公开(公告)号：US20140343052A1

公开(公告)日：2014-11-20

申请号：US14291860

申请日：2014-05-30

申请人： Daiichi Sankyo Company, Limited

发明人： Shigeo YAMANOI ,  Katsuji KAGECHIKA ,  Tsuyoshi SONEDA ,  Yuichi OCHIAI ,  Hidenori NAMIKI ,  Fuminao DOI ,  Madoka HOSHINO ,  Shoko YOSHIDA

IPC分类号： C07D405/10 ,  C07D413/14 ,  C07D405/14

CPC分类号： C07D405/10 ,  C07D405/14 ,  C07D413/14

摘要： The present invention relates to a compound or a pharmacologically acceptable salt thereof having an excellent glucose lowering effect.A compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof: wherein R1 represents a C1-C3 alkyl group, each substituent R2 may be the same or different and may each represent a C1-C3 alkyl group, R3 represents an optionally substituted pyridyl group or the like, R4 and R5, which are the same or different, each represent a C1-C3 alkyl group, R6 and R7, which are the same or different, each represent a C1-C3 alkyl group, and n represents 0 to 3.

摘要翻译： 本发明涉及具有优异葡萄糖降低作用的化合物或其药理学上可接受的盐。 由以下通式（I）表示的化合物或其药学上可接受的盐：其中R1表示C1-C3烷基，各取代基R2可以相同或不同，可各自表示C1-C3烷基，R3表示 任选取代的吡啶基等，R 4和R 5相同或不同，各自表示C1-C3烷基，R6和R7相同或不同，分别表示C1-C3烷基，和 n表示0〜3。

公开(公告)号：US20230058950A1

公开(公告)日：2023-02-23

申请号：US17425520

申请日：2020-01-23

申请人： DAIICHI SANKYO COMPANY, LIMITED

发明人： Junya KAWAI ,  Osamu IWAMOTO ,  Yuma UMEZAKI ,  Katsuyoshi NAKAJIMA ,  Hiroyuki TSURUOKA ,  Keiji SAITO ,  Nobuya KURIKAWA ,  Natsumi NISHIHAMA ,  Shinji TANAKA ,  Momoko OGITANI ,  Tomohiro HONDA ,  Wataru SAITOH ,  Tsuyoshi SONEDA ,  Nobuyuki OHKAWA

IPC分类号： C07D513/18 ,  C07D513/04

摘要： An object of the present invention is to provide a compound that has a specific chemical structure having an activation effect on SIRT6 and is useful as an active component for preventing and treating inflammatory diseases, and the present invention relates to a compound represented by Formula (1) or a pharmaceutically acceptable salt thereof, where each symbol in Formula (1) has the same definition as that described in the specification.