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    Heteroaryl-diazabicycloalkanes
    1.
    发明授权
    Heteroaryl-diazabicycloalkanes 失效
    杂芳基 - 二氮杂双环烷烃

    公开(公告)号：US06815438B2

    公开(公告)日：2004-11-09

    申请号：US10130099

    申请日：2002-05-14

    申请人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Ostergaard Nielsen ,  Philip K. Ahring ,  Simon Feldbaek Nielsen ,  Tino Dyhring Jorgensen

    发明人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Ostergaard Nielsen ,  Philip K. Ahring ,  Simon Feldbaek Nielsen ,  Tino Dyhring Jorgensen

    IPC分类号： A61K3133

    CPC分类号： C07D471/08 ,  C07D487/04 ,  C07D487/08

    摘要： The present invention relates to novel heteroaryl-diazabicycloalkanes which are found to be cholinergic ligands at the nicotinic Acetyl Choline Receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neurodegeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及在烟碱乙酰胆碱受体中被发现是胆碱能配体的新型杂芳基 - 二氮杂双环烷烃。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS）的胆碱能系统有关的疾病或病症，与平滑肌收缩相关的疾病或病症，内分泌疾病或 与神经变性相关的疾病，疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

    3-Substituted quinuclidines and their use
    2.
    发明申请
    3-Substituted quinuclidines and their use 审中-公开
    3-取代的奎宁和它们的用途

    公开(公告)号：US20080132704A1

    公开(公告)日：2008-06-05

    申请号：US12004022

    申请日：2007-12-20

    申请人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Ostergaard Nielsen ,  Philip K. Ahring ,  Tino Dyhring Jorgensen

    发明人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Ostergaard Nielsen ,  Philip K. Ahring ,  Tino Dyhring Jorgensen

    IPC分类号： C07D453/02

    CPC分类号： C07D453/02

    摘要： This invention relates to novel 3-substituted quinuclidine derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters.Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及新的3-取代的奎宁环衍生物，其被发现是烟碱乙酰胆碱受体的胆碱能配体和单胺受体和转运蛋白的调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

    2,5-diazabicyclo[2.2.1]heptane derivatives
    5.
    发明授权
    2,5-diazabicyclo[2.2.1]heptane derivatives 失效
    2,5-二氮杂双环[2.2.1]庚烷衍生物

    公开(公告)号：US07329754B2

    公开(公告)日：2008-02-12

    申请号：US10250765

    申请日：2002-02-28

    申请人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Ostergaard Nielsen ,  Philip K. Ahring ,  Tino Dyhring Jorgensen

    发明人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Ostergaard Nielsen ,  Philip K. Ahring ,  Tino Dyhring Jorgensen

    IPC分类号： C07D215/38 ,  C07D265/30

    CPC分类号： C07D487/08 ,  A61K31/4995

    摘要： The present invention relates to novel 2,5-diazabicyclo[2.2.1]heptane derivatives, which are found to be potent modulators of the monoamine receptors and transporters.Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及新的2,5-二氮杂双环[2.2.1]庚烷衍生物，其被发现是单胺受体和转运蛋白的有效调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

    Novel azacyclic ethynyl derivatives
    6.
    发明申请
    Novel azacyclic ethynyl derivatives 失效
    新型氮杂环乙炔衍生物

    公开(公告)号：US20080188519A1

    公开(公告)日：2008-08-07

    申请号：US12076929

    申请日：2008-03-25

    申请人： Dan Peters ,  Gurmar M. Olsen ,  Elsebet Ostergaard Nielsen ,  Tino Dyhring Jorgensen ,  Philip K. Ahring

    发明人： Dan Peters ,  Gurmar M. Olsen ,  Elsebet Ostergaard Nielsen ,  Tino Dyhring Jorgensen ,  Philip K. Ahring

    IPC分类号： C07D453/02 ,  A61K31/439 ,  A61P3/00 ,  A61P25/00

    CPC分类号： C07D451/02 ,  C07D211/70 ,  C07D453/02

    摘要： Azacyclic ethynyl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 在烟碱乙酰胆碱受体和单胺受体和转运蛋白的调节剂中发现其是胆碱能配体的偶氮环乙炔衍生物。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

    Dimeric Azacyclic Compounds and Their Use
    7.
    发明申请
    Dimeric Azacyclic Compounds and Their Use 失效
    二甲基偶氮化合物及其用途

    公开(公告)号：US20080242668A1

    公开(公告)日：2008-10-02

    申请号：US10586838

    申请日：2005-02-01

    申请人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Ostergaard Nielsen ,  Tino Dyhring Jorgensen ,  Daniel B. Timmermann

    发明人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Ostergaard Nielsen ,  Tino Dyhring Jorgensen ,  Daniel B. Timmermann

