公开(公告)号：US20240294516A1

公开(公告)日：2024-09-05

申请号：US18643018

申请日：2024-04-23

申请人： NeuroPn Therapeutics, Inc.

发明人： Ish Khanna ,  Sivaram Pillarisetti

IPC分类号： C07D413/10 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  A61P25/02 ,  A61P25/16 ,  C07D211/70 ,  C07D401/12

CPC分类号： C07D413/10 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  A61P25/02 ,  A61P25/16 ,  C07D211/70 ,  C07D401/12

摘要： Described herein are novel piperidine urea derived compounds and their pharmaceutical compositions for the treatment of conditions and diseases mediated by soluble epoxide hydrolase.

公开(公告)号：US20240254066A1

公开(公告)日：2024-08-01

申请号：US18560341

申请日：2022-05-12

申请人： GW Research Limited

发明人： Alan James SILCOCK ,  Karen Ka-Yen TSE ,  Paul Stuart HINCHLIFFE ,  Andrew SHARPE ,  Iain David SIMPSON ,  Joanne PEACH ,  Stefano LEVANTO ,  Antoine MILLET ,  Inderjit Singh MANN

IPC分类号： C07C43/295 ,  A61K31/05 ,  A61K31/055 ,  A61K31/075 ,  A61K31/085 ,  A61K31/137 ,  A61K31/277 ,  A61K31/351 ,  A61K31/36 ,  A61K31/415 ,  A61K31/42 ,  A61K31/426 ,  A61K31/4418 ,  A61K31/505 ,  A61P25/08 ,  C07C29/143 ,  C07C35/18 ,  C07C37/48 ,  C07C37/56 ,  C07C39/23 ,  C07C39/42 ,  C07C41/03 ,  C07C41/26 ,  C07C41/30 ,  C07C43/23 ,  C07C67/08 ,  C07C67/287 ,  C07C69/94 ,  C07C213/08 ,  C07C215/50 ,  C07C253/30 ,  C07C255/36 ,  C07C303/30 ,  C07C309/87 ,  C07D211/70 ,  C07D213/30 ,  C07D213/61 ,  C07D213/64 ,  C07D213/65 ,  C07D231/12 ,  C07D239/34 ,  C07D261/08 ,  C07D277/24 ,  C07D309/22 ,  C07D317/54

CPC分类号： C07C43/295 ,  A61K31/05 ,  A61K31/055 ,  A61K31/075 ,  A61K31/085 ,  A61K31/137 ,  A61K31/277 ,  A61K31/351 ,  A61K31/36 ,  A61K31/415 ,  A61K31/42 ,  A61K31/426 ,  A61K31/4418 ,  A61K31/505 ,  A61P25/08 ,  C07C29/143 ,  C07C35/18 ,  C07C37/48 ,  C07C37/56 ,  C07C39/23 ,  C07C39/42 ,  C07C41/03 ,  C07C41/26 ,  C07C41/30 ,  C07C43/23 ,  C07C67/08 ,  C07C67/287 ,  C07C69/94 ,  C07C213/08 ,  C07C215/50 ,  C07C253/30 ,  C07C255/36 ,  C07C303/30 ,  C07C309/87 ,  C07D211/70 ,  C07D213/30 ,  C07D213/61 ,  C07D213/64 ,  C07D213/65 ,  C07D231/12 ,  C07D239/34 ,  C07D261/08 ,  C07D277/24 ,  C07D309/22 ,  C07D317/54 ,  C07C2601/02 ,  C07C2601/10 ,  C07C2601/16

摘要： The present invention relates to a group of resorcinol derivatives as a pharmaceutically active compounds and methods of preparation thereof. Resorcinol derivatives have been used to treat various diseases and disorders. While such treatments hold promise, there remains a need in the art for more effective treatments and this has been brought about by way of the resorcinol derivative of the invention.

公开(公告)号：US11884654B2

公开(公告)日：2024-01-30

申请号：US17470464

申请日：2021-09-09

申请人： CHEMOCENTRYX, INC.

