： C07D207/36
摘要： The present invention relates to a method for preparing intermediates of 4-methoxypyrrole derivatives. The preparation method according to the present invention has advantages that a high-temperature reaction is not required as a whole, inexpensive and non-explosive reagents are used instead of (trimethylsilyl)diazomethane, and further an intermediate of 4-methoxy pyrrole derivatives can be prepared as a whole at a high yield.
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公开(公告)号：US09676714B2
公开(公告)日：2017-06-13
申请号：US15026471
申请日：2014-10-02
发明人： Kyung A Yu , Ji Sung Yoon , Deok Ki Eom , Yeon Im Lee , Hye Ryun Shin , Jun Hee Lee , Ha Nee Seo , Ji Duck Kim , Sang Ho Lee , Chun Ho Lee
IPC分类号： C07D209/30 , C07D403/12 , C07D401/14 , C07D401/06 , C07D401/12 , C07D403/04 , C07D471/04 , C07D209/14 , C07D405/14
CPC分类号： C07D209/30 , C07D209/14 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/14 , C07D471/04
摘要： Disclosed are a sulfonylindole derivative useful for the prevention or treatment of peptic ulcer, gastritis or reflux esophagitis, a method of preparing the same, and a pharmaceutical composition containing the same.
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公开(公告)号：US11180496B2
公开(公告)日：2021-11-23
申请号：US16629392
申请日：2018-07-12
发明人： Keuk-Chan Bang , Deok Ki Eom , Joon Seok Park
IPC分类号： C07D471/04
摘要： The present invention relates to a novel 1H-pyrazolopyridine derivative and a pharmaceutical composition containing the same. The 1H-pyrazolopyridine derivative and the pharmaceutical composition containing the same can be usefully used for the prevention or treatment of autoimmune diseases or cancer.
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公开(公告)号：US10039747B2
公开(公告)日：2018-08-07
申请号：US14913696
申请日：2014-08-29
发明人： Kyung A Yu , Ji Sung Yoon , Deok Ki Eom , Yeon Im Lee , Mi Ryeong Han , Jun Hee Lee , Ha Nee Seo , Ji Duck Kim , Sang Ho Lee
IPC分类号： A61K31/4035 , A61K31/4439 , C07D209/44 , C07D209/52 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D471/04 , C07D487/04 , C07D405/10 , C07D409/12 , C07D409/14 , C07D405/04 , C07D405/12 , C07D409/04 , C07D498/04
摘要： The present invention provides tetrahydrocyclopentapyrrole derivatives that can be used for preventing or treating peptic ulcer, gastritis or reflux esophagitis, a method for preparing the same, and a pharmaceutical composition containing the same.
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公开(公告)号：US12110271B2
公开(公告)日：2024-10-08
申请号：US17273390
申请日：2019-09-19
发明人： Jeong-Taek Shin , Jeong-Hyun Son , Deok Ki Eom
IPC分类号： C07D207/48
CPC分类号： C07D207/48
摘要： The present disclosure relates to a manufacturing method for 4-methoxypyrrole derivatives. The embodiment of the present disclosure is useful for industrial mass production of 4-methoxypyrrole derivatives, because the process efficiency and yield are improved, and the use of hazardous reagents and environmental polluting reagents is avoided.
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公开(公告)号：US20230094404A1
公开(公告)日：2023-03-30
申请号：US17799774
申请日：2021-02-26
发明人： Wol Young Kim , Qing Ri Li , Deok Ki Eom , Hyae Jung Hyun , Joon Seok Park
IPC分类号： C07D417/14
摘要： The present disclosure relates to a method for preparing a heterocyclic amine derivative, and the preparation method according to the present disclosure has an advantage that a heterocyclic amine derivative having a reduced impurity content can be prepared in a high yield.
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公开(公告)号：US20210221770A1
公开(公告)日：2021-07-22
申请号：US17273390
申请日：2019-09-19
发明人： Jeong-Taek Shin , Jeong-Flyun Son , Deok Ki Eom
IPC分类号： C07D207/48
摘要： The present disclosure relates to a manufacturing method for 4-methoxypyrrole derivatives. The embodiment of the present disclosure is useful for industrial mass production of 4-methoxypyrrole derivatives, because the process efficiency and yield are improved, and the use of hazardous reagents and environmental polluting reagents is avoided.
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公开(公告)号：US20200181079A1
公开(公告)日：2020-06-11
申请号：US16608910
申请日：2018-05-31
发明人： Jeong-Taek Shin , Jeong-Hyun Son , Deok Ki Eom , Chun Ho Lee
IPC分类号： C07D207/36
摘要： The present invention relates to a method for preparing intermediates of 4-methoxypyrrole derivatives. The preparation method according to the present invention has advantages that a high-temperature reaction is not required as a whole, inexpensive and non-explosive reagents are used instead of (trimethylsilyl)diazomethane, and further an intermediate of 4-methoxy pyrrole derivatives can be prepared as a whole at a high yield.
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10.发明授权公开(公告)号：US10100010B1
公开(公告)日：2018-10-16
申请号：US15520518
申请日：2016-04-27
发明人： Chun Ho Lee , Seung Chul Lee , Yeon Im Lee , Deok Ki Eom , Mi Ryeong Han , Eun Ji Koh
IPC分类号： C07D207/48 , A61P31/04 , A61P1/16
摘要： The present invention provides a 4-methoxy pyrrole derivative or a pharmaceutically acceptable salt thereof, a preparation method thereof, and a pharmaceutical composition containing the same. The 4-methoxy pyrrole derivatives or pharmaceutically acceptable salts thereof according to the present invention have not only excellent proton pump inhibitory activity, gastric damage-inhibiting activity and defensive factor-enhancing effects, but also excellent eradication activity against H. pylori. Therefore, the 4-methoxy pyrrole derivatives or pharmaceutically acceptable salts thereof can be effectively used for the prevention and treatment of gastrointestinal damage due to gastrointestinal tract ulcer, gastritis, reflux esophagitis or H. pylori. Moreover, the 4-methoxy pyrrole derivatives or pharmaceutically acceptable salts thereof, have inhibitory activities against GPCR and thus can be effectively used for the prevention and treatment of 5-HT receptor-mediated or muscarinic acetylcholine receptor-mediated diseases.
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