    IPC分类号： A61K31/498 ,  C07D221/02 ,  A61K31/4375 ,  A61P9/00 ,  A61P29/00 ,  A61P25/00 ,  C07D403/02

    摘要： This invention relates to azacyclic derivatives according of formula (I) and their use as pharmaceuticals. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or. disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the′ termination of abuse of chemical substances. Formula (I) Aza-X′-A′-Y′-L-Y-A″-X″-Aza Aza:Azabicyclic group A′,A″:Aromatic monocyclic and/or polycyclic, carbocyclic and/or heterocyclic group Y′,Y″: Linker or absent (covalent bond) L: Monocyclic or polycyclic, carbocyclic or heterocyclic group or is absent X′,X″: Linker or absent (covalent bond)

    摘要翻译： 本发明涉及式（I）的氮杂环十二烷基衍生物及其作为药物的用途。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或疾病，疾病或。 与“终止化学物质的滥用”引起的与炎症，疼痛和戒断症状有关的神经变性，疾病或病症相关的疾病。 式（I）Aza-X'-A'-Y'-LY-A“-X” - 氮杂氮杂：氮杂双环基A'，A“：芳族单环和/或多环，碳环和/或杂环基 Y'，Y“：连接体或不存在（共价键）L：单环或多环，碳环或杂环基团或不存在X'，X”：连接基或不存在（共价键）

    Diazabicyclic Aryl Derivatives as Cholinergic Receptor Modulators
    8.
    发明申请
    Diazabicyclic Aryl Derivatives as Cholinergic Receptor Modulators 失效
    二氮杂双环衍生物作为胆碱能受体调节剂

    公开(公告)号：US20080227773A1

    公开(公告)日：2008-09-18

    申请号：US10586836

    申请日：2005-02-01

    申请人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Ostergaard Nielsen ,  Tino Dyhring Jorgensen ,  Daniel B Timmermann

    发明人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Ostergaard Nielsen ,  Tino Dyhring Jorgensen ,  Daniel B Timmermann

    IPC分类号： A61K31/551 ,  C07D243/00 ,  A61P25/02 ,  A61P25/28 ,  A61P25/34 ,  A61P37/02

    CPC分类号： C07D471/08

    摘要： This invention relates to novel diazabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemicals substances.

    摘要翻译： 本发明涉及新的二氮杂双环芳基衍生物，其在烟碱乙酰胆碱受体和单胺受体和转运蛋白的调节剂中被发现是胆碱能配体。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

    Novel Diazabicyclic Aryl Derivatives And Their Medical Use
    9.
    发明申请
    Novel Diazabicyclic Aryl Derivatives And Their Medical Use 审中-公开
    新型二氮杂双环芳烃衍生物及其医疗用途

    公开(公告)号：US20080153806A1

    公开(公告)日：2008-06-26

    申请号：US11665387

    申请日：2005-10-18

    申请人： Dan Peters ,  Daniel B. Timmermann ,  Gunnar M. Olsen ,  Elsebet Ostergaard Nielsen ,  Tino Dyhring Jorgensen

    发明人： Dan Peters ,  Daniel B. Timmermann ,  Gunnar M. Olsen ,  Elsebet Ostergaard Nielsen ,  Tino Dyhring Jorgensen

    IPC分类号： A61K31/55 ,  C07D223/14 ,  A61P25/00 ,  A61P3/00 ,  A61P21/00 ,  A61P5/00 ,  A61P29/00

    CPC分类号： C07D487/08

    摘要： This invention relates to novel diazabicyclic aryl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及新的二氮杂双环芳基衍生物，其被发现是烟碱乙酰胆碱受体的胆碱能配体和单胺受体和转运蛋白的调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

    8-Azabicyclo[3.2.1]oct-2-ene and -octane derivatives technical field
    10.
    发明授权
    8-Azabicyclo[3.2.1]oct-2-ene and -octane derivatives technical field 失效
    8-氮杂双环[3.2.1]辛-2-烯和 - 辛烷衍生物技术领域

    公开(公告)号：US07045522B2

    公开(公告)日：2006-05-16

    申请号：US10726680

    申请日：2003-12-04

    申请人： Dan Peters ,  Gunnar M. Olsen ,  Simon Feldbaek Nielsen ,  Elsebet Ostergaard Nielsen

    发明人： Dan Peters ,  Gunnar M. Olsen ,  Simon Feldbaek Nielsen ,  Elsebet Ostergaard Nielsen

    IPC分类号： A61K31/46 ,  A61K31/4709 ,  C07D451/02

    CPC分类号： A61K31/46 ,  C07D451/02

    摘要： The present invention relates to novel 8-azabicyclo[3.2.1]oct-2-ene and -octane derivatives which are found to be cholinergic ligands at the nicotinic Acetyl Choline Receptors.Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neurodegeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及在烟碱乙酰胆碱受体中被发现是胆碱能配体的新的8-氮杂双环[3.2.1]辛-2-烯和 - 辛烷衍生物。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS）的胆碱能系统有关的疾病或病症，与平滑肌收缩相关的疾病或病症，内分泌疾病或 与神经变性相关的疾病，疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。