发明人： Trevor T. Charvat ,  Junfa Fan ,  Christopher W. Lange ,  Manmohan Reddy Leleti ,  Yandong Li ,  Venkat Reddy Mali ,  Jeffrey P. McMahon ,  Jay Powers ,  Sreenivas Punna ,  Ju Yang

IPC分类号： A01N43/00 ,  A61K31/00 ,  C07D413/06 ,  C07D401/04 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D417/04 ,  C07D211/56 ,  C07D295/135 ,  C07D211/62 ,  C07D211/26 ,  C07D211/70 ,  C07D241/04 ,  C07D207/16 ,  C07D211/34 ,  A61K31/451 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/495 ,  A61K31/496 ,  A61K31/5377

CPC分类号： C07D413/06 ,  A61K31/451 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/495 ,  A61K31/496 ,  A61K31/5377 ,  C07D207/16 ,  C07D211/26 ,  C07D211/34 ,  C07D211/56 ,  C07D211/62 ,  C07D211/70 ,  C07D241/04 ,  C07D295/135 ,  C07D401/04 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D417/04

摘要： Aniline compounds are provided which bind to CCR(4) and are useful for the treatment of diseases such as allergic diseases, autoimmune diseases, graft rejection and cancer.

公开(公告)号：US20190077790A1

公开(公告)日：2019-03-14

申请号：US16080323

申请日：2016-04-03

申请人： Boehringer Ingelheim International GmbH

发明人： Frank HIMMELSBACH ,  Andreas BLUM ,  Stefan PETERS

IPC分类号： C07D403/04 ,  C07D401/04 ,  C07D295/116 ,  C07D295/096 ,  C07D205/04 ,  C07D471/04 ,  C07D211/34 ,  C07D211/26 ,  C07D211/70 ,  C07D417/04 ,  C07D413/04 ,  C07D451/02 ,  C07D471/20

CPC分类号： C07D403/04 ,  A61P1/16 ,  C07D205/04 ,  C07D211/14 ,  C07D211/18 ,  C07D211/22 ,  C07D211/26 ,  C07D211/28 ,  C07D211/34 ,  C07D211/52 ,  C07D211/58 ,  C07D211/62 ,  C07D211/64 ,  C07D211/70 ,  C07D211/96 ,  C07D213/72 ,  C07D213/82 ,  C07D213/85 ,  C07D237/20 ,  C07D239/42 ,  C07D239/47 ,  C07D241/04 ,  C07D241/08 ,  C07D241/20 ,  C07D251/42 ,  C07D277/38 ,  C07D295/096 ,  C07D295/116 ,  C07D295/155 ,  C07D309/14 ,  C07D401/04 ,  C07D405/04 ,  C07D413/04 ,  C07D417/04 ,  C07D451/02 ,  C07D471/04 ,  C07D471/20

摘要： The invention relates to new benzonitrile derivatives of the formula (I) wherein R1 to R3 and A are as defined in the description and Claims, to their medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.

公开(公告)号：US20190038578A1

公开(公告)日：2019-02-07

申请号：US16153706

申请日：2018-10-06

申请人： National Institute of Biological Sciences, Beijing

发明人： Zhiyuan Zhang ,  Xiaodong Wang ,  Yaning Su ,  Hanying Ruan ,  Yan Ren

IPC分类号： A61K31/165 ,  C07D417/04 ,  C07D263/22 ,  C07D207/12 ,  C07D205/04 ,  C07D263/04 ,  C07D205/08 ,  C07D261/02 ,  C07D207/06 ,  C07D231/02 ,  C07D241/04 ,  C07D207/08 ,  C07D231/08 ,  C07D233/38 ,  C07D207/20 ,  C07D211/16 ,  C07D207/24 ,  C07D405/04 ,  C07C233/01 ,  C07D265/30 ,  C07C235/38 ,  C07D231/04 ,  C07D211/70 ,  C07D207/333 ,  C07D207/27 ,  C07D203/18 ,  C07D409/04 ,  A61K31/167 ,  A61K31/10 ,  C07D211/82

