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公开(公告)号：US10464897B2
公开(公告)日：2019-11-05
申请号：US15577845
申请日：2016-06-03
发明人： James Bradner , Michael Erb , Jun Qi
IPC分类号： C07D211/44 , C07D401/14 , C07D401/04 , C07D413/04 , C07D239/78 , C07D471/04 , C07D211/58 , C07D213/30 , A61P35/00
摘要： The present application relates to compounds comprising an ester, a thioester, or a hydrazide moiety and methods of synthesizing these compounds. The present application also relates to pharmaceutical compositions containing the compounds and methods of treating cell proliferative disorders mediated by the Hh signaling pathway, such as cancer, by administering the compounds and pharmaceutical compositions to subjects in need thereof.
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公开(公告)号：US20240092735A1
公开(公告)日：2024-03-21
申请号：US18503556
申请日：2023-11-07
发明人： James Bradner , Michael Erb , Jun Qi
IPC分类号： C07D211/44 , A61P35/00 , C07D211/58 , C07D213/30 , C07D239/78 , C07D401/04 , C07D401/14 , C07D413/04 , C07D471/04
CPC分类号： C07D211/44 , A61P35/00 , C07D211/58 , C07D213/30 , C07D239/78 , C07D401/04 , C07D401/14 , C07D413/04 , C07D471/04
摘要： The present application relates to compounds comprising an ester, a thioester, or a hydrazide moiety and methods of synthesizing these compounds. The present application also relates to pharmaceutical compositions containing the compounds and methods of treating cell proliferative disorders mediated by the Hedgehog (Hh) signaling pathway, such as cancer, by administering the compounds and pharmaceutical compositions to subjects in need thereof.
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公开(公告)号：US11845728B2
公开(公告)日：2023-12-19
申请号：US17158759
申请日：2021-01-26
发明人： James Bradner , Michael Erb , Jun Qi
IPC分类号： C07D211/44 , C07D401/14 , C07D401/04 , C07D413/04 , C07D239/78 , C07D471/04 , C07D211/58 , C07D213/30 , A61P35/00
CPC分类号： C07D211/44 , A61P35/00 , C07D211/58 , C07D213/30 , C07D239/78 , C07D401/04 , C07D401/14 , C07D413/04 , C07D471/04
摘要： The present application relates to compounds comprising an ester, a thioester, or a hydrazide moiety and methods of synthesizing these compounds. The present application also relates to pharmaceutical compositions containing the compounds and methods of treating cell proliferative disorders mediated by the Hedgehog (Hh) signaling pathway, such as cancer, by administering the compounds and pharmaceutical compositions to subjects in need thereof.
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公开(公告)号：US20210147359A1
公开(公告)日：2021-05-20
申请号：US17158759
申请日：2021-01-26
发明人： James Bradner , Michael Erb , Jun Qi
IPC分类号： C07D211/44 , C07D401/14 , C07D401/04 , C07D413/04 , C07D239/78 , C07D471/04 , C07D211/58 , C07D213/30 , A61P35/00
摘要： The present application relates to compounds comprising an ester, a thioester, or a hydrazide moiety and methods of synthesizing these compounds. The present application also relates to pharmaceutical compositions containing the compounds and methods of treating cell proliferative disorders mediated by the Hedgehog (Hh) signaling pathway, such as cancer, by administering the compounds and pharmaceutical compositions to subjects in need thereof.
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公开(公告)号：US10934256B2
公开(公告)日：2021-03-02
申请号：US16575733
申请日：2019-09-19
发明人： James Bradner , Michael Erb , Jun Qi
IPC分类号： C07D211/44 , C07D401/14 , C07D401/04 , C07D413/04 , C07D239/78 , C07D471/04 , C07D211/58 , C07D213/30 , A61P35/00
摘要： The present application relates to compounds comprising an ester, a thioester, or a hydrazide moiety and methods of synthesizing these compounds. The present application also relates to pharmaceutical compositions containing the compounds and methods of treating cell proliferative disorders mediated by the Hh signaling pathway, such as cancer, by administering the compounds and pharmaceutical compositions to subjects in need thereof.
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