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![1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl compounds and their medical use](/abs-image/US/2013/02/12/US08372832B2/abs.jpg.150x150.jpg)
1.发明授权1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl compounds and their medical use 有权1,4-二氮杂双环[3.2.2]壬基恶二唑基化合物及其医疗用途公开(公告)号：US08372832B2
公开(公告)日：2013-02-12
申请号：US13420071
申请日：2012-03-14
申请人： Dan Peters , Gunnar M. Olsen , Elsebet Østergaard Nielsen , Daniel B. Timmermann , Steven Charles Loechel , Jens Damsgaard Mikkelsen , Henrik Björk Hansen , John Paul Redrobe , Jeppe Kejser Christensen , Tino Dyhring
发明人： Dan Peters , Gunnar M. Olsen , Elsebet Østergaard Nielsen , Daniel B. Timmermann , Steven Charles Loechel , Jens Damsgaard Mikkelsen , Henrik Björk Hansen , John Paul Redrobe , Jeppe Kejser Christensen , Tino Dyhring
IPC分类号： A61P25/00 , A61K31/551 , C07D471/08
CPC分类号： C07D471/08
摘要： This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters.Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
摘要翻译： 本发明涉及新的1,4-二氮杂 - 双环[3.2.2]壬基恶二唑基衍生物及其在制备药物组合物中的用途。 发现本发明的化合物是烟碱乙酰胆碱受体的胆碱能配体和单胺受体和转运蛋白的调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。
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![1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL COMPOUNDS AND THEIR MEDICAL USE](/abs-image/US/2012/07/05/US20120172353A1/abs.jpg.150x150.jpg)
2.发明申请1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL COMPOUNDS AND THEIR MEDICAL USE 有权1,4-二氮杂双环[3.2.2]壬二酰氧基化合物及其医药用途公开(公告)号：US20120172353A1
公开(公告)日：2012-07-05
申请号：US13420071
申请日：2012-03-14
申请人： Dan PETERS , Gunnar M. Olsen , Elsebet Østergaard Nielsen , Daniel B. Timmermann , Steven Charles Loechel , Jens Damsgaard Mikkelsen , Henrik Björk Hansen , John Paul Redrobe , Jeppe Kejser Christensen , Tino Dyhring
发明人： Dan PETERS , Gunnar M. Olsen , Elsebet Østergaard Nielsen , Daniel B. Timmermann , Steven Charles Loechel , Jens Damsgaard Mikkelsen , Henrik Björk Hansen , John Paul Redrobe , Jeppe Kejser Christensen , Tino Dyhring
IPC分类号： A61K31/551 , A61P25/28 , A61P25/00 , A61P25/18 , A61P25/24 , A61P25/22 , A61P25/08 , A61P29/00 , A61P25/06 , A61P9/06 , A61P21/02 , A61P15/06 , A61P15/10 , A61P11/06 , A61P1/12 , A61P1/00 , A61P17/10 , A61P25/36 , A61P25/34 , A61P25/32 , C07D471/08
CPC分类号： C07D471/08
摘要： This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters.Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
摘要翻译： 本发明涉及新的1,4-二氮杂 - 双环[3.2.2]壬基恶二唑基衍生物及其在制备药物组合物中的用途。 发现本发明的化合物是烟碱乙酰胆碱受体的胆碱能配体和单胺受体和转运蛋白的调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。
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![NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES AND THEIR MEDICAL USE](/abs-image/US/2010/08/26/US20100216780A1/abs.jpg.150x150.jpg)
3.发明申请NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES AND THEIR MEDICAL USE 有权新的1,4-二氮杂双环[3.2.2]壬基氧杂环丁烷衍生物及其医疗用途公开(公告)号：US20100216780A1
公开(公告)日：2010-08-26
申请号：US12297333
申请日：2007-05-29
申请人： Dan Peters , Gunnar M. Olsen , Elsebet Østergaard Nielsen , Daniel B. Timmermann , Steven Charles Loechel , Jens Damsgaard Mikkelsen , Henrik Björk Hansen , John Paul Redrobe , Jeppe Kejser Christensen , Timo Dyhring
