公开(公告)号：US10710961B2

公开(公告)日：2020-07-14

申请号：US16608910

申请日：2018-05-31

Applicant: Daewoong Pharmaceutical Co., Ltd.

Inventor： Jeong-Taek Shin ,  Jeong-Hyun Son ,  Deok Ki Eom ,  Chun Ho Lee

IPC: C07D207/36

Abstract: The present invention relates to a method for preparing intermediates of 4-methoxypyrrole derivatives. The preparation method according to the present invention has advantages that a high-temperature reaction is not required as a whole, inexpensive and non-explosive reagents are used instead of (trimethylsilyl)diazomethane, and further an intermediate of 4-methoxy pyrrole derivatives can be prepared as a whole at a high yield.

公开(公告)号：US09676714B2

公开(公告)日：2017-06-13

申请号：US15026471

申请日：2014-10-02

Applicant: Daewoong Pharmaceutical Co., Ltd.

Inventor： Kyung A Yu ,  Ji Sung Yoon ,  Deok Ki Eom ,  Yeon Im Lee ,  Hye Ryun Shin ,  Jun Hee Lee ,  Ha Nee Seo ,  Ji Duck Kim ,  Sang Ho Lee ,  Chun Ho Lee

IPC: C07D209/30 ,  C07D403/12 ,  C07D401/14 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D471/04 ,  C07D209/14 ,  C07D405/14

CPC classification number: C07D209/30 ,  C07D209/14 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/14 ,  C07D471/04

Abstract: Disclosed are a sulfonylindole derivative useful for the prevention or treatment of peptic ulcer, gastritis or reflux esophagitis, a method of preparing the same, and a pharmaceutical composition containing the same.

公开(公告)号：US11180496B2

公开(公告)日：2021-11-23

申请号：US16629392

申请日：2018-07-12

Applicant: Daewoong Pharmaceutical Co., Ltd.

Inventor： Keuk-Chan Bang ,  Deok Ki Eom ,  Joon Seok Park

IPC: C07D471/04

Abstract: The present invention relates to a novel 1H-pyrazolopyridine derivative and a pharmaceutical composition containing the same. The 1H-pyrazolopyridine derivative and the pharmaceutical composition containing the same can be usefully used for the prevention or treatment of autoimmune diseases or cancer.

公开(公告)号：US10039747B2

公开(公告)日：2018-08-07

申请号：US14913696

申请日：2014-08-29

Applicant: Daewoong Pharmaceutical Co., Ltd.

Inventor： Kyung A Yu ,  Ji Sung Yoon ,  Deok Ki Eom ,  Yeon Im Lee ,  Mi Ryeong Han ,  Jun Hee Lee ,  Ha Nee Seo ,  Ji Duck Kim ,  Sang Ho Lee

IPC: A61K31/4035 ,  A61K31/4439 ,  C07D209/44 ,  C07D209/52 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D471/04 ,  C07D487/04 ,  C07D405/10 ,  C07D409/12 ,  C07D409/14 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  C07D498/04

Abstract: The present invention provides tetrahydrocyclopentapyrrole derivatives that can be used for preventing or treating peptic ulcer, gastritis or reflux esophagitis, a method for preparing the same, and a pharmaceutical composition containing the same.

公开(公告)号：US12227498B2

公开(公告)日：2025-02-18

申请号：US17269325

申请日：2019-08-27

Applicant: Daewoong Pharmaceutical Co., Ltd.

Inventor： Wol Young Kim ,  Yeon Im Lee ,  Youn Jung Yoon ,  Joon Seok Park ,  Deok Ki Eom ,  Keuk-Chan Bang ,  Jaehyun Jung

IPC: C07D417/14 ,  C07D413/04 ,  C07D471/04 ,  A61K31/4427 ,  A61K31/4523 ,  A61K31/496 ,  A61K31/506 ,  A61P35/00 ,  A61P37/00 ,  C07D401/14 ,  C07D403/14 ,  C07D417/12 ,  C07D487/04

Abstract: The present disclosure relates to a novel heterocyclic amine derivative represented by the following Chemical Formula 1 and a pharmaceutical composition comprising the same, and the compound according to the present disclosure can be usefully used for the prevention or treatment of autoimmune diseases or cancers. wherein, in Chemical Formula 1, R1, R2, X1, X2, L, Y, A and B are the same as defined in the specification.

