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公开(公告)号:US5891902A
公开(公告)日:1999-04-06
申请号:US676177
申请日:1996-07-15
申请人: Daisuke Machii , Haruki Takai , Nobuo Kosaka , Hisakatsu Seo , Tomomi Sugiyama , Joji Nakamura , Hiroyuki Ishida , Katsushige Gomi , Soichiro Sato , Masako Uchii , Koji Suzuki
发明人: Daisuke Machii , Haruki Takai , Nobuo Kosaka , Hisakatsu Seo , Tomomi Sugiyama , Joji Nakamura , Hiroyuki Ishida , Katsushige Gomi , Soichiro Sato , Masako Uchii , Koji Suzuki
IPC分类号: C07D209/30 , C07D209/42 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D521/00 , A61K31/40 , C07D209/12 , C07D209/14
CPC分类号: C07D231/12 , C07D209/30 , C07D209/42 , C07D233/56 , C07D249/08 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要: The present invention relates to indole derivatives represented by formula (I): ##STR1## wherein R.sup.1 and R.sup.2 independently represent hydrogen, lower alkyl, hydroxy, lower alkoxy, halogen, --O--(CH.sub.2).sub.n --OR.sup.5, or ##STR2## R.sup.3 represents hydrogen, lower alkyl, or ##STR3## R.sup.4 represents hydroxy, lower alkoxy, substituted or unsubstituted aryloxy, or --NR.sup.10 R.sup.11, and X represents CO or SO.sub.2, with the proviso that when R.sup.3 is hydrogen or lower alkyl, and X is CO, R.sup.4 is --NR.sup.10 R.sup.11, or pharmaceutically acceptable salts thereof.
摘要翻译: 本发明涉及由式(I)表示的吲哚衍生物:其中R1和R2独立地表示氢,低级烷基,羟基,低级烷氧基,卤素,-O-(CH2)n-OR5或 R 3表示氢,低级烷基或R 4表示羟基,低级烷氧基,取代或未取代的芳氧基或-NR 10 R 11,X表示CO或SO 2,条件是当R 3为氢或低级烷基时,X 是CO,R 4是-NR 10 R 11,或其药学上可接受的盐。