发明人： Dan Peters , Gunnar M. Olsen , Elsebet Østergaard Nielsen , Daniel B. Timmermann , Steven Charles Loechel , Jens Damsgaard Mikkelsen , Henrik Björk Hansen , John Paul Redrobe , Jeppe Kejser Christensen , Timo Dyhring
IPC分类号： A61K31/551 , C07D471/08 , A61P25/00 , A61P25/28 , A61P25/24 , A61P25/18 , A61P25/22 , A61P29/00 , A61P17/10 , A61P11/06 , A61P1/00
CPC分类号： C07D471/08
摘要： This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters.Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
摘要翻译： 本发明涉及新的1,4-二氮杂 - 双环[3.2.2]壬基恶二唑基衍生物及其在制备药物组合物中的用途。 发现本发明的化合物是烟碱乙酰胆碱受体的胆碱能配体和单胺受体和转运蛋白的调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。
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![1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl compounds and their medical use](/abs-image/US/2012/04/17/US08158619B2/abs.jpg.150x150.jpg)
4.发明授权1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl compounds and their medical use 有权1,4-二氮杂双环[3.2.2]壬基恶二唑基化合物及其医疗用途公开(公告)号：US08158619B2
公开(公告)日：2012-04-17
申请号：US12297333
申请日：2007-05-29
申请人： Dan Peters , Gunnar M. Olsen , Elsebet ØStergaard Nielsen , Daniel B. Timmermann , Steven Charles Loechel , Jen Damsgaard Mikkelsen , Henrik Björk Hansen , John Paul Redrobe , Jeppe Kejser Christensen , Tino Dyhring
发明人： Dan Peters , Gunnar M. Olsen , Elsebet ØStergaard Nielsen , Daniel B. Timmermann , Steven Charles Loechel , Jen Damsgaard Mikkelsen , Henrik Björk Hansen , John Paul Redrobe , Jeppe Kejser Christensen , Tino Dyhring
IPC分类号： A61P25/00 , A61K31/551 , C07D471/08
CPC分类号： C07D471/08
摘要： This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters.Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
摘要翻译： 本发明涉及新的1,4-二氮杂 - 双环[3.2.2]壬基恶二唑基衍生物及其在制备药物组合物中的用途。 发现本发明的化合物是烟碱乙酰胆碱受体的胆碱能配体和单胺受体和转运蛋白的调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。
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5.发明申请公开(公告)号：US20120202796A1
公开(公告)日：2012-08-09
申请号：US13061853
申请日：2009-09-02
IPC分类号： A61K31/439 , A61K31/5513 , A61P5/50 , A61P3/06 , A61P3/08 , C07D451/02 , A61P3/04
CPC分类号： A61K31/46 , A61K31/5513 , A61K2300/00
摘要： This invention relates to a method for combating adverse effects arising from antipsychotic treatment. The invention furthermore relates to novel pharmaceutical compositions comprising a therapeutically effective combination of a compound of formula I and an antipsychotic drug.
摘要翻译： 本发明涉及抗精神病药物治疗引起的不良反应的方法。 本发明还涉及包含式I化合物和抗精神病药物的治疗有效组合的新型药物组合物。
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6.发明授权公开(公告)号：US09457018B2
公开(公告)日：2016-10-04
申请号：US13061853
申请日：2009-09-02
IPC分类号： A61K31/4418 , C07D211/22 , A61K31/46 , A61K31/5513
CPC分类号： A61K31/46 , A61K31/5513 , A61K2300/00
摘要： This invention relates to a method for combating adverse effects arising from antipsychotic treatment. The invention furthermore relates to novel pharmaceutical compositions comprising a therapeutically effective combination of a compound of formula I and an antipsychotic drug.
摘要翻译： 本发明涉及抗精神病药物治疗引起的不良反应的方法。 本发明还涉及包含式I化合物和抗精神病药物的治疗有效组合的新型药物组合物。
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