公开(公告)号：US20220064155A1

公开(公告)日：2022-03-03

申请号：US17269325

申请日：2019-08-27

Applicant: Daewoong Pharmaceutical Co., Ltd.

Inventor： Wol Young Kim ,  Yeon Im Lee ,  Youn Jung Yoon ,  Joon Seok Park ,  Deok Ki Eom ,  Keuk-Chan Bang ,  Jaehyun Jung

IPC: C07D417/14 ,  C07D471/04 ,  C07D413/04

Abstract: The present disclosure relates to a novel heterocyclic amine derivative represented by the following Chemical Formula 1 and a pharmaceutical composition comprising the same, and the compound according to the present disclosure can be usefully used for the prevention or treatment of autoimmune diseases or cancers. wherein, in Chemical Formula 1, R1, R2, X1, X2, L, Y, A and B are the same as defined in the specification.

公开(公告)号：US12110271B2

公开(公告)日：2024-10-08

申请号：US17273390

申请日：2019-09-19

Applicant: Daewoong Pharmaceutical Co., Ltd.

Inventor： Jeong-Taek Shin ,  Jeong-Hyun Son ,  Deok Ki Eom

IPC: C07D207/48

CPC classification number: C07D207/48

Abstract: The present disclosure relates to a manufacturing method for 4-methoxypyrrole derivatives. The embodiment of the present disclosure is useful for industrial mass production of 4-methoxypyrrole derivatives, because the process efficiency and yield are improved, and the use of hazardous reagents and environmental polluting reagents is avoided.

公开(公告)号：US20230094404A1

公开(公告)日：2023-03-30

申请号：US17799774

申请日：2021-02-26

Applicant: Daewoong Pharmaceutical Co., Ltd.

Inventor： Wol Young Kim ,  Qing Ri Li ,  Deok Ki Eom ,  Hyae Jung Hyun ,  Joon Seok Park

IPC: C07D417/14

Abstract: The present disclosure relates to a method for preparing a heterocyclic amine derivative, and the preparation method according to the present disclosure has an advantage that a heterocyclic amine derivative having a reduced impurity content can be prepared in a high yield.

公开(公告)号：US20210221770A1

公开(公告)日：2021-07-22

申请号：US17273390

申请日：2019-09-19

Applicant: Daewoong Pharmaceutical Co., Ltd.

Inventor： Jeong-Taek Shin ,  Jeong-Flyun Son ,  Deok Ki Eom

IPC: C07D207/48

Abstract: The present disclosure relates to a manufacturing method for 4-methoxypyrrole derivatives. The embodiment of the present disclosure is useful for industrial mass production of 4-methoxypyrrole derivatives, because the process efficiency and yield are improved, and the use of hazardous reagents and environmental polluting reagents is avoided.

公开(公告)号：US20200181079A1

公开(公告)日：2020-06-11

申请号：US16608910

申请日：2018-05-31

Applicant: Daewoong Pharmaceutical Co., Ltd.

Inventor： Jeong-Taek Shin ,  Jeong-Hyun Son ,  Deok Ki Eom ,  Chun Ho Lee

IPC: C07D207/36

Abstract: The present invention relates to a method for preparing intermediates of 4-methoxypyrrole derivatives. The preparation method according to the present invention has advantages that a high-temperature reaction is not required as a whole, inexpensive and non-explosive reagents are used instead of (trimethylsilyl)diazomethane, and further an intermediate of 4-methoxy pyrrole derivatives can be prepared as a whole at a high yield.