CPC分类号： A61K31/165 ,  A61K31/10 ,  A61K31/167 ,  C07C233/01 ,  C07C235/38 ,  C07D203/18 ,  C07D205/04 ,  C07D205/08 ,  C07D207/06 ,  C07D207/08 ,  C07D207/12 ,  C07D207/20 ,  C07D207/24 ,  C07D207/27 ,  C07D207/333 ,  C07D211/16 ,  C07D211/70 ,  C07D211/82 ,  C07D231/02 ,  C07D231/04 ,  C07D231/08 ,  C07D233/38 ,  C07D241/04 ,  C07D261/02 ,  C07D263/04 ,  C07D263/22 ,  C07D265/30 ,  C07D405/04 ,  C07D409/04 ,  C07D417/04

摘要： The invention provides amides that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.

公开(公告)号：US20180298002A1

公开(公告)日：2018-10-18

申请号：US15768175

申请日：2016-10-14

申请人： THE UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

发明人： Nicole Alana Horenstein ,  Roger Lee Papke ,  Marta Quadri

IPC分类号： C07D471/10 ,  C07D211/58 ,  C07D211/70 ,  C07D295/037 ,  C07D295/073 ,  C07D295/096 ,  C07D295/155

CPC分类号： C07D471/10 ,  A61K31/42 ,  A61K31/452 ,  A61K31/495 ,  A61K31/499 ,  C07D211/58 ,  C07D211/70 ,  C07D295/037 ,  C07D295/073 ,  C07D295/096 ,  C07D295/155 ,  A61K2300/00

摘要： Derivatives of N,N-diethyl-N′-phenyl-piperazine, a silent agonist of the mammalian α7 nicotinic acetylcholine receptor, are provided. These silent agonists control the desensitization state of the receptor. Further provided are pharmaceutical compositions that allow the administration of the silent agonists of the disclosure to a subject animal or human in need of treatment for a pathological condition arising from such as inflammation. The novel silent agonists also may be co-administered to a patient simultaneously or consecutively with a type II positive allosteric modulator to modulate the activity of the receptor.

公开(公告)号：US20180162846A1

公开(公告)日：2018-06-14

申请号：US15674230

申请日：2017-08-10

申请人： CHEMOCENTRYX, INC.

发明人： Trevor T. CHARVAT ,  Junfa FAN ,  Christopher W. LANGE ,  Manmohan Reddy LELETI ,  Yandong LI ,  Venkat Reddy MALI ,  Jeffrey P. McMAHON ,  Jay POWERS ,  Sreenivas PUNNA ,  Ju YANG

IPC分类号： C07D413/06 ,  A61K31/5377 ,  C07D401/04 ,  A61K31/495 ,  A61K31/4545 ,  A61K31/454 ,  A61K31/451 ,  C07D211/34 ,  C07D207/16 ,  C07D241/04 ,  C07D211/70 ,  C07D211/26 ,  C07D211/62 ,  C07D295/135 ,  C07D211/56 ,  C07D417/04 ,  C07D405/06 ,  C07D403/06 ,  C07D401/06 ,  A61K31/496

CPC分类号： C07D413/06 ,  A61K31/451 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/495 ,  A61K31/496 ,  A61K31/5377 ,  C07D207/16 ,  C07D211/26 ,  C07D211/34 ,  C07D211/56 ,  C07D211/62 ,  C07D211/70 ,  C07D241/04 ,  C07D295/135 ,  C07D401/04 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D417/04

摘要： Aniline compounds are provided which bind to CCR(4) and are useful for the treatment of diseases such as allergic diseases, autoimmune diseases, graft rejection and cancer.

