公开(公告)号：US20140343052A1

公开(公告)日：2014-11-20

申请号：US14291860

申请日：2014-05-30

申请人： Daiichi Sankyo Company, Limited

发明人： Shigeo YAMANOI ,  Katsuji KAGECHIKA ,  Tsuyoshi SONEDA ,  Yuichi OCHIAI ,  Hidenori NAMIKI ,  Fuminao DOI ,  Madoka HOSHINO ,  Shoko YOSHIDA

IPC分类号： C07D405/10 ,  C07D413/14 ,  C07D405/14

CPC分类号： C07D405/10 ,  C07D405/14 ,  C07D413/14

摘要： The present invention relates to a compound or a pharmacologically acceptable salt thereof having an excellent glucose lowering effect.A compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof: wherein R1 represents a C1-C3 alkyl group, each substituent R2 may be the same or different and may each represent a C1-C3 alkyl group, R3 represents an optionally substituted pyridyl group or the like, R4 and R5, which are the same or different, each represent a C1-C3 alkyl group, R6 and R7, which are the same or different, each represent a C1-C3 alkyl group, and n represents 0 to 3.

摘要翻译： 本发明涉及具有优异葡萄糖降低作用的化合物或其药理学上可接受的盐。 由以下通式（I）表示的化合物或其药学上可接受的盐：其中R1表示C1-C3烷基，各取代基R2可以相同或不同，可各自表示C1-C3烷基，R3表示 任选取代的吡啶基等，R 4和R 5相同或不同，各自表示C1-C3烷基，R6和R7相同或不同，分别表示C1-C3烷基，和 n表示0〜3。

公开(公告)号：US20160081993A1

公开(公告)日：2016-03-24

申请号：US14956116

申请日：2015-12-01

申请人： DAIICHI SANKYO COMPANY, LIMITED

发明人： Shigeo YAMANOI ,  Hidenori NAMIKI ,  Yuichi OCHIAI ,  Madoka HOSHINO ,  Koji MATSUMOTO

IPC分类号： A61K31/4439 ,  A61K31/421

CPC分类号： C07D403/12 ,  A61K31/421 ,  A61K31/4439 ,  C07D249/06 ,  C07D257/04 ,  C07D263/32 ,  C07D271/06 ,  C07D277/20 ,  C07D277/30 ,  C07D401/12 ,  C07D401/14 ,  C07D413/12 ,  C07D417/12

摘要： Compounds are provided having an excellent hypoglycemic effect and β cell- or pancreas-protecting effects, or pharmaceutically acceptable salts thereof, and a pharmaceutical composition having an excellent therapeutic effect and/or prophylactic effect on type 1 diabetes, type 2 diabetes, and the like, which cause hyperglycemia due to abnormal glucose metabolism. A compound represented by general formula (I), or a pharmaceutically acceptable salt thereof, is disclosed.

公开(公告)号：US20220185815A1

公开(公告)日：2022-06-16

申请号：US17436500

申请日：2020-03-05

申请人： DAIICHI SANKYO COMPANY, LIMITED

发明人： Hidenori NAMIKI ,  Masanori SAITOU ,  Satoshi MATSUI ,  Yoshihiro SHIBATA ,  Yoshito KAWAMOTO ,  Rie ICHIKAWA ,  Yohei YOSHIHAMA ,  Akiko OTSUKA

IPC分类号： C07D487/04

摘要： The present invention provides a low molecular compound that inhibits phosphatidylserine synthase 1 or a pharmaceutically acceptable salt thereof, a pharmaceutical containing thereof, and a therapeutic agent for cancer having a suppressed function of phosphatidylserine synthase 2. The compound represented by formula (1) or a pharmaceutically acceptable salt thereof, wherein R1, ring Q1, ring Q2, and W are as defined in the specification.

公开(公告)号：US20160090375A1

公开(公告)日：2016-03-31

申请号：US14956240

申请日：2015-12-01

申请人： DAIICHI SANKYO COMPANY, LIMITED

发明人： Shigeo YAMANOI ,  Hidenori NAMIKI ,  Yuichi OCHIAI ,  Madoka HOSHINO ,  Koji MATSUMOTO

IPC分类号： C07D403/12 ,  C07D249/06 ,  C07D401/14 ,  C07D401/12

CPC分类号： C07D403/12 ,  A61K31/421 ,  A61K31/4439 ,  C07D249/06 ,  C07D257/04 ,  C07D263/32 ,  C07D271/06 ,  C07D277/20 ,  C07D277/30 ,  C07D401/12 ,  C07D401/14 ,  C07D413/12 ,  C07D417/12

摘要： Compounds are provided having an excellent hypoglycemic effect and β cell- or pancreas-protecting effects, or pharmaceutically acceptable salts thereof, and a pharmaceutical composition having an excellent therapeutic effect and/or prophylactic effect on type 1 diabetes, type 2 diabetes, and the like, which cause hyperglycemia due to abnormal glucose metabolism. A compound represented by general formula (I), or a pharmaceutically acceptable salt thereof, is disclosed.

摘要翻译： 提供具有优异的降血糖作用的化合物和 细胞或胰腺保护作用，或其药学上可接受的盐，以及由于葡萄糖代谢异常引起高血糖的1型糖尿病，2型糖尿病等具有优异的治疗效果和/或预防效果的药物组合物。 公开了由通式（I）表示的化合物或其药学上可接受的盐。