公开(公告)号：US20180155288A1

公开(公告)日：2018-06-07

申请号：US15888631

申请日：2018-02-05

申请人： CORAL SUNSCREEN PTY LTD

发明人： Mark York ,  John Ryan ,  Gregory Paul Savage ,  Adam Gerhard Meyer ,  Karen Jarvis

IPC分类号： C07D211/70 ,  C07D405/06 ,  C07D211/72 ,  C07D211/78 ,  C07D401/06 ,  C07D401/04 ,  C07D223/04 ,  C07D207/20 ,  A61Q17/04 ,  A61K8/49 ,  C07F7/21 ,  A61K8/58 ,  C09D5/32 ,  C09D7/63

CPC分类号： C07D211/70 ,  A61K8/4926 ,  A61K8/4946 ,  A61K8/585 ,  A61Q17/04 ,  C07D207/20 ,  C07D211/72 ,  C07D211/78 ,  C07D223/04 ,  C07D401/04 ,  C07D401/06 ,  C07D405/06 ,  C07F7/21 ,  C08K5/005 ,  C08K5/3432 ,  C08K5/3445 ,  C08K5/36 ,  C08K5/41 ,  C08K5/435 ,  C08K5/5442 ,  C09D5/32 ,  C09D7/63

摘要： There is provided a range of novel compounds which have been demonstrated to have useful electromagnetic radiation absorbing properties. These compounds will find use in a range of applications such as active components in sunscreen formulations, paints, plastics, fabrics, glass and UV protective coatings.

公开(公告)号：US20180105494A1

公开(公告)日：2018-04-19

申请号：US15841971

申请日：2017-12-14

申请人： Immunomet Therapeutics Inc.

发明人： Chang Hee MIN ,  Yong Eun KIM ,  Byung Kyu OH ,  Ji Sun LEE ,  Hye Jin HEO ,  Ju Hoon OH ,  Woong CHO

IPC分类号： C07D211/70 ,  C07D207/20 ,  C07D211/14 ,  C07D211/16

CPC分类号： C07D211/70 ,  C07D207/20 ,  C07D211/14 ,  C07D211/16

摘要： The present invention provides an N1-cyclic amine-N5-substituted biguanide derivative compound represented by Formula 1, a method of preparing the same and a pharmaceutical composition including the biguanide derivative or the pharmaceutically acceptable salt thereof as an active ingredient. The biguanide derivatives have an effect of inhibiting cancer cell proliferation, cancer metastasis and cancer recurrence by activation of AMPK, even when administered in a small dose compared with conventional drugs.

公开(公告)号：US20180086709A1

公开(公告)日：2018-03-29

申请号：US15718474

申请日：2017-09-28

申请人： Dong-A St Co., Ltd.

发明人： Sun-Ho Choi ,  Weon-Bin Im ,  Sung-Hak Choi ,  Chong-Hwan Cho ,  Ho-Sang Moon ,  Jung-Sang Park ,  Min-Jung Lee ,  Hyun-Jung Sung ,  Jun-Hwan Moon ,  Seung-Hyun Song ,  Hyung-Keun Lee ,  Ji-Hoon Choi ,  Cheon-Hyoung Park ,  Yoon-Jung Kim ,  Jin-Hyuk Kim

IPC分类号： C07D211/70 ,  C07D401/10 ,  C07D409/10 ,  C07D405/10 ,  C07D401/04

CPC分类号： C07D211/70 ,  C07D401/04 ,  C07D401/10 ,  C07D405/10 ,  C07D409/10

摘要： The present disclosure relates to a novel tetrahydropyridine derivative compound, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, methods for preparing the compounds, methods for inhibiting UDP-3-O—(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC), methods for treating Gram-negative bacterial infections, the use of the compounds for the preparation of therapeutic medicaments for treating Gram-negative bacterial infections, and pharmaceutical compositions for prevention or treatment of Gram-negative bacterial infections, which contain the compounds. The compounds represented by formula I, stereoisomers thereof or pharmaceutically acceptable salts thereof according to the present disclosure can exhibit excellent effects on the treatment bacterial infections.